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Aaron M. Hosios
Aaron M. Hosios
Unknown affiliation
Verified email at hsph.harvard.edu
Title
Cited by
Cited by
Year
Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells
LB Sullivan, DY Gui, AM Hosios, LN Bush, E Freinkman, ...
Cell 162 (3), 552-563, 2015
10492015
Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells
AM Hosios, VC Hecht, LV Danai, MO Johnson, JC Rathmell, ...
Developmental cell 36 (5), 540-549, 2016
6072016
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells
WJ Israelsen, TL Dayton, SM Davidson, BP Fiske, AM Hosios, G Bellinger, ...
Cell 155 (2), 397-409, 2013
5342013
Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
JR Mayers, ME Torrence, LV Danai, T Papagiannakopoulos, ...
Science 353 (6304), 1161-1165, 2016
5292016
Environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin
DY Gui, LB Sullivan, A Luengo, AM Hosios, LN Bush, N Gitego, ...
Cell metabolism 24 (5), 716-727, 2016
3142016
Aspartate is an endogenous metabolic limitation for tumour growth
LB Sullivan, A Luengo, LV Danai, LN Bush, FF Diehl, AM Hosios, AN Lau, ...
Nature cell biology 20 (7), 782-788, 2018
2812018
Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation
SY Lunt, V Muralidhar, AM Hosios, WJ Israelsen, DY Gui, L Newhouse, ...
Molecular cell 57 (1), 95-107, 2015
2432015
The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
ME Torrence, MR MacArthur, AM Hosios, AJ Valvezan, JM Asara, ...
Elife 10, e63326, 2021
1182021
The redox requirements of proliferating mammalian cells
AM Hosios, MG Vander Heiden
Journal of Biological Chemistry 293 (20), 7490-7498, 2018
1152018
Pyrimidine homeostasis is accomplished by directed overflow metabolism
ML Reaves, BD Young, AM Hosios, YF Xu, JD Rabinowitz
Nature 500 (7461), 237-241, 2013
1152013
Lack of evidence for PKM2 protein kinase activity
AM Hosios, BP Fiske, DY Gui, MG Vander Heiden
Molecular cell 59 (5), 850-857, 2015
1052015
Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth
AG Cox, A Tsomides, D Yimlamai, KL Hwang, J Miesfeld, GG Galli, ...
The EMBO journal 37 (22), e100294, 2018
832018
Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer
A Luengo, KL Abbott, SM Davidson, AM Hosios, B Faubert, SH Chan, ...
Nature communications 10 (1), 5604, 2019
512019
Acetate metabolism in cancer cells
AM Hosios, MG Vander Heiden
Cancer & metabolism 2, 1-2, 2014
392014
A New System for Comparative Functional Genomics of Saccharomyces Yeasts
AA Caudy, Y Guan, Y Jia, C Hansen, C DeSevo, AP Hayes, J Agee, ...
Genetics 195 (1), 275-287, 2013
332013
Cancer signaling drives cancer metabolism: AKT and the warburg effect
AM Hosios, BD Manning
Cancer Research 81 (19), 4896-4898, 2021
322021
Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited
Z Li, BW Ji, PD Dixit, K Tchourine, EC Lien, AM Hosios, KL Abbott, ...
Nature metabolism 4 (6), 711-723, 2022
262022
Cooperative nutrient accumulation sustains growth of mammalian cells
S Son, MM Stevens, HX Chao, C Thoreen, AM Hosios, LD Schweitzer, ...
Scientific reports 5 (1), 17401, 2015
232015
Biophysical changes reduce energetic demand in growth factor–deprived lymphocytes
VC Hecht, LB Sullivan, RJ Kimmerling, DH Kim, AM Hosios, ...
Journal of Cell Biology 212 (4), 439-447, 2016
222016
Cancer‐associated mutations in human pyruvate kinase M2 impair enzyme activity
VM Liu, AJ Howell, AM Hosios, Z Li, WJ Israelsen, MG Vander Heiden
FEBS letters 594 (4), 646-664, 2020
172020
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Articles 1–20