Ophir Shalem
Ophir Shalem
University of Pennsylvania / Children's Hospital of Philadelphia
Verified email at
Cited by
Cited by
Genome-scale CRISPR-Cas9 knockout screening in human cells
O Shalem, NE Sanjana, E Hartenian, X Shi, DA Scott, TS Mikkelsen, ...
Science 343 (6166), 84-87, 2014
DNA targeting specificity of RNA-guided Cas9 nucleases
PD Hsu, DA Scott, JA Weinstein, FA Ran, S Konermann, V Agarwala, Y Li, ...
Nature biotechnology 31 (9), 827-832, 2013
Improved vectors and genome-wide libraries for CRISPR screening
NE Sanjana, O Shalem, F Zhang
Nature methods 11 (8), 783-784, 2014
In vivo genome editing using Staphylococcus aureus Cas9
FA Ran, L Cong, WX Yan, DA Scott, JS Gootenberg, AJ Kriz, B Zetsche, ...
Nature 520 (7546), 186-191, 2015
High-throughput functional genomics using CRISPR–Cas9
O Shalem, NE Sanjana, F Zhang
Nature Reviews Genetics 16 (5), 299-311, 2015
Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis
S Chen, NE Sanjana, K Zheng, O Shalem, K Lee, X Shi, DA Scott, J Song, ...
Cell 160 (6), 1246-1260, 2015
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
MC Canver, EC Smith, F Sher, L Pinello, NE Sanjana, O Shalem, ...
Nature 527 (7577), 192-197, 2015
A genome-wide CRISPR screen in primary immune cells to dissect regulatory networks
O Parnas, M Jovanovic, TM Eisenhaure, RH Herbst, A Dixit, CJ Ye, ...
Cell 162 (3), 675-686, 2015
Hypoxia as a therapy for mitochondrial disease
IH Jain, L Zazzeron, R Goli, K Alexa, S Schatzman-Bone, H Dhillon, ...
Science 352 (6281), 54-61, 2016
Axonal transcription factors signal retrogradely in lesioned peripheral nerve
K Ben‐Yaakov, SY Dagan, Y Segal‐Ruder, O Shalem, D Vuppalanchi, ...
The EMBO journal 31 (6), 1350-1363, 2012
High-resolution interrogation of functional elements in the noncoding genome
ZF Sanjana NE, Wright J, Zheng K, Shalem O, Fontanillas P, Joung J, Cheng C ...
Science 353 (6307), 1545-1549, 2016
Transient transcriptional responses to stress are generated by opposing effects of mRNA production and degradation
O Shalem, O Dahan, M Levo, MR Martinez, I Furman, E Segal, Y Pilpel
Molecular systems biology 4 (1), 4, 2008
Signaling to transcription networks in the neuronal retrograde injury response
I Michaelevski, Y Segal-Ruder, M Rozenbaum, KF Medzihradszky, ...
Science signaling 3 (130), ra53-ra53, 2010
Transcriptome kinetics is governed by a genome-wide coupling of mRNA production and degradation: a role for RNA Pol II
O Shalem, B Groisman, M Choder, O Dahan, Y Pilpel
PLoS genetics 7 (9), e1002273, 2011
Systematic dissection of the sequence determinants of gene 3’end mediated expression control
O Shalem, E Sharon, S Lubliner, I Regev, M Lotan-Pompan, Z Yakhini, ...
PLoS genetics 11 (4), e1005147, 2015
Widespread promoter-mediated coordination of transcription and mRNA degradation
M Dori-Bachash, O Shalem, YS Manor, Y Pilpel, I Tirosh
Genome biology 13, 1-14, 2012
Measurements of the impact of 3′ end sequences on gene expression reveal wide range and sequence dependent effects
O Shalem, L Carey, D Zeevi, E Sharon, L Keren, A Weinberger, O Dahan, ...
PLoS computational biology 9 (3), e1002934, 2013
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