| β-Arrestin–dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2 KA DeFea, J Zalevsky, MS Thoma, O Dery, RD Mullins, NW Bunnett The Journal of cell biology 148 (6), 1267-1282, 2000 | 1012 | 2000 |
| A transmembrane form of the prion protein in neurodegenerative disease RS Hegde, JA Mastrianni, MR Scott, KA DeFea, P Tremblay, M Torchia, ... Science 279 (5352), 827-834, 1998 | 932 | 1998 |
| The proliferative and antiapoptotic effects of substance P are facilitated by formation of a β-arrestin-dependent scaffolding complex KA DeFea, ZD Vaughn, EM O'bryan, D Nishijima, O Dery, NW Bunnett Proceedings of the National Academy of Sciences 97 (20), 11086-11091, 2000 | 513 | 2000 |
| Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase K De Fea, RA Roth Journal of Biological Chemistry 272 (50), 31400-31406, 1997 | 397 | 1997 |
| Targeting proteinase-activated receptors: therapeutic potential and challenges R Ramachandran, F Noorbakhsh, K DeFea, MD Hollenberg Nature reviews Drug discovery 11 (1), 69-86, 2012 | 374 | 2012 |
| Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612 K De Fea, RA Roth Biochemistry 36 (42), 12939-12947, 1997 | 343 | 1997 |
| AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633 Z Chen, IC Peng, W Sun, MI Su, PH Hsu, Y Fu, Y Zhu, K DeFea, S Pan, ... Circulation research 104 (4), 496-505, 2009 | 327 | 2009 |
| Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway J Li, K DeFea, RA Roth Journal of Biological Chemistry 274 (14), 9351-9356, 1999 | 285 | 1999 |
| A β-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis L Ge, Y Ly, M Hollenberg, K DeFea Journal of Biological Chemistry 278 (36), 34418-34426, 2003 | 262 | 2003 |
| Transactivation of vascular endothelial growth factor receptor-2 by interleukin-8 (IL-8/CXCL8) is required for IL-8/CXCL8-induced endothelial permeability ML Petreaca, M Yao, Y Liu, K DeFea, M Martins-Green Molecular biology of the cell 18 (12), 5014-5023, 2007 | 254 | 2007 |
| Transactivation of vascular endothelial growth factor receptor-2 by interleukin-8 (IL-8/CXCL8) is required for IL-8/CXCL8-induced endothelial permeability ML Petreaca, M Yao, Y Liu, K DeFea, M Martins-Green Molecular biology of the cell 18 (12), 5014-5023, 2007 | 253 | 2007 |
| Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both β-arrestin-1 and-2 L Ge, SK Shenoy, RJ Lefkowitz, K DeFea Journal of Biological Chemistry 279 (53), 55419-55424, 2004 | 220 | 2004 |
| β‐arrestins and heterotrimeric G‐proteins: collaborators and competitors in signal transduction K Defea British journal of pharmacology 153 (S1), S298-S309, 2008 | 214 | 2008 |
| Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity Y Shi, CG Pontrello, KA DeFea, LF Reichardt, IM Ethell Journal of Neuroscience 29 (25), 8129-8142, 2009 | 189 | 2009 |
| Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2) R Ramachandran, K Mihara, H Chung, B Renaux, CS Lau, DA Muruve, ... Journal of Biological Chemistry 286 (28), 24638-24648, 2011 | 186 | 2011 |
| β-Arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2 M Zoudilova, P Kumar, L Ge, P Wang, GM Bokoch, KA DeFea Journal of Biological Chemistry 282 (28), 20634-20646, 2007 | 184 | 2007 |
| Beta-arrestins as regulators of signal termination and transduction: how do they determine what to scaffold? KA DeFea Cellular signalling 23 (4), 621-629, 2011 | 169 | 2011 |
| Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins T Lin, L Zeng, Y Liu, K DeFea, MA Schwartz, S Chien, JYJ Shyy Circulation research 92 (12), 1296-1304, 2003 | 164 | 2003 |
| Differential regulation of chemokines by IL-17 in colonic epithelial cells JW Lee, P Wang, MG Kattah, S Youssef, L Steinman, K DeFea, DS Straus The Journal of Immunology 181 (9), 6536-6545, 2008 | 156 | 2008 |
| Cofilin under control of β-arrestin-2 in NMDA-dependent dendritic spine plasticity, long-term depression (LTD), and learning CG Pontrello, MY Sun, A Lin, TA Fiacco, KA DeFea, IM Ethell Proceedings of the National Academy of Sciences 109 (7), E442-E451, 2012 | 148 | 2012 |
