Illuminating G-protein-coupling selectivity of GPCRs A Inoue, F Raimondi, FMN Kadji, G Singh, T Kishi, A Uwamizu, Y Ono, ... Cell 177 (7), 1933-1947. e25, 2019 | 524 | 2019 |
A platform of synthetic lethal gene interaction networks reveals that the GNAQ uveal melanoma oncogene controls the Hippo pathway through FAK X Feng*, N Arang*, DC Rigiracciolo, JS Lee, H Yeerna, Z Wang, ... Cancer cell 35 (3), 457-472. e5, 2019 | 233 | 2019 |
Malaria parasites target the hepatocyte receptor EphA2 for successful host infection A Kaushansky, AN Douglass, N Arang, V Vigdorovich, N Dambrauskas, ... Science 350 (6264), 1089-1092, 2015 | 141 | 2015 |
G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers N Arang, JS Gutkind FEBS letters 594 (24), 4201-4232, 2020 | 129 | 2020 |
Liver stage malaria infection is controlled by host regulators of lipid peroxidation HS Kain, EKK Glennon, K Vijayan, N Arang, AN Douglass, CL Fortin, ... Cell Death & Differentiation 27 (1), 44-54, 2020 | 76 | 2020 |
Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma JS Paradis, M Acosta, R Saddawi-Konefka, A Kishore, S Lubrano, ... Clinical Cancer Research 27 (11), 3190-3200, 2021 | 69 | 2021 |
Gαs–Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gαs-PKA Signaling DJ Ramms, F Raimondi, N Arang, FW Herberg, SS Taylor, JS Gutkind Pharmacological Reviews 73 (4), 155-197, 2021 | 52 | 2021 |
EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1 T Ando, N Arang, Z Wang, DE Costea, X Feng, Y Goto, H Izumi, M Gilardi, ... Communications Biology 4 (1), 1237, 2021 | 46 | 2021 |
Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles N Arang, HS Kain, EK Glennon, T Bello, DR Dudgeon, ENF Walter, ... Nature communications 8 (1), 1232, 2017 | 39 | 2017 |
SSP3 is a novel Plasmodium yoelii sporozoite surface protein with a role in gliding motility A Harupa, BK Sack, V Lakshmanan, N Arang, AN Douglass, BG Oliver, ... Infection and immunity 82 (11), 4643-4653, 2014 | 39 | 2014 |
Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK–YAP signaling axis Y Goto, T Ando, H Izumi, X Feng, N Arang, M Gilardi, Z Wang, K Ando, ... Oncogene 39 (20), 4014-4027, 2020 | 36 | 2020 |
Host-based prophylaxis successfully targets liver stage malaria parasites AN Douglass, HS Kain, M Abdullahi, N Arang, LS Austin, SA Mikolajczak, ... Molecular Therapy 23 (5), 857-865, 2015 | 36 | 2015 |
Focal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer (TNBC) DC Rigiracciolo, N Nohata, R Lappano, F Cirillo, M Talia, ... Journal of Experimental & Clinical Cancer Research 41 (1), 193, 2022 | 35 | 2022 |
Susceptibility to Plasmodium yoelii preerythrocytic infection in BALB/c substrains is determined at the point of hepatocyte invasion A Kaushansky, LS Austin, SA Mikolajczak, FY Lo, JL Miller, AN Douglass, ... Infection and immunity 83 (1), 39-47, 2015 | 27 | 2015 |
Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential SJ Bandekar, N Arang, ES Tully, BA Tang, BL Barton, S Li, JS Gutkind, ... Science signaling 12 (569), eaav2449, 2019 | 26 | 2019 |
A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection K Vijayan, N Arang, L Wei, R Morrison, R Geiger, KR Parks, AJ Lewis, ... Cell chemical biology 29 (9), 1419-1433. e5, 2022 | 19 | 2022 |
Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ–focal adhesion kinase signaling circuitry N Arang, S Lubrano, DC Rigiracciolo, D Nachmanson, SM Lippman, ... Journal of Biological Chemistry 299 (2), 2022 | 13 | 2022 |
Alterations in phosphorylation of hepatocyte ribosomal protein S6 control plasmodium liver stage infection EKK Glennon, LS Austin, N Arang, HS Kain, FD Mast, K Vijayan, ... Cell reports 26 (12), 3391-3399. e4, 2019 | 13 | 2019 |
Catalytic site mutations confer multiple states of G protein activation N Hewitt, N Ma, N Arang, SA Martin, A Prakash, JF DiBerto, KM Knight, ... Science signaling 16 (772), eabq7842, 2023 | 12 | 2023 |
High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma N Arang, S Lubrano, M Ceribelli, DC Rigiracciolo, R Saddawi-Konefka, ... Cell Reports Medicine 4 (11), 2023 | 10 | 2023 |