Clement T. Y. Chan
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Antibiotics induce redox-related physiological alterations as part of their lethality
DJ Dwyer, PA Belenky, JH Yang, IC MacDonald, JD Martell, N Takahashi, ...
Proceedings of the National Academy of Sciences 111 (20), E2100-E2109, 2014
A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress
CTY Chan, M Dyavaiah, MS DeMott, K Taghizadeh, PC Dedon, TJ Begley
PLoS Genetics 6 (12), e1001247, 2010
Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins
CTY Chan, YLJ Pang, W Deng, IR Babu, M Dyavaiah, TJ Begley, ...
Nature communications 3 (1), 1-9, 2012
'Deadman'and'Passcode'microbial kill switches for bacterial containment
CTY Chan, JW Lee, DE Cameron, CJ Bashor, JJ Collins
Nature chemical biology 12 (2), 82-86, 2016
Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival
D Fu, JAN Brophy, CTY Chan, KA Atmore, U Begley, RS Paules, ...
Molecular and cellular biology 30 (10), 2449-2459, 2010
Site-Specific Insertion of 3-Aminotyrosine into Subunit α2 of E. coli Ribonucleotide Reductase:  Direct Evidence for Involvement of Y730 and Y731 in Radical …
MR Seyedsayamdost, J Xie, CTY Chan, PG Schultz, JA Stubbe
Journal of the American Chemical Society 129 (48), 15060-15071, 2007
Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry
D Su, CTY Chan, C Gu, KS Lim, YH Chionh, ME McBee, BS Russell, ...
Nature protocols 9 (4), 828-841, 2014
Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications
A Patil, C Chan, M Dyavaiah, J Rooney, P Dedon, T Begley
RNA biology 9 (7), 2012
Next-generation biocontainment systems for engineered organisms
JW Lee, CTY Chan, S Slomovic, JJ Collins
Nature chemical biology, 1, 2018
A human tRNA methyltransferase 9‐like protein prevents tumour growth by regulating LIN9 and HIF1‐α
U Begley, MS Sosa, A Avivar‐Valderas, A Patil, L Endres, Y Estrada, ...
EMBO molecular medicine 5 (3), 366-383, 2013
Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response
A Patil, M Dyavaiah, F Joseph, JP Rooney, CTY Chan, PC Dedon, ...
Cell cycle 11 (19), 3656-3665, 2012
PELDOR spectroscopy with DOPA-β2 and NH2Y-α2s: distance measurements between residues involved in the radical propagation pathway of E. coli ribonucleotide reductase
MR Seyedsayamdost, CTY Chan, V Mugnaini, JA Stubbe, M Bennati
Journal of the American Chemical Society 129 (51), 15748-15749, 2007
Highly predictive reprogramming of tRNA modifications is linked to selective expression of codon-biased genes
CTY Chan, W Deng, F Li, MS DeMott, IR Babu, TJ Begley, PC Dedon
Chemical research in toxicology 28 (5), 978-988, 2015
Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs
D Mandal, C Köhrer, D Su, IR Babu, CTY Chan, Y Liu, D Söll, P Blum, ...
RNA 20 (2), 177-188, 2014
Identification of N6, N6-dimethyladenosine in transfer RNA from Mycobacterium bovis Bacille Calmette-Guerin
CTY Chan, YH Chionh, CH Ho, KS Lim, IR Babu, E Ang, L Wenwei, ...
Molecules 16 (6), 5168-5181, 2011
Engineering repressors with coevolutionary cues facilitates toggle switches with a master reset
RP Dimas, XL Jiang, J Alberto de la Paz, F Morcos, CTY Chan
Nucleic acids research 47 (10), 5449-5463, 2019
Engineering DNA recognition and allosteric response properties of TetR family proteins by using a module-swapping strategy
RP Dimas, BR Jordan, XL Jiang, C Martini, JS Glavy, DP Patterson, ...
Nucleic acids research 47 (16), 8913-8925, 2019
A Module Swapping Approach to Engineer Allosterically Regulated Transcriptional Regulators
CTY Chan
The FASEB Journal 34 (S1), 1-1, 2020
Antibiotics induce nitrosative stress in microorganisms
C Chan
Cell cycle regulation via gene-specific codon usage and increased tRNA modifications
A Patil, M Dyavaiah, F Joseph, JP Rooney, CT Chan, PC Dedon, ...
Rna Biology 9 (11), 1303, 2012
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