Harry T. Orr
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Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1
HT Orr, M Chung, S Banfi, TJ Kwiatkowski Jr, A Servadio, AL Beaudet, ...
Nature genetics 4 (3), 221-226, 1993
Trinucleotide repeat disorders
HT Orr, HY Zoghbi
Annu. Rev. Neurosci. 30 (1), 575-621, 2007
Glutamine repeats and neurodegeneration
HY Zoghbi, HT Orr
Annual review of neuroscience 23 (1), 217-247, 2000
Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14
GD Schellenberg, TD Bird, EM Wijsman, HT Orr, L Anderson, E Nemens, ...
Science 258 (5082), 668-671, 1992
Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice
IA Klement, PJ Skinner, MD Kaytor, H Yi, SM Hersch, HB Clark, ...
Cell 95 (1), 41-53, 1998
Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1
CJ Cummings, MA Mancini, B Antalffy, DB DeFranco, HT Orr, HY Zoghbi
Nature genetics 19 (2), 148-154, 1998
RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia
H Xia, Q Mao, SL Eliason, SQ Harper, IH Martins, HT Orr, HL Paulson, ...
Nature medicine 10 (8), 816-820, 2004
Identification of genes that modify ataxin-1-induced neurodegeneration
P Fernandez-Funez, ML Nino-Rosales, B De Gouyon, WC She, ...
Nature 408 (6808), 101-106, 2000
SCA1 transgenic mice: a model for neurodegeneration caused by an expanded CAG trinucleotide repeat
EN Burright, HB Clark, A Servadio, T Matilla, RM Feddersen, WS Yunis, ...
Cell 82 (6), 937-948, 1995
A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment.
DE Geraghty, BH Koller, HT Orr
Proceedings of the national academy of sciences 84 (24), 9145-9149, 1987
Major histocompatibility antigens: the human (HLA-A,-B,-C) and murine (H-2K, H-2D) class I molecules
HL Ploegh, HT Orr, JL Strominger
Cell 24 (2), 287-299, 1981
Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures
PJ Skinner, BT Koshy, CJ Cummings, IA Klement, K Helin, A Servadio, ...
Nature 389 (6654), 971-974, 1997
Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice
CJ Cummings, Y Sun, P Opal, B Antalffy, R Mestril, HT Orr, WH Dillmann, ...
Human molecular genetics 10 (14), 1511-1518, 2001
Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice
CJ Cummings, E Reinstein, Y Sun, B Antalffy, Y Jiang, A Ciechanover, ...
Neuron 24 (4), 879-892, 1999
Evidence for a mechanism predisposing to intergenerational CAG repeat instability in spinocerebellar ataxia type I
M Chung, LPW Ranum, LA Duvick, A Servadio, HY Zoghbi, HT Orr
Nature genetics 5 (3), 254-258, 1993
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1
HK Chen, P Fernandez-Funez, SF Acevedo, YC Lam, MD Kaytor, ...
Cell 113 (4), 457-468, 2003
Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder
PH St George-Hyslop, JL Haines, LA Farrer, R Polinsky, CV Broeckhoven, ...
Nature 347 (6289), 194-197, 1990
Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes.
MC Carroll, P Katzman, EM Alicot, BH Koller, DE Geraghty, HT Orr, ...
Proceedings of the National Academy of Sciences 84 (23), 8535-8539, 1987
Identification and characterization of the gene causing type 1 spinocerebellar ataxia
S Banfi, A Servadio, M Chung, TJ Kwiatkowski Jr, AE McCall, LA Duvick, ...
Nature genetics 7 (4), 513-520, 1994
Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1
X Lin, B Antalffy, D Kang, HT Orr, HY Zoghbi
Nature neuroscience 3 (2), 157-163, 2000
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