Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis S Sawcer, G Hellenthal, M Pirinen, CCA Spencer, NA Patsopoulos, ... Nature 476 (7359), 214, 2011 | 2617 | 2011 |
Nanopore sequencing and assembly of a human genome with ultra-long reads M Jain, S Koren, KH Miga, J Quick, AC Rand, TA Sasani, JR Tyson, ... Nature biotechnology 36 (4), 338-345, 2018 | 1298 | 2018 |
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis AH Beecham, NA Patsopoulos, DK Xifara, MF Davis, A Kemppinen, ... Nature genetics 45 (11), 1353, 2013 | 1096 | 2013 |
Genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1 A Strange, F Capon, CCA Spencer, J Knight, ME Weale, MH Allen, ... Nature genetics 42 (11), 985, 2010 | 955 | 2010 |
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility DM Evans, CCA Spencer, JJ Pointon, Z Su, D Harvey, G Kochan, ... Nature genetics 43 (8), 761-767, 2011 | 841 | 2011 |
Severe COVID-19 is marked by a dysregulated myeloid cell compartment J Schulte-Schrepping, N Reusch, D Paclik, K Baßler, S Schlickeiser, ... Cell 182 (6), 1419-1440. e23, 2020 | 677 | 2020 |
Genetics of gene expression in primary immune cells identifies cell type–specific master regulators and roles of HLA alleles BP Fairfax, S Makino, J Radhakrishnan, K Plant, S Leslie, A Dilthey, ... Nature genetics 44 (5), 502-510, 2012 | 508 | 2012 |
Class II HLA interactions modulate genetic risk for multiple sclerosis L Moutsianas, L Jostins, AH Beecham, AT Dilthey, DK Xifara, M Ban, ... Nature genetics 47 (10), 1107, 2015 | 292 | 2015 |
SARS‐CoV‐2 targets neurons of 3D human brain organoids A Ramani, L Müller, PN Ostermann, E Gabriel, P Abida‐Islam, ... The EMBO journal 39 (20), e106230, 2020 | 251 | 2020 |
De novo assembly of haplotype-resolved genomes with trio binning S Koren, A Rhie, BP Walenz, AT Dilthey, DM Bickhart, SB Kingan, ... Nature biotechnology 36 (12), 1174-1182, 2018 | 222 | 2018 |
Improved genome inference in the MHC using a population reference graph A Dilthey, C Cox, Z Iqbal, MR Nelson, G McVean Nature genetics 47 (6), 682-688, 2015 | 202 | 2015 |
Improved genome inference in the MHC using a population reference graph A Dilthey, C Cox, Z Iqbal, MR Nelson, G McVean Nature genetics 47 (6), 682-688, 2015 | 202 | 2015 |
HLA* IMP—an integrated framework for imputing classical HLA alleles from SNP genotypes AT Dilthey, L Moutsianas, S Leslie, G McVean Bioinformatics 27 (7), 968-972, 2011 | 165 | 2011 |
Multi-population classical HLA type imputation A Dilthey, S Leslie, L Moutsianas, J Shen, C Cox, MR Nelson, G McVean PLoS computational biology 9 (2), e1002877, 2013 | 164 | 2013 |
Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells, and plasmablasts as hallmarks of severe COVID-19 JP Bernardes, N Mishra, F Tran, T Bahmer, L Best, JI Blase, D Bordoni, ... Immunity 53 (6), 1296-1314. e9, 2020 | 132 | 2020 |
DNA methylation as a mediator of HLA-DRB1* 15: 01 and a protective variant in multiple sclerosis L Kular, Y Liu, S Ruhrmann, G Zheleznyakova, F Marabita, ... Nature communications 9 (1), 1-15, 2018 | 111 | 2018 |
A fast approximate algorithm for mapping long reads to large reference databases C Jain, A Dilthey, S Koren, S Aluru, AM Phillippy International Conference on Research in Computational Molecular Biology, 66-81, 2017 | 86 | 2017 |
High-accuracy HLA type inference from whole-genome sequencing data using population reference graphs AT Dilthey, PA Gourraud, AJ Mentzer, N Cereb, Z Iqbal, G McVean PLoS computational biology 12 (10), e1005151, 2016 | 84 | 2016 |
A fast adaptive algorithm for computing whole-genome homology maps C Jain, S Koren, A Dilthey, AM Phillippy, S Aluru Bioinformatics 34 (17), i748-i756, 2018 | 75 | 2018 |
Psoriasis patients are enriched for genetic variants that protect against HIV-1 disease H Chen, G Hayashi, OY Lai, A Dilthey, PJ Kuebler, TV Wong, MP Martin, ... PLoS genetics 8 (2), e1002514, 2012 | 73 | 2012 |