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| Synthesis of novel 3-substituted. beta.-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore MS Allen, TJ Hagen, ML Trudell, PW Codding, P Skolnick, JM Cook Journal of medicinal chemistry 31 (9), 1854-1861, 1988 | 115 | 1988 |
| Aminoacetyl moiety as a potential surrogate for diacylhydrazine group of SC-51089, a potent PGE2 antagonist, and its analogs EA Hallinan, TJ Hagen, S Tsymbalov, RK Husa, AC Lee, A Stapelfeld, ... Journal of medicinal chemistry 39 (2), 609-613, 1996 | 103 | 1996 |
| Predictive binding of. beta.-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach MS Allen, AJ LaLoggia, LJ Dorn, MJ Martin, G Costantino, TJ Hagen, ... Journal of medicinal chemistry 35 (22), 4001-4010, 1992 | 84 | 1992 |
| N-substituted dibenzoxazepines as analgesic PGE2 antagonists EA Hallinan, TJ Hagen, RK Husa, S Tsymbalov, SN Rao, JP vanHoeck, ... Journal of medicinal chemistry 36 (22), 3293-3299, 1993 | 83 | 1993 |
| 2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase TJ Hagen, AA Bergmanis, SW Kramer, KF Fok, AE Schmelzer, BS Pitzele, ... Journal of medicinal chemistry 41 (19), 3675-3683, 1998 | 76 | 1998 |
| Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms RK Webber, S Metz, WM Moore, JR Connor, MG Currie, KF Fok, ... Journal of medicinal chemistry 41 (1), 96-101, 1998 | 74 | 1998 |
| Synthetic and computer assisted analysis of the pharmacophore for agonists at benzodiazepine receptors H Diaz-Arauzo, KF Koehler, TJ Hagen, JM Cook Life sciences 49 (3), 207-216, 1991 | 74 | 1991 |
| DDQ oxidations in the indole area. Synthesis of 4-alkoxy-. Beta.-carbolines including the natural products crenatine and 1-methoxycanthin-6-one TJ Hagen, K Narayanan, J Names, JM Cook The Journal of Organic Chemistry 54 (9), 2170-2178, 1989 | 74 | 1989 |
| Synthesis of 6-substituted. beta.-carbolines that behave as benzodiazepine receptor antagonists or inverse agonists TJ Hagen, P Skolnick, JM Cook Journal of medicinal chemistry 30 (4), 750-753, 1987 | 71 | 1987 |
| Demonstration of AutoDock as an educational tool for drug discovery TR Helgren, TJ Hagen Journal of chemical education 94 (3), 345-349, 2017 | 60 | 2017 |
| Bz1 Receptor Subtype Specific Ligands. Synthesis and Biological Properties of βCCt, a Bz1 Receptor Subtype Specific Antagonist. ED Cox, TJ Hagen, RM McKernan, JM Cook ChemInform 27 (21), no-no, 1996 | 60 | 1996 |
| 2, 4-Disubstituted oxazoles and thiazoles as latent pharmacophores for diacylhydrazine of SC-51089, a potent PGE2 antagonist EA Hallinan, TJ Hagen, S Tsymbalov, A Stapelfeld, MA Savage Bioorganic & medicinal chemistry 9 (1), 1-6, 2001 | 54 | 2001 |
| Design and synthesis of selective phosphodiesterase 4D (PDE4D) allosteric inhibitors for the treatment of fragile X syndrome and other brain disorders ME Gurney, RA Nugent, X Mo, JA Sindac, TJ Hagen, D Fox III, ... Journal of medicinal chemistry 62 (10), 4884-4901, 2019 | 49 | 2019 |
| The synthesis, antimalarial activity and CoMFA analysis of novel aminoalkylated quercetin analogs TR Helgren, RJ Sciotti, P Lee, S Duffy, VM Avery, O Igbinoba, M Akoto, ... Bioorganic & medicinal chemistry letters 25 (2), 327-332, 2015 | 46 | 2015 |
| Discovery of triazines as selective PDE4B versus PDE4D inhibitors TJ Hagen, X Mo, AB Burgin, D Fox 3rd, Z Zhang, ME Gurney Bioorganic & medicinal chemistry letters 24 (16), 4031-4034, 2014 | 46 | 2014 |
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| Synthesis of 3, 6-disubstituted β-carbolines which possess either benzodiazepine antagonist or agonist activity TJ Hagen, F Guzman, C Schultz, JM Cook, P Skolnick, HE Shannon Heterocycles (Sendai) 24 (10), 2845-2855, 1986 | 39 | 1986 |
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