Frederic Sigoillot
Frederic Sigoillot
Novartis - NIBR - Chemical Biology and Therapeutics - Data Science
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A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response
B Adamson, A Smogorzewska, FD Sigoillot, RW King, SJ Elledge
Nature cell biology 14 (3), 318-328, 2012
Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage
X Zeng, F Sigoillot, S Gaur, S Choi, KL Pfaff, DC Oh, N Hathaway, ...
Cancer cell 18 (4), 382-395, 2010
Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C
KL Sackton, N Dimova, X Zeng, W Tian, M Zhang, TB Sackton, J Meaders, ...
Nature 514 (7524), 646-649, 2014
A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens
FD Sigoillot, S Lyman, JF Huckins, B Adamson, E Chung, B Quattrochi, ...
Nature methods 9 (4), 363-366, 2012
YAP, but not RSPO-LGR4/5, signaling in biliary epithelial cells promotes a ductular reaction in response to liver injury
L Planas-Paz, T Sun, M Pikiolek, NR Cochran, S Bergling, V Orsini, ...
Cell stem cell 25 (1), 39-53. e10, 2019
Vigilance and validation: Keys to success in RNAi screening
FD Sigoillot, RW King
ACS chemical biology 6 (1), 47-60, 2011
Cell cycle-dependent regulation of pyrimidine biosynthesis
FD Sigoillot, JA Berkowski, SM Sigoillot, DH Kotsis, HI Guy
Journal of Biological Chemistry 278 (5), 3403-3409, 2003
USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin
L Ji, B Lu, R Zamponi, O Charlat, R Aversa, Z Yang, F Sigoillot, X Zhu, ...
Nature Communications 10 (1), 4184, 2019
Growth-dependent regulation of mammalian pyrimidine biosynthesis by the protein kinase A and MAPK signaling cascades
FD Sigoillot, DR Evans, HI Guy
Journal of Biological Chemistry 277 (18), 15745-15751, 2002
CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma
NT Ross, F Lohmann, S Carbonneau, A Fazal, WA Weihofen, S Gleim, ...
Nature chemical biology 16 (1), 50-59, 2020
Discovery of a ZIP7 inhibitor from a Notch pathway screen
E Nolin, S Gans, L Llamas, S Bandyopadhyay, SM Brittain, ...
Nature chemical biology 15 (2), 179-188, 2019
The G2/M Regulator Histone Demethylase PHF8 Is Targeted for Degradation by the Anaphase-Promoting Complex Containing CDC20
HJ Lim, NV Dimova, MKM Tan, FD Sigoillot, RW King, Y Shi
Molecular and cellular biology 33 (21), 4166-4180, 2013
Breakdown of the regulatory control of pyrimidine biosynthesis in human breast cancer cells
FD Sigoillot, SM Sigoillot, HI Guy
International journal of cancer 109 (4), 491-498, 2004
Hyperactivation of MAPK signaling is deleterious to RAS/RAF-mutant melanoma
GP Leung, T Feng, FD Sigoillot, FC Geyer, MD Shirley, DA Ruddy, ...
Molecular Cancer Research 17 (1), 199-211, 2019
Nuclear Localization and Mitogen-Activated Protein Kinase Phosphorylationof the Multifunctional ProteinCAD
FD Sigoillot, DH Kotsis, V Serre, SM Sigoillot, DR Evans, HI Guy
Journal of Biological Chemistry 280 (27), 25611-25620, 2005
Online GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis
B Yilmazel, Y Hu, F Sigoillot, JA Smith, CE Shamu, N Perrimon, SE Mohr
BMC bioinformatics 15 (1), 1-6, 2014
A genome-wide CRISPR screen identifies ZCCHC14 as a host factor required for hepatitis B surface antigen production
A Hyrina, C Jones, D Chen, S Clarkson, N Cochran, P Feucht, G Hoffman, ...
Cell Reports 29 (10), 2970-2978. e6, 2019
Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC
H Zeng, J Castillo-Cabrera, M Manser, B Lu, Z Yang, V Strande, D Begue, ...
Elife 8, e50223, 2019
MiR-210 promotes sensory hair cell formation in the organ of corti
S Riccardi, S Bergling, F Sigoillot, M Beibel, A Werner, J Leighton-Davies, ...
BMC genomics 17 (1), 1-14, 2016
Recurrent ubiquitin B silencing in gynecological cancers establishes dependence on ubiquitin C
AT Kedves, S Gleim, X Liang, DM Bonal, F Sigoillot, F Harbinski, ...
The Journal of Clinical Investigation 127 (12), 4554-4568, 2017
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