| Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial RE MacLaren, M Groppe, AR Barnard, CL Cottriall, T Tolmachova, ... The Lancet 383 (9923), 1129-1137, 2014 | 880 | 2014 |
| Exosome-delivered microRNAs modulate the inflammatory response to endotoxin M Alexander, R Hu, MC Runtsch, DA Kagele, TL Mosbruger, ... Nature communications 6 (1), 7321, 2015 | 737 | 2015 |
| MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells IS Okoye, SM Coomes, VS Pelly, S Czieso, V Papayannopoulos, ... Immunity 41 (1), 89-103, 2014 | 598 | 2014 |
| Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes C Jancic, A Savina, C Wasmeier, T Tolmachova, J El-Benna, PMC Dang, ... Nature cell biology 9 (4), 367-378, 2007 | 286 | 2007 |
| Visual acuity after retinal gene therapy for choroideremia TL Edwards, JK Jolly, M Groppe, AR Barnard, CL Cottriall, T Tolmachova, ... New England Journal of Medicine 374 (20), 1996-1998, 2016 | 224 | 2016 |
| Rab27b regulates number and secretion of platelet dense granules T Tolmachova, M Åbrink, CE Futter, KS Authi, MC Seabra Proceedings of the National Academy of Sciences 104 (14), 5872-5877, 2007 | 203 | 2007 |
| Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome DC Barral, JS Ramalho, R Anders, AN Hume, HJ Knapton, T Tolmachova, ... The Journal of clinical investigation 110 (2), 247-257, 2002 | 194 | 2002 |
| Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia K Xue, JK Jolly, AR Barnard, A Rudenko, AP Salvetti, MI Patrício, ... Nature medicine 24 (10), 1507-1512, 2018 | 176 | 2018 |
| A general role for Rab27a in secretory cells T Tolmachova, R Anders, J Stinchcombe, G Bossi, GM Griffiths, C Huxley, ... Molecular biology of the cell 15 (1), 332-344, 2004 | 176 | 2004 |
| Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia T Tolmachova, R Anders, M Abrink, L Bugeon, MJ Dallman, CE Futter, ... The Journal of clinical investigation 116 (2), 386-394, 2006 | 129 | 2006 |
| Induced myelination and demyelination in a conditional mouse model of Charcot–Marie–Tooth disease type 1A J Perea, A Robertson, T Tolmachova, J Muddle, RHM King, S Ponsford, ... Human molecular genetics 10 (10), 1007-1018, 2001 | 128 | 2001 |
| Rab27b regulates mast cell granule dynamics and secretion K Mizuno, T Tolmachova, DS Ushakov, M Romao, M Åbrink, MA Ferenczi, ... Traffic 8 (7), 883-892, 2007 | 120 | 2007 |
| Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms JL Johnson, AA Brzezinska, T Tolmachova, DB Munafo, BA Ellis, ... Traffic 11 (4), 533-547, 2010 | 109 | 2010 |
| Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo T Tolmachova, OE Tolmachov, AR Barnard, SR de Silva, DM Lipinski, ... Journal of molecular medicine 91, 825-837, 2013 | 98 | 2013 |
| Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics EM Storck, J Morales-Sanfrutos, RA Serwa, N Panyain, T Lanyon-Hogg, ... Nature Chemistry 11 (6), 552-561, 2019 | 95 | 2019 |
| Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type–specific knockout mouse models of choroideremia T Tolmachova, ST Wavre-Shapton, AR Barnard, RE MacLaren, CE Futter, ... Investigative ophthalmology & visual science 51 (10), 4913-4920, 2010 | 94 | 2010 |
| Rab27-dependent exosome production inhibits chronic inflammation and enables acute responses to inflammatory stimuli M Alexander, AG Ramstead, KM Bauer, SH Lee, MC Runtsch, J Wallace, ... The Journal of Immunology 199 (10), 3559-3570, 2017 | 84 | 2017 |
| Distinct and opposing roles for R ab27a/M lph/M yo V a and R ab27b/M unc13‐4 in mast cell secretion RK Singh, K Mizuno, C Wasmeier, ST Wavre‐Shapton, C Recchi, SD Catz, ... The FEBS journal 280 (3), 892-903, 2013 | 84 | 2013 |
| PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils KE Anderson, TAM Chessa, K Davidson, RB Henderson, S Walker, ... Blood, The Journal of the American Society of Hematology 116 (23), 4978-4989, 2010 | 69 | 2010 |
| Conditional ablation of the choroideremia gene causes age-related changes in mouse retinal pigment epithelium ST Wavre-Shapton, T Tolmachova, ML da Silva, CE Futter, MC Seabra PloS one 8 (2), e57769, 2013 | 67 | 2013 |
