Hans Clevers
Hans Clevers
Verified email at hubrecht.eu - Homepage
Cited by
Cited by
Wnt/β-catenin signaling in development and disease
H Clevers
Cell 127 (3), 469-480, 2006
Identification of stem cells in small intestine and colon by marker gene Lgr5
N Barker, JH Van Es, J Kuipers, P Kujala, M Van Den Born, M Cozijnsen, ...
Nature 449 (7165), 1003-1007, 2007
Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
PJ Morin, AB Sparks, V Korinek, N Barker, H Clevers, B Vogelstein, ...
Science 275 (5307), 1787-1790, 1997
Wnt/β-catenin signaling and disease
H Clevers, R Nusse
Cell 149 (6), 1192-1205, 2012
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
T Sato, RG Vries, HJ Snippert, M Van De Wetering, N Barker, DE Stange, ...
Nature 459 (7244), 262-265, 2009
Wnt signalling in stem cells and cancer
T Reya, H Clevers
Nature 434 (7035), 843-850, 2005
Constitutive transcriptional activation by a β-catenin-Tcf complex in APC−/− colon carcinoma
V Korinek, N Barker, PJ Morin, D Van Wichen, R De Weger, KW Kinzler, ...
Science 275 (5307), 1784-1787, 1997
The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
M Van De Wetering, E Sancho, C Verweij, W De Lau, I Oving, A Hurlstone, ...
Cell 111 (2), 241-250, 2002
XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos
M Molenaar, M Van De Wetering, M Oosterwegel, J Peterson-Maduro, ...
Cell 86 (3), 391-399, 1996
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium
T Sato, DE Stange, M Ferrante, RGJ Vries, JH Van Es, S Van Den Brink, ...
Gastroenterology 141 (5), 1762-1772, 2011
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
T Sato, JH Van Es, HJ Snippert, DE Stange, RG Vries, M Van Den Born, ...
Nature 469 (7330), 415-418, 2011
Crypt stem cells as the cells-of-origin of intestinal cancer
N Barker, RA Ridgway, JH Van Es, M Van De Wetering, H Begthel, ...
Nature 457 (7229), 608-611, 2009
Wnt/β-catenin signaling, disease, and emerging therapeutic modalities
R Nusse, H Clevers
Cell 169 (6), 985-999, 2017
The cancer stem cell: premises, promises and challenges
H Clevers
Nature medicine 17 (3), 313-319, 2011
Caught up in a Wnt storm: Wnt signaling in cancer
RH Giles, JH Van Es, H Clevers
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1653 (1), 1-24, 2003
Linking colorectal cancer to Wnt signaling
M Bienz, H Clevers
Cell 103 (2), 311-320, 2000
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
V Korinek, N Barker, P Moerer, E van Donselaar, G Huls, PJ Peters, ...
Nature genetics 19 (4), 379-383, 1998
Stem cells, self-renewal, and differentiation in the intestinal epithelium
LG Van Der Flier, H Clevers
Annual review of physiology 71, 241-260, 2009
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
JH van Es, ME Van Gijn, O Riccio, M Van Den Born, M Vooijs, H Begthel, ...
Nature 435 (7044), 959-963, 2005
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells
HJ Snippert, LG Van Der Flier, T Sato, JH Van Es, M Van Den Born, ...
Cell 143 (1), 134-144, 2010
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