Purpose Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy. Up
till now, the patient's prognosis remains poor which, among others, is due to the paucity of
reliable early diagnostic biomarkers. In the past, candidate diagnostic biomarkers and …

A 'Down Syndrome critical region'(DSCR) sufficient to induce the most constant phenotypes
of Down syndrome (DS) had been identified by studying partial (segmental) trisomy 21
(PT21) as an interval of 0.6–8.3 Mb within human chromosome 21 (Hsa21), although its …

We have developed GeneBase, a full parser of the National Center for Biotechnology
Information (NCBI) Gene database, which generates a fully structured local database with
an intuitive user-friendly graphic interface for personal computers. Features of all the …

The understanding of the genetic basis of the Parkinson's disease (PD) and the correlation
between genotype and phenotype has revolutionized our knowledge about the
pathogenetic mechanisms of neurodegeneration, opening up exciting new therapeutic and …

The ideal reference, or control, gene for the study of gene expression in a given organism
should be expressed at a medium‑high level for easy detection, should be expressed at a
constant/stable level throughout different cell types and within the same cell type undergoing …

Colorectal cancer (CRC) is the third most common cancer in the world. A significant survival
rate is achieved if it is detected at an early stage. A whole blood screening test, without any
attempt to isolate blood fractions, could be an important tool to improve early detection of …

Basic parameters commonly used to describe genomes including length, weight and relative
guanine-cytosine (GC) content are widely cited in absence of a primary source. By using
updated data and original software we determined these values to the best of our …

Metastatic melanoma is an aggressive skin cancer and is one of the global malignancies
with high mortality and morbidity. It is essential to identify and verify diagnostic biomarkers of
early metastatic melanoma. Previous studies have systematically assessed protein …

Down syndrome (DS) is due to the presence of an extra full or partial chromosome 21
(Hsa21). The identification of genes contributing to DS pathogenesis could be the key to any
rational therapy of the associated intellectual disability. We aim at generating quantitative …

The incidence of Acute Megakaryoblastic Leukemia (AMKL) is 500-fold higher in children
with Down Syndrome (DS) compared with non-DS children, but the relevance of trisomy 21
as a specific background of AMKL in DS is still an open issue. Several Authors have …