| The prostanoid EP4 receptor and its signaling pathway U Yokoyama, K Iwatsubo, M Umemura, T Fujita, Y Ishikawa Pharmacological reviews 65 (3), 1010-1052, 2013 | 282 | 2013 |
| Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus U Yokoyama, S Minamisawa, H Quan, S Ghatak, T Akaike, ... The Journal of clinical investigation 116 (11), 3026-3034, 2006 | 198 | 2006 |
| Store-Operated Ca2+ Entry (SOCE) Regulates Melanoma Proliferation and Cell Migration M Umemura, E Baljinnyam, S Feske, MS De Lorenzo, LH Xie, X Feng, ... PloS one 9 (2), e89292, 2014 | 193 | 2014 |
| cAMP and Epac in the regulation of tissue fibrosis PA Insel, F Murray, U Yokoyama, S Romano, H Yun, L Brown, A Snead, ... British journal of pharmacology 166 (2), 447-456, 2012 | 179 | 2012 |
| The cyclic AMP effector Epac integrates pro-and anti-fibrotic signals U Yokoyama, HH Patel, NC Lai, N Aroonsakool, DM Roth, PA Insel Proceedings of the National Academy of Sciences 105 (17), 6386-6391, 2008 | 174 | 2008 |
| Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning YM Tsutsumi, YT Horikawa, MM Jennings, MW Kidd, IR Niesman, ... Circulation 118 (19), 1979-1988, 2008 | 160 | 2008 |
| Increased smooth muscle cell expression of caveolin‐1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension HH Patel, S Zhang, F Murray, RYS Suda, BP Head, U Yokoyama, ... The FASEB Journal 21 (11), 2970-2979, 2007 | 153 | 2007 |
| Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses S Okumura, T Fujita, W Cai, M Jin, I Namekata, Y Mototani, H Jin, ... The Journal of clinical investigation 124 (6), 2785-2801, 2014 | 112 | 2014 |
| Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles I Sato, M Umemura, K Mitsudo, H Fukumura, JH Kim, Y Hoshino, ... Scientific reports 6 (1), 24629, 2016 | 98 | 2016 |
| Epac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migration U Yokoyama, S Minamisawa, H Quan, T Akaike, M Jin, K Otsu, C Ulucan, ... American Journal of Physiology-Heart and Circulatory Physiology 295 (4 …, 2008 | 91 | 2008 |
| Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A U Yokoyama, S Minamisawa, H Quan, T Akaike, S Suzuki, M Jin, Q Jiao, ... Journal of biological chemistry 283 (42), 28702-28709, 2008 | 88 | 2008 |
| Prostaglandin E2 Inhibits Elastogenesis in the Ductus Arteriosus via EP4 Signaling U Yokoyama, S Minamisawa, A Shioda, R Ishiwata, MH Jin, M Masuda, ... Circulation 129 (4), 487-496, 2014 | 87 | 2014 |
| Focal adhesions in (myo) fibroblasts scaffold adenylyl cyclase with phosphorylated caveolin JS Swaney, HH Patel, U Yokoyama, BP Head, DM Roth, PA Insel Journal of Biological Chemistry 281 (25), 17173-17179, 2006 | 86 | 2006 |
| Congenital semilunar valvulogenesis defect in mice deficient in phospholipase Cε M Tadano, H Edamatsu, S Minamisawa, U Yokoyama, Y Ishikawa, ... Molecular and cellular biology, 2005 | 85 | 2005 |
| Differential roles of Epac in regulating cell death in neuronal and myocardial cells S Suzuki, U Yokoyama, T Abe, H Kiyonari, N Yamashita, Y Kato, ... Journal of biological chemistry 285 (31), 24248-24259, 2010 | 84 | 2010 |
| Inhibition of EP4 signaling attenuates aortic aneurysm formation U Yokoyama, R Ishiwata, MH Jin, Y Kato, O Suzuki, H Jin, Y Ichikawa, ... PloS one 7 (5), e36724, 2012 | 80 | 2012 |
| Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells H Fukumura, M Sato, K Kezuka, I Sato, X Feng, S Okumura, T Fujita, ... The Journal of Physiological Sciences 62, 251-257, 2012 | 75 | 2012 |
| Regulation of vascular tone and remodeling of the ductus arteriosus U Yokoyama, S Minamisawa, Y Ishikawa Journal of Smooth Muscle Research 46 (2), 77-87, 2010 | 75 | 2010 |
| Hyperthermia and chemotherapy using Fe (Salen) nanoparticles might impact glioblastoma treatment M Ohtake, M Umemura, I Sato, T Akimoto, K Oda, A Nagasako, JH Kim, ... Scientific Reports 7 (1), 42783, 2017 | 61 | 2017 |
| The iron chelating agent, deferoxamine detoxifies Fe (Salen)-induced cytotoxicity M Umemura, JH Kim, H Aoyama, Y Hoshino, H Fukumura, R Nakakaji, ... Journal of pharmacological sciences 134 (4), 203-210, 2017 | 60 | 2017 |
