| Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo MR Hassler, AA Turanov, JF Alterman, RA Haraszti, AH Coles, MF Osborn, ... Nucleic acids research 46 (5), 2185-2196, 2018 | 148 | 2018 |
| Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo A Biscans, A Coles, R Haraszti, D Echeverria, M Hassler, M Osborn, ... Nucleic acids research 47 (3), 1082-1096, 2019 | 147 | 2019 |
| Hydrophobically modified siRNAs silence huntingtin mRNA in primary neurons and mouse brain JF Alterman, LM Hall, AH Coles, MR Hassler, MC Didiot, K Chase, ... Molecular Therapy-Nucleic Acids 4, 2015 | 146 | 2015 |
| RNA-Pt adducts following cisplatin treatment of Saccharomyces cerevisiae AA Hostetter, MF Osborn, VJ DeRose ACS Chemical Biology 7 (1), 218-225, 2011 | 114 | 2011 |
| Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways MF Osborn, AH Coles, A Biscans, RA Haraszti, L Roux, S Davis, S Ly, ... Nucleic acids research 47 (3), 1070-1081, 2019 | 112 | 2019 |
| Improving siRNA Delivery In Vivo Through Lipid Conjugation MF Osborn, A Khvorova Nucleic acid therapeutics 28 (3), 128-136, 2018 | 109 | 2018 |
| Docosahexaenoic acid conjugation enhances distribution and safety of siRNA upon local administration in mouse brain M Nikan, MF Osborn, AH Coles, BMDC Godinho, LM Hall, RA Haraszti, ... Molecular Therapy-Nucleic Acids 5, 2016 | 85 | 2016 |
| Excited state proton transfer in the red fluorescent protein mKeima JN Henderson, MF Osborn, N Koon, R Gepshtein, D Huppert, ... Journal of the American Chemical Society 131 (37), 13212-13213, 2009 | 81 | 2009 |
| Picazoplatin, an azide-containing platinum (II) derivative for target analysis by click chemistry JD White, MF Osborn, AD Moghaddam, LE Guzman, MM Haley, ... Journal of the American Chemical Society 135 (32), 11680-11683, 2013 | 65 | 2013 |
| Platinum-RNA modifications following drug treatment in S. cerevisiae identified by click chemistry and enzymatic mapping MF Osborn, JD White, MM Haley, VJ DeRose ACS Chemical Biology 9 (10), 2404-2411, 2014 | 64 | 2014 |
| Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs MF Osborn, JF Alterman, M Nikan, H Cao, MC Didiot, MR Hassler, ... Nucleic acids research 43 (18), 8664-8672, 2015 | 50 | 2015 |
| A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo AH Coles, MF Osborn, JF Alterman, AA Turanov, BMDC Godinho, ... Nucleic Acid Therapeutics, 2015 | 42 | 2015 |
| Novel cluster and monomer-based GalNAc structures induce effective uptake of siRNAs in vitro and in vivo VK Sharma, MF Osborn, MR Hassler, D Echeverria, S Ly, EA Ulashchik, ... Bioconjugate chemistry 29 (7), 2478-2488, 2018 | 37 | 2018 |
| Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in … M Nikan, MF Osborn, AH Coles, A Biscans, BMDC Godinho, RA Haraszti, ... Bioconjugate chemistry 28 (6), 1758-1766, 2017 | 36 | 2017 |
| Binding of kinetically inert metal ions to RNA: the case of platinum (II) EG Chapman, AA Hostetter, MF Osborn, AL Miller, VJ DeRose Metal Ions in Life Sciences 9, 347, 2011 | 24 | 2011 |
| Efficient gene silencing in brain tumors with hydrophobically modified siRNAs MF Osborn, AH Coles, D Golebiowski, D Echeverria, MP Moazami, ... Molecular cancer therapeutics 17 (6), 1251-1258, 2018 | 22 | 2018 |
| Taking charge of siRNA delivery A Khvorova, MF Osborn, MR Hassler Nature Biotechnology 32 (12), 1197-1198, 2014 | 20 | 2014 |
| Bioactive conjugates for oligonucleotide delivery A Khvorova, M Nikan, M Hassler, M Osborn, R Haraszti, A Coles, ... US Patent 10,633,653, 2020 | 16 | 2020 |
| Bioactive conjugates for oligonucleotide delivery A Khvorova, M Nikan, M Hassler, M Osborn, R Haraszti, A Coles, ... US Patent App. 16/812,714, 2020 | 4 | 2020 |
| Compositions and methods for inhibiting gene expression in the central nervous system BD Brown, M Osborn, W Wang | 1 | 2022 |
