Functional diversity of protein phosphatase-1, a cellular economizer and reset button H Ceulemans, M Bollen Physiological reviews 84 (1), 1-39, 2004 | 864 | 2004 |
Large-scale comparison of machine learning methods for drug target prediction on ChEMBL A Mayr, G Klambauer, T Unterthiner, M Steijaert, JK Wegner, ... Chemical science 9 (24), 5441-5451, 2018 | 534 | 2018 |
Structure-based assembly of protein complexes in yeast P Aloy, B Bottcher, H Ceulemans, C Leutwein, C Mellwig, S Fischer, ... Science 303 (5666), 2026-2029, 2004 | 452 | 2004 |
The relationship between sequence and interaction divergence in proteins P Aloy, H Ceulemans, A Stark, RB Russell Journal of molecular biology 332 (5), 989-998, 2003 | 386 | 2003 |
Docking motif-guided mapping of the interactome of protein phosphatase-1 A Hendrickx, M Beullens, H Ceulemans, T Den Abt, A Van Eynde, ... Chemistry & biology 16 (4), 365-371, 2009 | 375 | 2009 |
Nucleotide pyrophosphatases/phosphodiesterases on the move M Bollen, R Gijsbers, H Ceulemans, W Stalmans, C Stefan Critical reviews in biochemistry and molecular biology 35 (6), 393-432, 2000 | 362 | 2000 |
Image-based profiling for drug discovery: due for a machine-learning upgrade? SN Chandrasekaran, H Ceulemans, JD Boyd, AE Carpenter Nature Reviews Drug Discovery 20 (2), 145-159, 2021 | 287 | 2021 |
Degeneracy and function of the ubiquitous RVXF motif that mediates binding to protein phosphatase-1 P Wakula, M Beullens, H Ceulemans, W Stalmans, M Bollen Journal of Biological Chemistry 278 (21), 18817-18823, 2003 | 263 | 2003 |
Deep learning as an opportunity in virtual screening T Unterthiner, A Mayr, G Klambauer, M Steijaert, JK Wegner, ... Proceedings of the deep learning workshop at NIPS 27, 1-9, 2014 | 247 | 2014 |
Repurposing high-throughput image assays enables biological activity prediction for drug discovery J Simm, G Klambauer, A Arany, M Steijaert, JK Wegner, E Gustin, ... Cell chemical biology 25 (5), 611-618. e3, 2018 | 226 | 2018 |
Regulator‐driven functional diversification of protein phosphatase‐1 in eukaryotic evolution H Ceulemans, W Stalmans, M Bollen Bioessays 24 (4), 371-381, 2002 | 220 | 2002 |
ExCAPE-DB: an integrated large scale dataset facilitating Big Data analysis in chemogenomics J Sun, N Jeliazkova, V Chupakhin, JF Golib-Dzib, O Engkvist, L Carlsson, ... Journal of cheminformatics 9, 1-9, 2017 | 214 | 2017 |
Structural and catalytic similarities between nucleotide pyrophosphatases/phosphodiesterases and alkaline phosphatases R Gijsbers, H Ceulemans, W Stalmans, M Bollen Journal of Biological Chemistry 276 (2), 1361-1368, 2001 | 213 | 2001 |
Virology analyses of HCV isolates from genotype 1-infected patients treated with simeprevir plus peginterferon/ribavirin in Phase IIb/III studies O Lenz, T Verbinnen, B Fevery, L Tambuyzer, L Vijgen, M Peeters, ... Journal of hepatology 62 (5), 1008-1014, 2015 | 166 | 2015 |
Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells G Banumathy, N Somaiah, R Zhang, Y Tang, J Hoffmann, M Andrake, ... Molecular and cellular biology, 2009 | 141 | 2009 |
Geminate Structures of African Cassava Mosaic Virus B Böttcher, S Unseld, H Ceulemans, RB Russell, H Jeske Journal of virology 78 (13), 6758-6765, 2004 | 141 | 2004 |
High‐parameter mass cytometry evaluation of relapsed/refractory multiple myeloma patients treated with daratumumab demonstrates immune modulation as a novel mechanism of action HC Adams III, F Stevenaert, J Krejcik, K Van der Borght, T Smets, J Bald, ... Cytometry Part A 95 (3), 279-289, 2019 | 136 | 2019 |
Substrate specificity and activity regulation of protein kinase MELK M Beullens, S Vancauwenbergh, N Morrice, R Derua, H Ceulemans, ... Journal of Biological Chemistry 280 (48), 40003-40011, 2005 | 113 | 2005 |
Structural basis for the high Ca2+ affinity of the ubiquitous SERCA2b Ca2+ pump I Vandecaetsbeek, M Trekels, M De Maeyer, H Ceulemans, E Lescrinier, ... Proceedings of the National Academy of Sciences 106 (44), 18533-18538, 2009 | 107 | 2009 |
A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts L Milligan, L Decourty, C Saveanu, J Rappsilber, H Ceulemans, ... Molecular and cellular biology 28 (17), 5446-5457, 2008 | 104 | 2008 |