Class I histone deacetylases (HDAC1–3) are histone lysine delactylases C Moreno-Yruela, D Zhang, W Wei, M Bæk, W Liu, J Gao, D Danková, ... Science advances 8 (3), eabi6696, 2022 | 160 | 2022 |
Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer … AL Nielsen, N Rajabi, N Kudo, K Lundø, C Moreno-Yruela, M Bæk, ... RSC Chemical Biology 2 (2), 612-626, 2021 | 32 | 2021 |
Recent achievements in developing selective Gq inhibitors H Zhang, AL Nielsen, K Strømgaard Medicinal research reviews 40 (1), 135-157, 2020 | 32 | 2020 |
Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359 H Zhang, AL Nielsen, MW Boesgaard, K Harpsøe, NL Daly, XF Xiong, ... European journal of medicinal chemistry 156, 847-860, 2018 | 29 | 2018 |
Cyclic peptides for drug development X Ji, AL Nielsen, C Heinis Angewandte Chemie International Edition 63 (3), e202308251, 2024 | 22 | 2024 |
Catch and anchor approach to combat both toxicity and longevity of botulinum toxin A L Lin, ME Olson, T Sugane, LD Turner, MA Tararina, AL Nielsen, ... Journal of medicinal chemistry 63 (19), 11100-11120, 2020 | 18 | 2020 |
Investigation of Carboxylic Acid Isosteres and Prodrugs for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme N Rajabi, TN Hansen, AL Nielsen, HT Nguyen, M Bæk, JE Bolding, ... Angewandte Chemie 134 (22), e202115805, 2022 | 17 | 2022 |
Dethioacylation by sirtuins 1–3: considerations for drug design using mechanism-based sirtuin inhibition N Rajabi, AL Nielsen, CA Olsen ACS Medicinal Chemistry Letters 11 (10), 1886-1892, 2020 | 17 | 2020 |
Neurotrophic effects of vascular endothelial growth factor B and novel mimetic peptides on neurons from the central nervous system O Dmytriyeva, A de Diego Ajenjo, K Lundø, H Hertz, KK Rasmussen, ... ACS Chemical Neuroscience 11 (9), 1270-1282, 2020 | 14 | 2020 |
Mitochondria-targeted inhibitors of the human SIRT3 lysine deacetylase KS Troelsen, M Bæk, AL Nielsen, AS Madsen, N Rajabi, CA Olsen RSC Chemical Biology 2 (2), 627-635, 2021 | 11 | 2021 |
Solid-phase peptide synthesis on disulfide-linker resin followed by reductive release affords pure thiol-functionalized peptides Z Bognar, GK Mothukuri, AL Nielsen, ML Merz, PMF Pânzar, C Heinis Organic & Biomolecular Chemistry 20 (29), 5699-5703, 2022 | 10 | 2022 |
Irreversible inhibition of BoNT/A protease: proximity-driven reactivity contingent upon a bifunctional approach LD Turner, AL Nielsen, L Lin, S Pellett, T Sugane, ME Olson, EA Johnson, ... RSC medicinal chemistry 12 (6), 960-969, 2021 | 10 | 2021 |
Use of crystallography and molecular modeling for the inhibition of the botulinum neurotoxin A protease LD Turner, AL Nielsen, L Lin, AJ Campedelli, NR Silvaggi, JS Chen, ... ACS Medicinal Chemistry Letters 12 (8), 1318-1324, 2021 | 3 | 2021 |
Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide Activated Sirtuin 7 JE Bolding, AL Nielsen, I Jensen, TN Hansen, LA Ryberg, ST Jameson, ... Angewandte Chemie International Edition, e202314597, 2023 | 2 | 2023 |
Transformation of a Metal Chelate into a “Catch and Anchor” Inhibitor of Botulinum A Protease L Lin, EN Patel, AL Nielsen, LD Turner, WH Tepp, K Nguyen, S Pellett, ... International Journal of Molecular Sciences 24 (5), 4303, 2023 | 2 | 2023 |
Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay RJ Shirey, JR Hart, BP Sridharan, SJ Novick, LD Turner, B Zhou, ... Bioorganic & medicinal chemistry 42, 116246, 2021 | 2 | 2021 |
Finding the gas pedal on a slow sirtuin AL Nielsen, CA Olsen Journal of Biological Chemistry 295 (5), 1400-1401, 2020 | 1 | 2020 |
Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation AL Nielsen, Z Bognar, GK Mothukuri, A Zarda, M Schuttel, ML Merz, X Ji, ... Angewandte Chemie, e202400350, 2024 | | 2024 |
Solid‐phase peptide synthesis in 384‐well plates M Schüttel, E Will, G Sangouard, A Zarda, S Habeshian, AL Nielsen, ... Journal of Peptide Science, e3555, 2024 | | 2024 |
Nanomole‐scale photochemical thiol‐ene chemistry for high‐throughput late‐stage diversification of peptide macrocycles MD Nolan, M Schüttel, EM Scanlan, AL Nielsen Peptide Science 116 (1), e24310, 2024 | | 2024 |