| Cell-programmed nutrient partitioning in the tumour microenvironment BI Reinfeld, MZ Madden, MM Wolf, A Chytil, JE Bader, AR Patterson, ... Nature 593 (7858), 282-288, 2021 | 572 | 2021 |
| Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers JR Mayers, ME Torrence, LV Danai, T Papagiannakopoulos, ... Science 353 (6304), 1161-1165, 2016 | 529 | 2016 |
| Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability MR Sullivan, LV Danai, CA Lewis, SH Chan, DY Gui, T Kunchok, ... Elife 8, e44235, 2019 | 394 | 2019 |
| Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability MR Sullivan, LV Danai, CA Lewis, SH Chan, DY Gui, T Kunchok, ... Elife 8, e44235, 2019 | 394 | 2019 |
| Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae FM Roelants, DK Breslow, A Muir, JS Weissman, J Thorner Proceedings of the National Academy of Sciences 108 (48), 19222-19227, 2011 | 306 | 2011 |
| Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition A Muir, LV Danai, DY Gui, CY Waingarten, CA Lewis, MG Vander Heiden Elife 6, e27713, 2017 | 269 | 2017 |
| Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition A Muir, LV Danai, DY Gui, CY Waingarten, CA Lewis, MG Vander Heiden Elife 6, e27713, 2017 | 269 | 2017 |
| Increased serine synthesis provides an advantage for tumors arising in tissues where serine levels are limiting MR Sullivan, KR Mattaini, EA Dennstedt, AA Nguyen, S Sivanand, ... Cell metabolism 29 (6), 1410-1421. e4, 2019 | 202 | 2019 |
| Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer VI Sayin, SE LeBoeuf, SX Singh, SM Davidson, D Biancur, BS Guzelhan, ... Elife 6, e28083, 2017 | 190 | 2017 |
| TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids A Muir, S Ramachandran, FM Roelants, G Timmons, J Thorner Elife 3, e03779, 2014 | 165 | 2014 |
| Altered exocrine function can drive adipose wasting in early pancreatic cancer LV Danai, A Babic, MH Rosenthal, EA Dennstedt, A Muir, EC Lien, ... Nature 558 (7711), 600-604, 2018 | 126 | 2018 |
| Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies A Muir, LV Danai, MG Vander Heiden Disease models & mechanisms 11 (8), dmm035758, 2018 | 118 | 2018 |
| The nutrient environment affects therapy A Muir, MG Vander Heiden Science 360 (6392), 962-963, 2018 | 115 | 2018 |
| The NetrinG1/NGL-1 Axis promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression R Francescone, DB Vendramini-Costa, J Franco-Barraza, J Wagner, ... bioRxiv, 330209, 2019 | 110* | 2019 |
| Preprint highlights, selected by the biological community MR Sullivan, LV Danai, CA Lewis, SH Chan, DY Gui, T Kunchok, ... | 72* | |
| Down-regulation of TORC2-Ypk1 signaling promotes MAPK-independent survival under hyperosmotic stress A Muir, FM Roelants, G Timmons, KL Leskoske, J Thorner Elife 4, e09336, 2015 | 55 | 2015 |
| Sphingolipid biosynthesis upregulation by TOR complex 2–Ypk1 signaling during yeast adaptive response to acetic acid stress JF Guerreiro, A Muir, S Ramachandran, J Thorner, I Sá-Correia Biochemical Journal 473 (23), 4311-4325, 2016 | 51 | 2016 |
| Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1 R Romero, FJ Sánchez-Rivera, PMK Westcott, KL Mercer, A Bhutkar, ... Nature cancer 1 (6), 589-602, 2020 | 46 | 2020 |
| TOR complex 2-regulated protein kinase Fpk1 stimulates endocytosis via inhibition of Ark1/Prk1-related protein kinase Akl1 in Saccharomyces cerevisiae FM Roelants, KL Leskoske, RTA Pedersen, A Muir, JMH Liu, GC Finnigan, ... Molecular and cellular biology 37 (7), e00627-16, 2017 | 39 | 2017 |
| TOR complex 2–regulated protein kinase Ypk1 controls sterol distribution by inhibiting StARkin domain–containing proteins located at plasma membrane–endoplasmic reticulum … FM Roelants, N Chauhan, A Muir, JC Davis, AK Menon, TP Levine, ... Molecular biology of the cell 29 (17), 2128-2136, 2018 | 31 | 2018 |
Caroline A. (Lewis) ChidleyUMass Chan Medical SchoolVerified email at umassmed.edu
