Robert J. Lefkowitz
Robert J. Lefkowitz
James B. Duke Professor of Medicine, Biochemistry, Chemistry; HHMI, Duke University
Verified email at - Homepage
Cited by
Cited by
Goodman and Gilman's the pharmacological basis of therapeutics
AG Gilman
Seven-transmembrane receptors
KL Pierce, RT Premont, RJ Lefkowitz
Nature reviews Molecular cell biology 3 (9), 639-650, 2002
A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.
A De Lean, JM Stadel, RJ Lefkowitz
Journal of Biological Chemistry 255 (15), 7108-7117, 1980
Transduction of receptor signals by ß-arrestins
RJ Lefkowitz, SK Shenoy
Science 308 (5721), 512-517, 2005
Model systems for the study of seven-transmembrane-segment receptors
HG Dohlman, J Thorner, MG Caron, RJ Lefkowitz
Annual review of biochemistry 60 (1), 653-688, 1991
β-Arrestin-dependent formation of β2 adrenergic receptor-Src protein kinase complexes
LM Luttrell, S Ferguson, Y Daaka, WE Miller, S Maudsley, GJ Della Rocca, ...
Science 283 (5402), 655-661, 1999
Turning off the signal: desensitization of β‐adrenergic receptor function
WP Hausdorff, MG Caron, RJ Lefkowitz
The FASEB Journal 4 (11), 2881-2889, 1990
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin
RAF Dixon, BK Kobilka, DJ Strader, JL Benovic, HG Dohlman, T Frielle, ...
Nature 321 (6065), 75-79, 1986
A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.
P Samama, S Cotecchia, T Costa, RJ Lefkowitz
Journal of Biological Chemistry 268 (7), 4625-4636, 1993
G protein–coupled receptor kinases
JA Pitcher, NJ Freedman, RJ Lefkowitz
Annual review of biochemistry 67 (1), 653-692, 1998
Switching of the coupling of the β 2-adrenergic receptor to different G proteins by protein kinase A
Y Daaka, LM Luttrell, RJ Lefkowitz
Nature 390 (6655), 88-91, 1997
International Union of Pharmacology nomenclature of adrenoceptors
DB Bylund
Pharmacol. Rev. 46, 121-136, 1994
β-Arrestins and cell signaling
SM DeWire, S Ahn, RJ Lefkowitz, SK Shenoy
Annu. Rev. Physiol. 69, 483-510, 2007
beta-Arrestin: a protein that regulates beta-adrenergic receptor function
MJ Lohse, JL Benovic, J Codina, MG Caron, RJ Lefkowitz
Science 248 (4962), 1547-1550, 1990
G protein-coupled receptors: III. New roles for receptor kinases and β-arrestins in receptor signaling and desensitization
RJ Lefkowitz
Journal of Biological Chemistry 273 (30), 18677-18680, 1998
The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals
LM Luttrell, RJ Lefkowitz
Journal of cell science 115 (3), 455-465, 2002
Seven-transmembrane-spanning receptors and heart function
HA Rockman, WJ Koch, RJ Lefkowitz
Nature 415 (6868), 206-212, 2002
An Akt/β-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
JM Beaulieu, TD Sotnikova, S Marion, RJ Lefkowitz, RR Gainetdinov, ...
Cell 122 (2), 261-273, 2005
Chimeric alpha 2-, beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity
BK Kobilka, TS Kobilka, K Daniel, JW Regan, MG Caron, RJ Lefkowitz
Science 240 (4857), 1310-1316, 1988
Enhanced morphine analgesia in mice lacking β-arrestin 2
LM Bohn, RJ Lefkowitz, RR Gainetdinov, K Peppel, MG Caron, FT Lin
Science 286 (5449), 2495-2498, 1999
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