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Alex Rizzo
Alex Rizzo
Principal Scientist, Orogen Therapeutics
Verified email at orogentx.com
Title
Cited by
Cited by
Year
Interaction between the Rev1 C-terminal domain and the PolD3 subunit of Polζ suggests a mechanism of polymerase exchange upon Rev1/Polζ-dependent translesion synthesis
Y Pustovalova, MTQ Magalhães, S D’Souza, AA Rizzo, G Korza, ...
Biochemistry 55 (13), 2043-2053, 2016
722016
Identification of small molecule translesion synthesis inhibitors that target the Rev1-CT/RIR protein− protein interaction
V Sail, AA Rizzo, N Chatterjee, RC Dash, Z Ozen, GC Walker, ...
ACS chemical biology 12 (7), 1903-1912, 2017
562017
Rev7 dimerization is important for assembly and function of the Rev1/Polζ translesion synthesis complex
AA Rizzo, FM Vassel, N Chatterjee, S D’Souza, Y Li, B Hao, MT Hemann, ...
Proceedings of the National Academy of Sciences 115 (35), E8191-E8200, 2018
552018
Multiple functional roles of the accessory I-domain of bacteriophage P22 coat protein revealed by NMR structure and CryoEM modeling
AA Rizzo, MM Suhanovsky, ML Baker, LTCR Fraser, LM Jones, ...
Structure 22 (6), 830-841, 2014
452014
NMR structure of the human Rad18 zinc finger in complex with ubiquitin defines a class of UBZ domains in proteins linked to the DNA damage response
AA Rizzo, PE Salerno, I Bezsonova, DM Korzhnev
Biochemistry 53 (37), 5895-5906, 2014
342014
The Rev1-Polζ translesion synthesis mutasome: Structure, interactions and inhibition
AA Rizzo, DM Korzhnev
The Enzymes 45, 139-181, 2019
252019
Structural approach to identify a lead scaffold that targets the translesion synthesis polymerase Rev1
RC Dash, Z Ozen, AA Rizzo, S Lim, DM Korzhnev, MK Hadden
Journal of Chemical Information and Modeling 58 (11), 2266-2277, 2018
182018
Virtual Pharmacophore Screening Identifies Small‐Molecule Inhibitors of the Rev1‐CT/RIR Protein–Protein Interaction
RC Dash, Z Ozen, KR McCarthy, N Chatterjee, CA Harris, AA Rizzo, ...
ChemMedChem 14 (17), 1610-1617, 2019
162019
Dynamics of the E. coli β-clamp dimer interface and its influence on DNA loading
BN Koleva, H Gokcan, AA Rizzo, S Lim, KJD Fouque, A Choy, ML Liriano, ...
Biophysical Journal 117 (3), 587-601, 2019
122019
Small molecule scaffolds that disrupt the Rev1-CT/RIR protein-protein interaction
Z Ozen, RC Dash, KR McCarthy, SA Chow, AA Rizzo, DM Korzhnev, ...
Bioorganic & Medicinal Chemistry 26 (14), 4301-4309, 2018
122018
NMR assignments for the telokin-like domain of bacteriophage P22 coat protein
AA Rizzo, LTCR Fraser, SR Sheftic, MM Suhanovsky, CM Teschke, ...
Biomolecular NMR assignments 7, 257-260, 2013
112013
Structure‐Based Drug Design of Phenazopyridine Derivatives as Inhibitors of Rev1 Interactions in Translesion Synthesis
KS McPherson, AM Zaino, RC Dash, AA Rizzo, Y Li, B Hao, I Bezsonova, ...
ChemMedChem 16 (7), 1126-1132, 2021
72021
Evolution of Rev7 interactions in eukaryotic TLS DNA polymerase Polζ
KS McPherson, AA Rizzo, H Erlandsen, N Chatterjee, GC Walker, ...
Journal of Biological Chemistry 299 (2), 2023
12023
NMR resonance assignments for the N-terminal domain of the δ subunit of the E. coli γ clamp loader complex
EM Alyami, AA Rizzo, PJ Beuning, DM Korzhnev
Biomolecular NMR Assignments 11, 169-173, 2017
12017
Assembly and Inhibition of the Rev1/Polz Mutasome
AA Rizzo
2019
NMR Assignments and Structure of the I-domain from the Bacteriophage P22 Coat Protein
AA Rizzo
2013
Second-line drugs in the treatment of resistant forms of pulmonary tuberculosis.
A Rizzo, N Moura, M Magalhães, G Antunes, C Campelo
Revista Brasileira de Medicina 23 (12), 850-52, 1966
1966
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Articles 1–17