Isaac Alexander Chaim
Isaac Alexander Chaim
Postdoctoral Fellow. Sanford Consortium for Regenerative Medicine. UC San Diego. La Jolla, CA
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Cited by
Complex oscillatory waves emerging from cortical organoids model early human brain network development
CA Trujillo, R Gao, PD Negraes, J Gu, J Buchanan, S Preissl, A Wang, ...
Cell stem cell 25 (4), 558-569. e7, 2019
Elimination of toxic microsatellite repeat expansion RNA by RNA-targeting Cas9
R Batra, DA Nelles, E Pirie, SM Blue, RJ Marina, H Wang, IA Chaim, ...
Cell 170 (5), 899-912. e10, 2017
Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis
ZD Nagel, CM Margulies, IA Chaim, SK McRee, P Mazzucato, A Ahmad, ...
Proceedings of the National Academy of Sciences 111 (18), E1823-E1832, 2014
DNA repair capacity in multiple pathways predicts chemoresistance in glioblastoma multiforme
ZD Nagel, GJ Kitange, SK Gupta, BA Joughin, IA Chaim, P Mazzucato, ...
Cancer research 77 (1), 198-206, 2017
Inter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair research
ZD Nagel, IA Chaim, LD Samson
DNA repair 19, 199-213, 2014
In vivo measurements of interindividual differences in DNA glycosylases and APE1 activities
IA Chaim, ZD Nagel, JJ Jordan, P Mazzucato, LP Ngo, LD Samson
Proceedings of the National Academy of Sciences 114 (48), E10379-E10388, 2017
Evaluation of the potential of novel PCL–PPDX biodegradable scaffolds as support materials for cartilage tissue engineering
IA Chaim, MA Sabino, M Mendt, AJ Müller, D Ajami
Journal of tissue engineering and regenerative medicine 6 (4), 272-279, 2012
Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells
T Koga, IA Chaim, JA Benitez, S Markmiller, AD Parisian, RF Hevner, ...
Nature communications 11 (1), 1-14, 2020
Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment
CA Trujillo, ES Rice, NK Schaefer, IA Chaim, EC Wheeler, AA Madrigal, ...
Science 371 (6530), 2021
A novel role for transcription-coupled nucleotide excision repair for the in vivo repair of 3,N4-ethenocytosine
IA Chaim, A Gardner, J Wu, T Iyama, DM Wilson III, LD Samson
Nucleic acids research 45 (6), 3242-3252, 2017
Nitric oxide induced S-nitrosation causes base excision repair imbalance
MC Parrish, IA Chaim, ZD Nagel, SR Tannenbaum, LD Samson, ...
DNA repair 68, 25-33, 2018
Alkylation induced cerebellar degeneration dependent on Aag and Parp1 does not occur via previously established cell death mechanisms
CM Margulies, IA Chaim, A Mazumder, J Criscione, LD Samson
PloS one 12 (9), e0184619, 2017
Robust single-cell discovery of RNA targets of RNA binding proteins and ribosomes
K Brannan, I Chaim, B Yee, R Marina, D Lorenz, K Dong, A Madrigal, ...
Assessing BER capacity in the human population
IA Chaim, ZD Nagel
The Base Excision Repair Pathway: Molecular Mechanisms and Role in Disease …, 2017
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