Joseph W. Lewcock
Joseph W. Lewcock
CSO and Head of Discovery, Denali Therapeutics
Verified email at
Cited by
Cited by
TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge
AA Nugent, K Lin, B Van Lengerich, S Lianoglou, L Przybyla, SS Davis, ...
Neuron 105 (5), 837-854. e9, 2020
A feedback mechanism regulates monoallelic odorant receptor expression
JW Lewcock, RR Reed
Proceedings of the National Academy of Sciences 101 (4), 1069-1074, 2004
DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury
TA Watkins, B Wang, S Huntwork-Rodriguez, J Yang, Z Jiang, ...
Proceedings of the National Academy of Sciences 110 (10), 4039-4044, 2013
The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics
JW Lewcock, N Genoud, K Lettieri, SL Pfaff
Neuron 56 (4), 604-620, 2007
DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity
A Sengupta Ghosh, B Wang, CD Pozniak, M Chen, RJ Watts, JW Lewcock
Journal of Cell Biology 194 (5), 751-764, 2011
Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region
K Schlepckow, KM Monroe, G Kleinberger, L Cantuti‐Castelvetri, ...
EMBO molecular medicine 12 (4), e11227, 2020
Small-molecule modulation of TDP-43 recruitment to stress granules prevents persistent TDP-43 accumulation in ALS/FTD
MY Fang, S Markmiller, AQ Vu, A Javaherian, WE Dowdle, P Jolivet, ...
Neuron 103 (5), 802-819. e11, 2019
Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits
CP Myers, JW Lewcock, MG Hanson, S Gosgnach, JB Aimone, FH Gage, ...
Neuron 46 (1), 37-49, 2005
Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia
BJ Andreone, L Przybyla, C Llapashtica, A Rana, SS Davis, ...
Nature Neuroscience 23 (8), 927-938, 2020
Emerging microglia biology defines novel therapeutic approaches for Alzheimer’s disease
JW Lewcock, K Schlepckow, G Di Paolo, S Tahirovic, KM Monroe, ...
Neuron 108 (5), 801-821, 2020
Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory receptor neuron projection
SS Wang, JW Lewcock, P Feinstein, P Mombaerts, RR Reed
Oxford University Press for The Company of Biologists Limited 131 (6), 1377-1388, 2004
JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis
S Huntwork-Rodriguez, B Wang, T Watkins, AS Ghosh, CD Pozniak, ...
Journal of Cell Biology 202 (5), 747-763, 2013
Presenilin-dependent receptor processing is required for axon guidance
G Bai, O Chivatakarn, D Bonanomi, K Lettieri, L Franco, C Xia, E Stein, ...
Cell 144 (1), 106-118, 2011
FGF as a target-derived chemoattractant for developing motor axons genetically programmed by the LIM code
R Shirasaki, JW Lewcock, K Lettieri, SL Pfaff
Neuron 50 (6), 841-853, 2006
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease
CE Le Pichon, WJ Meilandt, S Dominguez, H Solanoy, H Lin, H Ngu, ...
Science translational medicine 9 (403), eaag0394, 2017
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic
T Logan, MJ Simon, A Rana, GM Cherf, A Srivastava, SS Davis, RLY Low, ...
Cell 184 (18), 4651-4668. e25, 2021
Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration
CD Pozniak, A Sengupta Ghosh, A Gogineni, JE Hanson, SH Lee, ...
Journal of Experimental Medicine 210 (12), 2553-2567, 2013
Leveraging preclinical models for the development of Alzheimer disease therapeutics
K Scearce-Levie, PE Sanchez, JW Lewcock
Nature Reviews Drug Discovery 19 (7), 447-462, 2020
The Ste20 family kinases MAP4K4, MINK1, and TNIK converge to regulate stress-induced JNK signaling in neurons
M Larhammar, S Huntwork-Rodriguez, Y Rudhard, A Sengupta-Ghosh, ...
Journal of Neuroscience 37 (46), 11074-11084, 2017
Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models
S Patel, F Cohen, BJ Dean, K De La Torre, G Deshmukh, AA Estrada, ...
Journal of medicinal chemistry 58 (1), 401-418, 2015
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