BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells ED Lagadinou, A Sach, K Callahan, RM Rossi, SJ Neering, ... Cell stem cell 12 (3), 329-341, 2013 | 1213 | 2013 |
Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia DA Pollyea, BM Stevens, CL Jones, A Winters, S Pei, M Minhajuddin, ... Nature medicine 24 (12), 1859-1866, 2018 | 574 | 2018 |
Leukemic stem cells evade chemotherapy by metabolic adaptation to an adipose tissue niche H Ye, B Adane, N Khan, T Sullivan, M Minhajuddin, M Gasparetto, ... Cell stem cell 19 (1), 23-37, 2016 | 468 | 2016 |
Inhibition of amino acid metabolism selectively targets human leukemia stem cells CL Jones, BM Stevens, A D'Alessandro, JA Reisz, R Culp-Hill, T Nemkov, ... Cancer cell 34 (5), 724-740. e4, 2018 | 442 | 2018 |
Monocytic subclones confer resistance to venetoclax-based therapy in patients with acute myeloid leukemia S Pei, DA Pollyea, A Gustafson, BM Stevens, M Minhajuddin, R Fu, ... Cancer discovery 10 (4), 536-551, 2020 | 295 | 2020 |
AMPK/FIS1-mediated mitophagy is required for self-renewal of human AML stem cells S Pei, M Minhajuddin, B Adane, N Khan, BM Stevens, SC Mack, S Lai, ... Cell stem cell 23 (1), 86-100. e6, 2018 | 220 | 2018 |
Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells S Pei, M Minhajuddin, KP Callahan, M Balys, JM Ashton, SJ Neering, ... Journal of Biological Chemistry 288 (47), 33542-33558, 2013 | 213 | 2013 |
The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation HA Zahreddine, B Culjkovic-Kraljacic, S Assouline, P Gendron, ... Nature 511 (7507), 90-93, 2014 | 199 | 2014 |
Fatty acid metabolism underlies venetoclax resistance in acute myeloid leukemia stem cells BM Stevens, CL Jones, DA Pollyea, R Culp-Hill, A D’Alessandro, ... Nature cancer 1 (12), 1176-1187, 2020 | 173 | 2020 |
Nicotinamide metabolism mediates resistance to venetoclax in relapsed acute myeloid leukemia stem cells CL Jones, BM Stevens, DA Pollyea, R Culp-Hill, JA Reisz, T Nemkov, ... Cell stem cell 27 (5), 748-764. e4, 2020 | 153 | 2020 |
Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II CL Jones, BM Stevens, A D’Alessandro, R Culp-Hill, JA Reisz, S Pei, ... Blood, The Journal of the American Society of Hematology 134 (4), 389-394, 2019 | 126 | 2019 |
Venetoclax and azacitidine compared with induction chemotherapy for newly diagnosed patients with acute myeloid leukemia EM Cherry, D Abbott, M Amaya, C McMahon, M Schwartz, J Rosser, ... Blood advances 5 (24), 5565-5573, 2021 | 104 | 2021 |
The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability J Du, X Cai, J Yao, X Ding, Q Wu, S Pei, K Jiang, Y Zhang, W Wang, Y Shi, ... Oncogene 27 (29), 4107-4114, 2008 | 91 | 2008 |
The hematopoietic oxidase NOX2 regulates self-renewal of leukemic stem cells B Adane, H Ye, N Khan, S Pei, M Minhajuddin, BM Stevens, CL Jones, ... Cell reports 27 (1), 238-254. e6, 2019 | 73 | 2019 |
The STAT3-MYC axis promotes survival of leukemia stem cells by regulating SLC1A5 and oxidative phosphorylation ML Amaya, A Inguva, S Pei, C Jones, A Krug, H Ye, M Minhajuddin, ... Blood, The Journal of the American Society of Hematology 139 (4), 584-596, 2022 | 61 | 2022 |
SomVarIUS: somatic variant identification from unpaired tissue samples KS Smith, VK Yadav, S Pei, DA Pollyea, CT Jordan, S De Bioinformatics 32 (6), 808-813, 2016 | 55 | 2016 |
Melampomagnolide B: a new antileukemic sesquiterpene S Nasim, SS Pei, FK Hagen, CT Jordan, PA Crooks Bioorganic & medicinal chemistry 19 (4), 1515-1519, 2011 | 49 | 2011 |
Inhibition of amino acid metabolism selectively targets human leukemia stem cells CL Jones, BM Stevens, A D’Alessandro, JA Reisz, R Culp-Hill, T Nemkov, ... Cancer Cell 35 (2), 333-335, 2019 | 47 | 2019 |
Rational design of a parthenolide-based drug regimen that selectively eradicates acute myelogenous leukemia stem cells S Pei, M Minhajuddin, A D'Alessandro, T Nemkov, BM Stevens, B Adane, ... Journal of Biological Chemistry 291 (42), 21984-22000, 2016 | 39 | 2016 |
Targeted therapy for a subset of acute myeloid leukemias that lack expression of aldehyde dehydrogenase 1A1 M Gasparetto, S Pei, M Minhajuddin, N Khan, DA Pollyea, JR Myers, ... Haematologica 102 (6), 1054, 2017 | 23 | 2017 |