Reported values in the literature on the number of cells in the body differ by orders of
magnitude and are very seldom supported by any measurements or calculations. Here, we
integrate the most up-to-date information on the number of human and bacterial cells in the …

Some tissue types give rise to human cancers millions of times more often than other tissue
types. Although this has been recognized for more than a century, it has never been
explained. Here, we show that the lifetime risk of cancers of many different types is strongly …

The human microbiome has emerged as an area of utmost interest. The last two decades have
produced an avalanche of studies revealing the impact that the microbiota have on the physiology
and metabolism of multicellular organisms with implications for health and disease. One of the …

The field of single-cell genomics is advancing rapidly and is generating many new insights
into complex biological systems, ranging from the diversity of microbial ecosystems to the
genomics of human cancer. In this Review, we provide an overview of the current state of the …

Single-cell sequencing (SCS) has emerged as a powerful new set of technologies for
studying rare cells and delineating complex populations. Over the past 5 years, SCS
methods for DNA and RNA have had a broad impact on many diverse fields of biology …

Droplet-based bioprinting (DBB) offers greater advantages due to its simplicity and agility
with precise control on deposition of biologics including cells, growth factors, genes, drugs
and biomaterials, and has been a prominent technology in the bioprinting community. Due …

The human gastrointestinal tract is populated by a diverse, highly mutualistic microbial flora,
which is known as the microbiome. Disruptions to the microbiome have been shown to be
associated with severe pathologies of the host, including metabolic disease, cancer, and …

The human body generates 10–100 billion cells every day, and the same number of cells
die to maintain homeostasis in our body. Cells infected by bacteria or viruses also die. The
cell death that occurs under physiological conditions mainly proceeds by apoptosis, which is …

Single-cell sequencing (SCS) is a powerful new tool for investigating evolution and diversity
in cancer and understanding the role of rare cells in tumor progression. These methods
have begun to unravel key questions in cancer biology that have been difficult to address …

We applied a combinatorial indexing assay, sci-ATAC-seq, to profile genome-wide
chromatin accessibility in∼ 100,000 single cells from 13 adult mouse tissues. We identify 85
distinct patterns of chromatin accessibility, most of which can be assigned to cell types …