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Aisha Shamas-Din
Aisha Shamas-Din
Medical and Scientific Writer, University Health Network
Verified email at uhnresearch.ca
Title
Cited by
Cited by
Year
Mechanisms of action of Bcl-2 family proteins
A Shamas-Din, J Kale, B Leber, DW Andrews
Cold Spring Harbor perspectives in biology 5 (4), a008714, 2013
8402013
Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax
JF Lovell, LP Billen, S Bindner, A Shamas-Din, C Fradin, B Leber, ...
Cell 135 (6), 1074-1084, 2008
6892008
BH3-only proteins: Orchestrators of apoptosis
A Shamas-Din, H Brahmbhatt, B Leber, DW Andrews
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1813 (4), 508-520, 2011
5002011
Bid: a Bax-like BH3 protein
LP Billen, A Shamas-Din, DW Andrews
Oncogene 27 (1), S93-S104, 2008
3652008
tBid undergoes multiple conformational changes at the membrane required for Bax activation
A Shamas-Din, S Bindner, W Zhu, Y Zaltsman, C Campbell, A Gross, ...
Journal of Biological Chemistry 288 (30), 22111-22127, 2013
1092013
Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML
SU Liyanage, R Hurren, V Voisin, G Bridon, X Wang, CJ Xu, N MacLean, ...
Blood, The Journal of the American Society of Hematology 129 (19), 2657-2666, 2017
762017
A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia
GA Reed, GJ Schiller, S Kambhampati, MS Tallman, D Douer, MD Minden, ...
Cancer medicine 5 (11), 3031-3040, 2016
622016
Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax
A Shamas-Din, S Bindner, X Chi, B Leber, DW Andrews, C Fradin
Biochemical Journal 467 (3), 495-505, 2015
602015
A phase I study of elesclomol sodium in patients with acute myeloid leukemia
D Hedley, A Shamas-Din, S Chow, D Sanfelice, AC Schuh, JM Brandwein, ...
Leukemia & lymphoma 57 (10), 2437-2440, 2016
502016
Multiple partners can kiss-and-run: Bax transfers between multiple membranes and permeabilizes those primed by tBid
A Shamas-Din, D Satsoura, O Khan, W Zhu, B Leber, C Fradin, ...
Cell death & disease 5 (6), e1277-e1277, 2014
432014
Allosteric regulation of BH3 proteins in Bcl-xL complexes enables switch-like activation of Bax
C Bogner, J Kale, J Pogmore, X Chi, A Shamas-Din, C Fradin, B Leber, ...
Molecular Cell 77 (4), 901-912. e9, 2020
362020
The proapoptotic protein tBid forms both superficially bound and membrane-inserted oligomers
S Shivakumar, M Kurylowicz, N Hirmiz, Y Manan, O Friaa, A Shamas-Din, ...
Biophysical journal 106 (10), 2085-2095, 2014
272014
A novel isoflavone, ME-344, targets the cytoskeleton in acute myeloid leukemia
DV Jeyaraju, R Hurren, X Wang, N MacLean, M Gronda, A Shamas-Din, ...
Oncotarget 7 (31), 49777, 2016
222016
Drug discovery in academia
A Shamas-Din, AD Schimmer
Experimental Hematology 43 (8), 713-717, 2015
192015
Characterizing the mitochondrial DNA polymerase gamma interactome by BioID identifies Ruvbl2 localizes to the mitochondria
SU Liyanage, E Coyaud, EMN Laurent, R Hurren, N Maclean, SR Wood, ...
Mitochondrion 32, 31-35, 2017
172017
Increased pressure alters plasma membrane dynamics and renders acute myeloid leukemia cells resistant to daunorubicin
VS Nirmalanandhan, R Hurren, WD Cameron, M Gronda, A Shamas-Din, ...
Haematologica 100 (10), e406, 2015
92015
Optimizing the Acquisition and Analysis of Confocal Images for Quantitative Single‐Mobile‐Particle Detection
O Friaa, M Furukawa, A Shamas‐Din, B Leber, DW Andrews, C Fradin
ChemPhysChem 14 (11), 2476-2490, 2013
62013
FV-162 is a novel, orally bioavailable, irreversible proteasome inhibitor with improved pharmacokinetics displaying preclinical efficacy with continuous daily dosing
Z Wang, P Dove, X Wang, A Shamas-Din, Z Li, A Nachman, YJ Oh, ...
Cell death & disease 6 (7), e1815-e1815, 2015
42015
The highly potent bromodomain (BRD) inhibitor FV-281 displays preclinical efficacy in acute myeloid leukemia (AML)
Z Wang, P Dove, A Shamas-Din, R Hurren, X Wang, N MacLean, ...
Blood, The Journal of the American Society of Hematology 126 (23), 1364-1364, 2015
12015
Binding and oligomerization of bcl-2 family proteins on supported lipid bilayers with single molecule resolution
M Kurylowicz, S Shivakumar, A Shamas-Din, B Leber, DW Andrews, ...
Biophysical Journal 104 (2), 222a, 2013
12013
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