Kenichi Shimada
Kenichi Shimada
Laboratory of Systems Pharmacology, Harvard Medical School
Verified email at hms.harvard.edu
Title
Cited by
Cited by
Year
Regulation of ferroptotic cancer cell death by GPX4
WS Yang, R SriRamaratnam, ME Welsch, K Shimada, R Skouta, ...
Cell 156 (1-2), 317-331, 2014
16262014
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
VS Viswanathan, MJ Ryan, HD Dhruv, S Gill, OM Eichhoff, ...
Nature 547 (7664), 453-457, 2017
5122017
Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models
R Skouta, SJ Dixon, J Wang, DE Dunn, M Orman, K Shimada, ...
Journal of the American Chemical Society 136 (12), 4551-4556, 2014
4612014
Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis
K Shimada, R Skouta, A Kaplan, WS Yang, M Hayano, SJ Dixon, ...
Nature chemical biology 12 (7), 497-503, 2016
3062016
Cell-line selectivity improves the predictive power of pharmacogenomic analyses and helps identify NADPH as biomarker for ferroptosis sensitivity
K Shimada, M Hayano, NC Pagano, BR Stockwell
Cell chemical biology 23 (2), 225-235, 2016
1172016
Modulatory profiling identifies mechanisms of small molecule-induced cell death
AJ Wolpaw, K Shimada, R Skouta, ME Welsch, UD Akavia, D Pe'er, ...
Proceedings of the National Academy of Sciences 108 (39), E771-E780, 2011
1102011
Development of small-molecule probes that selectively kill cells induced to express mutant RAS
M We´wer, JA Bittker, TA Lewis, K Shimada, WS Yang, L MacPherson, ...
Bioorganic & medicinal chemistry letters 22 (4), 1822-1826, 2012
1052012
Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay
AG Herman, M Hayano, MV Poyurovsky, K Shimada, R Skouta, C Prives, ...
Cancer discovery 1 (4), 312-325, 2011
752011
Identification of simple compounds with microtubule-binding activity that inhibit cancer cell growth with high potency
WS Yang, K Shimada, D Delva, M Patel, E Ode, R Skouta, BR Stockwell
ACS medicinal chemistry letters 3 (1), 35-38, 2012
552012
Unraveling the mechanism of cell death induced by chemical fibrils
O Julien, M Kampmann, MC Bassik, JA Zorn, VJ Venditto, K Shimbo, ...
Nature chemical biology 10 (11), 969-976, 2014
472014
Design and synthesis of pictet–spengler condensation products that exhibit oncogenic-ras synthetic lethality and induce non-apoptotic cell death
R Skouta, M Hayano, K Shimada, BR Stockwell
Bioorganic & medicinal chemistry letters 22 (17), 5707-5713, 2012
302012
Copper-binding small molecule induces oxidative stress and cell-cycle arrest in glioblastoma-patient-derived cells
K Shimada, E Reznik, ME Stokes, L Krishnamoorthy, PH Bos, Y Song, ...
Cell chemical biology 25 (5), 585-594. e7, 2018
262018
Transdermal delivery of a readthrough-inducing drug: a new approach of gentamicin administration for the treatment of nonsense mutation-mediated disorders
M Shiozuka, A Wagatsuma, T Kawamoto, H Sasaki, K Shimada, ...
The journal of biochemistry 147 (4), 463-470, 2010
222010
Human pluripotency is initiated and preserved by a unique subset of founder cells
M Nakanishi, RR Mitchell, YD Benoit, L Orlando, JC Reid, K Shimada, ...
Cell 177 (4), 910-924. e22, 2019
202019
tRNA synthase suppression activates de novo cysteine synthesis to compensate for cystine and glutathione deprivation during ferroptosis
K Shimada, BR Stockwell
Molecular & cellular oncology 3 (2), e1091059, 2016
142016
Unsupervised identification of disease states from high‐dimensional physiological and histopathological profiles
K Shimada, TJ Mitchison
Molecular systems biology 15 (2), e8636, 2019
82019
Screen for RAS-selective lethal compounds and VDAC ligands
JA Bittker, M Weiwer, K Shimada, WS Yang, L MacPherson, S Dandapani, ...
probe 1, 2010
72010
Screen for RAS-selective lethal compounds and VDAC ligands-probe 2
JA Bittker, M Weiwer, T Lewis, K Shimada, WS Yang, L MacPherson, ...
Probe Reports from the NIH Molecular Libraries Program [Internet], 2011
42011
A tool for browsing the Cancer Dependency Map reveals functional connections between genes and helps predict the efficacy and selectivity of candidate cancer drugs
K Shimada, JL Muhlich, TJ Mitchison
bioRxiv, 2019
32019
Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation
JH Weng, PD Koch, HH Luan, HC Tu, K Shimada, I Ngan, R Ventura, ...
Nature metabolism 3 (4), 513-522, 2021
2021
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