Time-restricted eating to prevent and manage chronic metabolic diseases A Chaix, ENC Manoogian, GC Melkani, S Panda Annual review of nutrition 39 (1), 291-315, 2019 | 392 | 2019 |
Time-restricted feeding attenuates age-related cardiac decline in Drosophila S Gill, HD Le, GC Melkani, S Panda Science 347 (6227), 1265-1269, 2015 | 281 | 2015 |
Time‐restricted feeding for prevention and treatment of cardiometabolic disorders GC Melkani, S Panda The Journal of physiology 595 (12), 3691-3700, 2017 | 185 | 2017 |
Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption JE Villanueva, C Livelo, AS Trujillo, S Chandran, B Woodworth, ... Nature communications 10 (1), 2700, 2019 | 133 | 2019 |
Huntington's Disease Induced Cardiac Amyloidosis Is Reversed by Modulating Protein Folding and Oxidative Stress Pathways in the Drosophila Heart GC Melkani, AS Trujillo, R Ramos, R Bodmer, SI Bernstein, K Ocorr PLoS genetics 9 (12), e1004024, 2013 | 96 | 2013 |
Using Drosophila as an integrated model to study mild repetitive traumatic brain injury A Barekat, A Gonzalez, RE Mauntz, RW Kotzebue, B Molina, ... Scientific reports 6 (1), 25252, 2016 | 86 | 2016 |
The UNC-45 myosin chaperone: from worms to flies to vertebrates CF Lee, GC Melkani, SI Bernstein International review of cell and molecular biology 313, 103-144, 2014 | 69 | 2014 |
The UNC-45 Chaperone Is Critical for Establishing Myosin-Based Myofibrillar Organization and Cardiac Contractility in the Drosophila Heart Model GC Melkani, R Bodmer, K Ocorr, SI Bernstein PloS one 6 (7), e22579, 2011 | 68 | 2011 |
αB-crystallin maintains skeletal muscle myosin enzymatic activity and prevents its aggregation under heat-shock stress GC Melkani, A Cammarato, SI Bernstein Journal of molecular biology 358 (3), 635-645, 2006 | 66 | 2006 |
Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability CF Lee, GC Melkani, Q Yu, JA Suggs, WA Kronert, Y Suzuki, L Hipolito, ... Journal of cell science 124 (5), 699-705, 2011 | 46 | 2011 |
Increasing autophagy and blocking Nrf2 suppress laminopathy‐induced age‐dependent cardiac dysfunction and shortened lifespan S Bhide, AS Trujillo, MT O'Connor, GH Young, DE Cryderman, ... Aging cell 17 (3), e12747, 2018 | 45 | 2018 |
When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging MM Mihaylova, A Chaix, M Delibegovic, JJ Ramsey, J Bass, G Melkani, ... Cell metabolism 35 (7), 1114-1131, 2023 | 43 | 2023 |
Drosophila UNC-45 prevents heat-induced aggregation of skeletal muscle myosin and facilitates refolding of citrate synthase GC Melkani, CF Lee, A Cammarato, SI Bernstein Biochemical and biophysical research communications 396 (2), 317-322, 2010 | 40 | 2010 |
Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy WA Kronert, KM Bell, MC Viswanathan, GC Melkani, AS Trujillo, A Huang, ... Elife 7, e38064, 2018 | 36 | 2018 |
The relay/converter interface influences hydrolysis of ATP by skeletal muscle myosin II MJ Bloemink, GC Melkani, SI Bernstein, MA Geeves Journal of Biological Chemistry 291 (4), 1763-1773, 2016 | 30 | 2016 |
TRiC/CCT chaperonins are essential for maintaining myofibril organization, cardiac physiological rhythm, and lifespan GC Melkani, S Bhide, A Han, J Vyas, C Livelo, R Bodmer, SI Bernstein FEBS letters 591 (21), 3447-3458, 2017 | 27 | 2017 |
The ATPase activity of GroEL is supported at high temperatures by divalent cations that stabilize its structure GC Melkani, G Zardeneta, JA Mendoza Biometals 16, 479-484, 2003 | 24 | 2003 |
Alternative exon 9-encoded relay domains affect more than one communication pathway in the Drosophila myosin head MJ Bloemink, CM Dambacher, AF Knowles, GC Melkani, MA Geeves, ... Journal of molecular biology 389 (4), 707-721, 2009 | 22 | 2009 |
Huntington’s disease-induced cardiac disorders affect multiple cellular pathways GC Melkani Reactive oxygen species (Apex, NC) 2 (5), 325, 2016 | 21 | 2016 |
Expression of the inclusion body myopathy 3 mutation in Drosophila depresses myosin function and stability and recapitulates muscle inclusions and weakness Y Wang, GC Melkani, JA Suggs, A Melkani, WA Kronert, A Cammarato, ... Molecular biology of the cell 23 (11), 2057-2065, 2012 | 21 | 2012 |