| Multitarget drug design strategy: quinone–tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects E Nepovimova, E Uliassi, J Korabecny, LE Pena-Altamira, S Samez, ... Journal of medicinal chemistry 57 (20), 8576-8589, 2014 | 187 | 2014 |
| Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease J Jeřábek, E Uliassi, L Guidotti, J Korábečný, O Soukup, V Sepsova, ... European Journal of Medicinal Chemistry 127, 250-262, 2017 | 114 | 2017 |
| Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss MA White, Z Lin, E Kim, CM Henstridge, E Pena Altamira, CK Hunt, ... Acta neuropathologica communications 7, 1-16, 2019 | 70 | 2019 |
| New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents JM Roldan-Pena, D Alejandre-Ramos, O Lopez, I Maya, I Lagunes, ... European journal of medicinal chemistry 138, 761-773, 2017 | 68 | 2017 |
| Changing paradigm to target microglia in neurodegenerative diseases: from anti-inflammatory strategy to active immunomodulation E Pena-Altamira, F Prati, F Massenzio, M Virgili, A Contestabile, ... Expert opinion on therapeutic targets 20 (5), 627-640, 2016 | 68 | 2016 |
| Neuroprotection of microglial conditioned medium on 6‐hydroxydopamine‐induced neuronal death: role of transforming growth factor beta‐2 E Polazzi, LEP Altamira, S Eleuteri, R Barbaro, C Casadio, A Contestabile, ... Journal of neurochemistry 110 (2), 545-556, 2009 | 57 | 2009 |
| Long‐term dietary administration of valproic acid does not affect, while retinoic acid decreases, the lifespan of G93A mice, a model for amyotrophic lateral sclerosis C Crochemore, M Virgili, B Bonamassa, D Canistro, E Pena‐Altamira, ... Muscle & nerve 39 (4), 548-552, 2009 | 53 | 2009 |
| Nutritional and pharmacological strategies to regulate microglial polarization in cognitive aging and Alzheimer’s disease E Peña-Altamira, S Petralla, F Massenzio, M Virgili, ML Bolognesi, ... Frontiers in aging neuroscience 9, 175, 2017 | 46 | 2017 |
| Microglial overexpression of fALS-linked mutant SOD1 induces SOD1 processing impairment, activation and neurotoxicity and is counteracted by the autophagy inducer trehalose F Massenzio, E Peña-Altamira, S Petralla, M Virgili, G Zuccheri, A Miti, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1864 (12 …, 2018 | 36 | 2018 |
| MBNL142 and MBNL143 gene isoforms, overexpressed in DM1-patient muscle, encode for nuclear proteins interacting with Src family kinases A Botta, A Malena, E Tibaldi, L Rocchi, E Loro, E Pena, L Cenci, ... Cell Death & Disease 4 (8), e770-e770, 2013 | 35 | 2013 |
| Tissue distribution and metabolism of guanosine in rats following intraperitoneal injection. P Giuliani, P Ballerini, R Ciccarelli, S Buccella, S Romano, I D'Alimonte, ... Journal of biological regulators and homeostatic agents 26 (1), 51-65, 2012 | 32 | 2012 |
| Transcriptional profiling in the lumbar spinal cord of a mouse model of amyotrophic lateral sclerosis: a role for wild-type superoxide dismutase 1 in sporadic disease? A D’Arrigo, D Colavito, E Peña-Altamira, M Fabris, M Dam, A Contestabile, ... Journal of molecular neuroscience 41, 404-415, 2010 | 32 | 2010 |
| Copper-zinc superoxide dismutase (SOD1) is released by microglial cells and confers neuroprotection against 6-OHDA neurotoxicity E Polazzi, I Mengoni, M Caprini, E Peña-Altamira, E Kurtys, B Monti Neurosignals 21 (1-2), 112-128, 2013 | 31 | 2013 |
| Neurochemical correlates of differential neuroprotection by long-term dietary creatine supplementation E Peña-Altamira, C Crochemore, M Virgili, A Contestabile Brain research 1058 (1-2), 183-188, 2005 | 31 | 2005 |
| Down-regulation of the mitochondrial aspartate-glutamate carrier isoform 1 AGC1 inhibits proliferation and N-acetylaspartate synthesis in Neuro2A cells E Profilo, LE Peña-Altamira, M Corricelli, A Castegna, A Danese, G Agrimi, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1863 (6 …, 2017 | 28 | 2017 |
| The transcription factor CCAAT enhancer‐binding protein β protects rat cerebellar granule neurons from apoptosis through its transcription‐activating isoforms E Peña‐Altamira, E Polazzi, E Moretto, M Lauriola, B Monti European Journal of Neuroscience 39 (2), 176-185, 2014 | 26 | 2014 |
| Disease-related regressive alterations of forebrain cholinergic system in SOD1 mutant transgenic mice C Crochemore, E Peña-Altamira, M Virgili, B Monti, A Contestabile Neurochemistry international 46 (5), 357-368, 2005 | 26 | 2005 |
| Release of soluble and vesicular purine nucleoside phosphorylase from rat astrocytes and microglia induced by pro-inflammatory stimulation with extracellular ATP via P2X7 receptors LE Pena-Altamira, E Polazzi, P Giuliani, A Beraudi, F Massenzio, ... Neurochemistry international 115, 37-49, 2018 | 25 | 2018 |
| Histone post-translational modifications in Huntington’s and Parkinson’s diseases L Emiliano Pena-Altamira, E Polazzi, B Monti Current pharmaceutical design 19 (28), 5085-5092, 2013 | 23 | 2013 |
| Nitric oxide control of proliferation in nerve cells and in tumor cells of nervous origin E Pena-Altamira, P Petazzi, A Contestabile Current pharmaceutical design 16 (4), 440-450, 2010 | 23 | 2010 |
