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Rugang Zhang
Rugang Zhang
Wistar Institute
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Year
Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA
R Zhang, MV Poustovoitov, X Ye, HA Santos, W Chen, SM Daganzo, ...
Developmental cell 8 (1), 19-30, 2005
7982005
Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers
BG Bitler, KM Aird, A Garipov, H Li, M Amatangelo, AV Kossenkov, ...
Nature medicine 21 (3), 231-238, 2015
6152015
Molecular dissection of formation of senescence-associated heterochromatin foci
R Zhang, W Chen, PD Adams
Molecular and cellular biology, 2007
4622007
BET bromodomain inhibition promotes anti-tumor immunity by suppressing PD-L1 expression
H Zhu, F Bengsch, N Svoronos, MR Rutkowski, BG Bitler, MJ Allegrezza, ...
Cell reports 16 (11), 2829-2837, 2016
3722016
sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance
A Kaur, MR Webster, K Marchbank, R Behera, A Ndoye, CH Kugel, ...
Nature 532 (7598), 250-254, 2016
3532016
Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation
MR Rutkowski, TL Stephen, N Svoronos, MJ Allegrezza, AJ Tesone, ...
Cancer cell 27 (1), 27-40, 2015
3042015
Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence
KM Aird, G Zhang, H Li, Z Tu, BG Bitler, A Garipov, H Wu, Z Wei, ...
Cell reports 3 (4), 1252-1265, 2013
2842013
NAD+ metabolism governs the proinflammatory senescence-associated secretome
T Nacarelli, L Lau, T Fukumoto, J Zundell, N Fatkhutdinov, S Wu, KM Aird, ...
Nature cell biology 21 (3), 397-407, 2019
2712019
Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA-Mutant Ovarian Cancer Models
H Kim, E George, RL Ragland, S Rafail, R Zhang, C Krepler, MA Morgan, ...
Clinical Cancer Research 23 (12), 3097-3108, 2017
2532017
Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells
X Ye, B Zerlanko, A Kennedy, G Banumathy, R Zhang, PD Adams
Molecular cell 27 (2), 183-196, 2007
2442007
Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis
AL Kennedy, JP Morton, I Manoharan, DM Nelson, NB Jamieson, ...
Molecular cell 42 (1), 36-49, 2011
2262011
Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models
H Kim, H Xu, E George, D Hallberg, S Kumar, V Jagannathan, ...
Nature communications 11 (1), 3726, 2020
2132020
ARID1A-mutated ovarian cancers depend on HDAC6 activity
BG Bitler, S Wu, PH Park, Y Hai, KM Aird, Y Wang, Y Zhai, AV Kossenkov, ...
Nature cell biology 19 (8), 962-973, 2017
2122017
PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion
MC Caino, JC Ghosh, YC Chae, V Vaira, DB Rivadeneira, A Faversani, ...
Proceedings of the National Academy of Sciences 112 (28), 8638-8643, 2015
2052015
Definition of pRB-and p53-dependent and-independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci
X Ye, B Zerlanko, R Zhang, N Somaiah, M Lipinski, P Salomoni, ...
Molecular and cellular biology, 2007
1882007
Integrated analysis of genetic ancestry and genomic alterations across cancers
J Yuan, Z Hu, BA Mahal, SD Zhao, KH Kensler, J Pi, X Hu, Y Zhang, ...
Cancer cell 34 (4), 549-560. e9, 2018
1822018
Structure and function of the conserved core of histone deposition protein Asf1
SM Daganzo, JP Erzberger, WM Lam, E Skordalakes, R Zhang, ...
Current Biology 13 (24), 2148-2158, 2003
1822003
Tumor cell–independent estrogen signaling drives disease progression through mobilization of myeloid-derived suppressor cells
N Svoronos, A Perales-Puchalt, MJ Allegrezza, MR Rutkowski, KK Payne, ...
Cancer discovery 7 (1), 72-85, 2017
1802017
Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B
S Rao, SY Lee, A Gutierrez, J Perrigoue, RJ Thapa, Z Tu, JR Jeffers, ...
Blood, The Journal of the American Society of Hematology 120 (18), 3764-3773, 2012
1652012
BET bromodomain inhibition synergizes with PARP inhibitor in epithelial ovarian cancer
S Karakashev, H Zhu, Y Yokoyama, B Zhao, N Fatkhutdinov, ...
Cell reports 21 (12), 3398-3405, 2017
1622017
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