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William Israelsen
William Israelsen
Israelsen Lab
Verified email at israelsenlab.org - Homepage
Title
Cited by
Cited by
Year
Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages
EM Palsson-McDermott, AM Curtis, G Goel, MAR Lauterbach, FJ Sheedy, ...
Cell metabolism 21 (1), 65-80, 2015
10822015
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
D Anastasiou, Y Yu, WJ Israelsen, JK Jiang, MB Boxer, BS Hong, ...
Nature chemical biology 8 (10), 839-847, 2012
7652012
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells
WJ Israelsen, TL Dayton, SM Davidson, BP Fiske, AM Hosios, G Bellinger, ...
Cell 155 (2), 397-409, 2013
5342013
Pyruvate kinase: Function, regulation and role in cancer
WJ Israelsen, MG Vander Heiden
Seminars in cell & developmental biology 43, 43-51, 2015
5152015
Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction
W Qi, HA Keenan, Q Li, A Ishikado, A Kannt, T Sadowski, MA Yorek, ...
Nature medicine 23 (6), 753-762, 2017
3742017
Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis
YH Wang, WJ Israelsen, D Lee, WC Vionnie, NT Jeanson, CB Clish, ...
Cell 158 (6), 1309-1323, 2014
3562014
Metabolic pathway alterations that support cell proliferation
MG Vander Heiden, SY Lunt, TL Dayton, BP Fiske, WJ Israelsen, ...
Cold Spring Harbor symposia on quantitative biology 76, 325-334, 2011
3262011
Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation
SY Lunt, V Muralidhar, AM Hosios, WJ Israelsen, DY Gui, L Newhouse, ...
Molecular cell 57 (1), 95-107, 2015
2432015
Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma
TL Dayton, V Gocheva, KM Miller, WJ Israelsen, A Bhutkar, CB Clish, ...
Genes & development 30 (9), 1020-1033, 2016
1362016
ML265: A potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model
J Jiang, MJ Walsh, KR Brimacombe, D Anastasiou, Y Yu, WJ Israelsen, ...
Probe Reports from the NIH Molecular Libraries Program [Internet], 2013
762013
2-Oxo-N-aryl-1, 2, 3, 4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase
MJ Walsh, KR Brimacombe, H Veith, JM Bougie, T Daniel, W Leister, ...
Bioorganic & medicinal chemistry letters 21 (21), 6322-6327, 2011
712011
ATP consumption promotes cancer metabolism
WJ Israelsen, MG Vander Heiden
Cell 143 (5), 669-671, 2010
602010
PKM2 is not required for colon cancer initiated by APC loss
AN Lau, WJ Israelsen, J Roper, MJ Sinnamon, L Georgeon, TL Dayton, ...
Cancer & metabolism 5, 1-7, 2017
392017
Cancer‐associated mutations in human pyruvate kinase M2 impair enzyme activity
VM Liu, AJ Howell, AM Hosios, Z Li, WJ Israelsen, MG Vander Heiden
FEBS letters 594 (4), 646-664, 2020
172020
Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma
SM Davidson, DR Schmidt, JE Heyman, JP O'Brien, AC Liu, WJ Israelsen, ...
Cancer research 82 (13), 2403-2416, 2022
162022
Fibroblasts as an experimental model system for the study of comparative physiology
CB Madelaire, AC Klink, WJ Israelsen, AG Hindle
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular …, 2022
112022
Nesting box imager: Contact-free, real-time measurement of activity, surface body temperature, and respiratory rate applied to hibernating mouse models
NE Kallmyer, HJ Shin, EA Brem, WJ Israelsen, NF Reuel
PLoS Biology 17 (7), e3000406, 2019
112019
Breeding and hibernation of captive meadow jumping mice (Zapus hudsonius)
EA Brem, AD McNulty, WJ Israelsen
Plos one 16 (5), e0240706, 2021
62021
Cutaneous dermatophilosis in a meadow jumping mouse (Zapus hudsonius)
TJ Caron, SC Artim, WJ Israelsen, HR Holcombe, JG Fox, ...
Comparative Medicine 68 (1), 25-30, 2018
52018
Differential dependence on aerobic glycolysis in normal and malignant hematopoietic stem and progenitor cells to sustain daughter cell production
YH Wang, WJ Israelsen, D Lee, WC Vionnie, NT Jeanson, CB Clish, ...
Blood 122 (21), 793, 2013
52013
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