Ryan Watts
Ryan Watts
Denali Therapeutics
Verified email at - Homepage
Cited by
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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
T Jonsson, JK Atwal, S Steinberg, J Snaedal, PV Jonsson, S Bjornsson, ...
Nature 488 (7409), 96-99, 2012
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
J Ridgway, G Zhang, Y Wu, S Stawicki, WC Liang, Y Chanthery, ...
Nature 444 (7122), 1083-1087, 2006
Therapeutic antibody targeting of individual Notch receptors
Y Wu, C Cain-Hom, L Choy, TJ Hagenbeek, GP De Leon, Y Chen, ...
Nature 464 (7291), 1052-1057, 2010
Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target
YJ Yu, Y Zhang, M Kenrick, K Hoyte, W Luk, Y Lu, J Atwal, JM Elliott, ...
Science translational medicine 3 (84), 84ra44-84ra44, 2011
Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth
Q Pan, Y Chanthery, WC Liang, S Stawicki, J Mak, N Rathore, RK Tong, ...
Cancer cell 11 (1), 53-67, 2007
Engaging neuroscience to advance translational research in brain barrier biology
EA Neuwelt, B Bauer, C Fahlke, G Fricker, C Iadecola, D Janigro, ...
Nature Reviews Neuroscience 12 (3), 169-182, 2011
The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons
JM MacDonald, MG Beach, E Porpiglia, AE Sheehan, RJ Watts, ...
Neuron 50 (6), 869-881, 2006
Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome system
RJ Watts, ED Hoopfer, L Luo
Neuron 38 (6), 871-885, 2003
TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge
AA Nugent, K Lin, B Van Lengerich, S Lianoglou, L Przybyla, SS Davis, ...
Neuron 105 (5), 837-854. e9, 2020
Blocking neuropilin-2 function inhibits tumor cell metastasis
M Caunt, J Mak, WC Liang, S Stawicki, Q Pan, RK Tong, J Kowalski, C Ho, ...
Cancer cell 13 (4), 331-342, 2008
Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration
Q Zhai, J Wang, A Kim, Q Liu, R Watts, E Hoopfer, T Mitchison, L Luo, ...
Neuron 39 (2), 217-225, 2003
An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ
O Adolfsson, M Pihlgren, N Toni, Y Varisco, AL Buccarello, K Antoniello, ...
Journal of Neuroscience 32 (28), 9677-9689, 2012
Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
YJ Yu, JK Atwal, Y Zhang, RK Tong, KR Wildsmith, C Tan, N Bien-Ly, ...
Science translational medicine 6 (261), 261ra154-261ra154, 2014
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
F Zhang, Z Tang, X Hou, J Lennartsson, Y Li, AW Koch, P Scotney, C Lee, ...
Proceedings of the National Academy of Sciences 106 (15), 6152-6157, 2009
Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants
N Bien-Ly, YJ Yu, D Bumbaca, J Elstrott, CA Boswell, Y Zhang, W Luk, ...
Journal of Experimental Medicine 211 (2), 233-244, 2014
A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo
JK Atwal, Y Chen, C Chiu, DL Mortensen, WJ Meilandt, Y Liu, CE Heise, ...
Science translational medicine 3 (84), 84ra43-84ra43, 2011
Effect of selective LRRK2 kinase inhibition on nonhuman primate lung
RN Fuji, M Flagella, M Baca, MA S. Baptista, J Brodbeck, BK Chan, ...
Science translational medicine 7 (273), 273ra15-273ra15, 2015
Wlds protection distinguishes axon degeneration following injury from naturally occurring developmental pruning
ED Hoopfer, T McLaughlin, RJ Watts, O Schuldiner, DDM O'Leary, L Luo
Neuron 50 (6), 883-895, 2006
Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting
Q Pan, Y Chathery, Y Wu, N Rathore, RK Tong, F Peale, A Bagri, ...
Journal of Biological Chemistry 282 (33), 24049-24056, 2007
Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier
JA Couch, YJ Yu, Y Zhang, JM Tarrant, RN Fuji, WJ Meilandt, H Solanoy, ...
Science translational medicine 5 (183), 183ra57-183ra57, 2013
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