| Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation P Flagmeier, G Meisl, M Vendruscolo, TPJ Knowles, CM Dobson, ... Proceedings of the National Academy of Sciences 113 (37), 10328-10333, 2016 | 309 | 2016 |
| A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ... Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017 | 307 | 2017 |
| Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein C Galvagnion, JWP Brown, MM Ouberai, P Flagmeier, M Vendruscolo, ... Proceedings of the National Academy of Sciences 113 (26), 7065-7070, 2016 | 302 | 2016 |
| Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, ... Nature communications 10 (1), 1541, 2019 | 174 | 2019 |
| Protein microgels from amyloid fibril networks U Shimanovich, I Efimov, TO Mason, P Flagmeier, AK Buell, A Gedanken, ... ACS nano 9 (1), 43-51, 2015 | 138 | 2015 |
| Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, ... ACS chemical biology 13 (8), 2308-2319, 2018 | 108 | 2018 |
| Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, ... Angewandte Chemie International Edition 56 (27), 7750-7754, 2017 | 102 | 2017 |
| Hsp70 inhibits the nucleation and elongation of tau and sequesters tau aggregates with high affinity F Kundel, S De, P Flagmeier, MH Horrocks, M Kjaergaard, SL Shammas, ... ACS chemical biology 13 (3), 636-646, 2018 | 98 | 2018 |
| Mapping surface hydrophobicity of α-synuclein oligomers at the nanoscale JE Lee, JC Sang, M Rodrigues, AR Carr, MH Horrocks, S De, ... Nano letters 18 (12), 7494-7501, 2018 | 96 | 2018 |
| β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces JWP Brown, AK Buell, TCT Michaels, G Meisl, J Carozza, P Flagmeier, ... Scientific reports 6 (1), 36010, 2016 | 94 | 2016 |
| An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils ED Agerschou, P Flagmeier, T Saridaki, C Galvagnion, D Komnig, L Heid, ... Elife 8, e46112, 2019 | 66 | 2019 |
| Single-molecule characterization of the interactions between extracellular chaperones and toxic α-synuclein oligomers DR Whiten, D Cox, MH Horrocks, CG Taylor, S De, P Flagmeier, L Tosatto, ... Cell reports 23 (12), 3492-3500, 2018 | 64 | 2018 |
| The influence of pathogenic mutations in α-synuclein on biophysical and structural characteristics of amyloid fibrils FS Ruggeri, P Flagmeier, JR Kumita, G Meisl, DY Chirgadze, ... ACS nano 14 (5), 5213-5222, 2020 | 63 | 2020 |
| Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates S Chia, P Flagmeier, J Habchi, V Lattanzi, S Linse, CM Dobson, ... Proceedings of the National Academy of Sciences 114 (30), 8005-8010, 2017 | 57 | 2017 |
| Nanoscopic characterisation of individual endogenous protein aggregates in human neuronal cells DR Whiten, Y Zuo, L Calo, ML Choi, S De, P Flagmeier, DC Wirthensohn, ... ChemBioChem 19 (19), 2033-2038, 2018 | 56 | 2018 |
| Quantifying co-oligomer formation by α-synuclein M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, ... ACS nano 12 (11), 10855-10866, 2018 | 53 | 2018 |
| Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation P Flagmeier, S De, TCT Michaels, X Yang, AJ Dear, C Emanuelsson, ... Nature Structural & Molecular Biology 27 (10), 886-891, 2020 | 49 | 2020 |
| Optical Structural Analysis of Individual α‐Synuclein Oligomers JA Varela, M Rodrigues, S De, P Flagmeier, S Gandhi, CM Dobson, ... Angewandte Chemie 130 (18), 4980-4984, 2018 | 43 | 2018 |
| Squalamine and its derivatives modulate the aggregation of amyloid-β and α-synuclein and suppress the toxicity of their oligomers R Limbocker, R Staats, S Chia, FS Ruggeri, B Mannini, CK Xu, M Perni, ... Frontiers in Neuroscience 15, 680026, 2021 | 40 | 2021 |
| Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation A Vilalta, Y Zhou, J Sevalle, JK Griffin, K Satoh, DH Allendorf, S De, ... Journal of Biological Chemistry 296, 2021 | 35 | 2021 |
Christopher DobsonUniversity of Cambridgeכתובת אימייל מאומתת בדומיין cam.ac.uk
