moshe goldsmith
moshe goldsmith
Associate Staff Scientist, Weizmann Institute of Science
Verified email at weizmann.ac.il
Title
Cited by
Cited by
Year
Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis
SD Khare, Y Kipnis, R Takeuchi, Y Ashani, M Goldsmith, Y Song, ...
Nature chemical biology 8 (3), 294-300, 2012
2232012
Quantitative analysis of translesion DNA synthesis across a benzo [a] pyrene-guanine adduct in mammalian cells: the role of DNA polymerase κ
S Avkin, M Goldsmith, S Velasco-Miguel, N Geacintov, EC Friedberg, ...
Journal of Biological Chemistry 279 (51), 53298-53305, 2004
2062004
Automated structure-and sequence-based design of proteins for high bacterial expression and stability
A Goldenzweig, M Goldsmith, SE Hill, O Gertman, P Laurino, Y Ashani, ...
Molecular cell 63 (2), 337-346, 2016
1942016
Directed evolution of hydrolases for prevention of G-type nerve agent intoxication
RD Gupta, M Goldsmith, Y Ashani, Y Simo, G Mullokandov, H Bar, ...
Nature Chemical Biology 7 (2), 120-125, 2011
1832011
Directed enzyme evolution: beyond the low-hanging fruit
M Goldsmith, DS Tawfik
Current opinion in structural biology 22 (4), 406-412, 2012
1652012
Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification
M Goldsmith, Y Ashani, Y Simo, M Ben-David, H Leader, I Silman, ...
Chemistry & biology 19 (4), 456-466, 2012
872012
Enzyme engineering by targeted libraries
M Goldsmith, DS Tawfik
Methods in enzymology 523, 257-283, 2013
832013
Potential role of phenotypic mutations in the evolution of protein expression and stability
M Goldsmith, DS Tawfik
Proceedings of the National Academy of Sciences 106 (15), 6197-6202, 2009
772009
Design and in vitro realization of carbon-conserving photorespiration
DL Trudeau, C Edlich-Muth, J Zarzycki, M Scheffen, M Goldsmith, ...
Proceedings of the National Academy of Sciences 115 (49), E11455-E11464, 2018
542018
Plasmid-encoded MucB protein is a DNA polymerase (pol RI) specialized for lesion bypass in the presence of MucA′, RecA, and SSB
M Goldsmith, L Sarov-Blat, Z Livneh
Proceedings of the National Academy of Sciences 97 (21), 11227-11231, 2000
542000
Automated design of efficient and functionally diverse enzyme repertoires
O Khersonsky, R Lipsh, Z Avizemer, Y Ashani, M Goldsmith, H Leader, ...
Molecular cell 72 (1), 178-186. e5, 2018
522018
Enzyme engineering: reaching the maximal catalytic efficiency peak
M Goldsmith, DS Tawfik
Current opinion in structural biology 47, 140-150, 2017
472017
Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro
F Worek, T Seeger, M Goldsmith, Y Ashani, H Leader, JS Sussman, ...
Archives of toxicology 88 (6), 1257-1266, 2014
472014
Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: a proof-of-concept study
F Worek, T Seeger, G Reiter, M Goldsmith, Y Ashani, H Leader, ...
Toxicology letters 231 (1), 45-54, 2014
412014
Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers
M Goldsmith, N Aggarwal, Y Ashani, H Jubran, PJ Greisen, S Ovchinnikov, ...
Protein Engineering, Design and Selection 30 (4), 333-345, 2017
382017
Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers
Y Ashani, RD Gupta, M Goldsmith, I Silman, JL Sussman, DS Tawfik, ...
Chemico-biological interactions 187 (1-3), 362-369, 2010
382010
Avoiding and controlling double transformation artifacts
M Goldsmith, C Kiss, ARM Bradbury, DS Tawfik
Protein Engineering, Design & Selection 20 (7), 315-318, 2007
372007
Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro
M Goldsmith, S Eckstein, Y Ashani, P Greisen, H Leader, JL Sussman, ...
Archives of toxicology 90 (11), 2711-2724, 2016
362016
Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection
T Wille, K Neumaier, M Koller, C Ehinger, N Aggarwal, Y Ashani, ...
Toxicology letters 258, 198-206, 2016
232016
Catalytic bioscavengers as countermeasures against organophosphate nerve agents
M Goldsmith, Y Ashani
Chemico-biological interactions 292, 50-64, 2018
212018
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