Kenichi Shimada
Kenichi Shimada
Laboratory of Systems Pharmacology, Harvard Medical School
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Cited by
Cited by
Regulation of ferroptotic cancer cell death by GPX4
WS Yang, R SriRamaratnam, ME Welsch, K Shimada, R Skouta, ...
Cell 156 (1-2), 317-331, 2014
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
VS Viswanathan, MJ Ryan, HD Dhruv, S Gill, OM Eichhoff, ...
Nature 547 (7664), 453-457, 2017
Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models
R Skouta, SJ Dixon, J Wang, DE Dunn, M Orman, K Shimada, ...
Journal of the American Chemical Society 136 (12), 4551-4556, 2014
Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis
K Shimada, R Skouta, A Kaplan, WS Yang, M Hayano, SJ Dixon, ...
Nature chemical biology 12 (7), 497-503, 2016
Cell-line selectivity improves the predictive power of pharmacogenomic analyses and helps identify NADPH as biomarker for ferroptosis sensitivity
K Shimada, M Hayano, NC Pagano, BR Stockwell
Cell chemical biology 23 (2), 225-235, 2016
Modulatory profiling identifies mechanisms of small molecule-induced cell death
AJ Wolpaw, K Shimada, R Skouta, ME Welsch, UD Akavia, D Pe'er, ...
Proceedings of the National Academy of Sciences 108 (39), E771-E780, 2011
Development of small-molecule probes that selectively kill cells induced to express mutant RAS
M We´wer, JA Bittker, TA Lewis, K Shimada, WS Yang, L MacPherson, ...
Bioorganic & medicinal chemistry letters 22 (4), 1822-1826, 2012
Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay
AG Herman, M Hayano, MV Poyurovsky, K Shimada, R Skouta, C Prives, ...
Cancer discovery 1 (4), 312-325, 2011
Identification of simple compounds with microtubule-binding activity that inhibit cancer cell growth with high potency
WS Yang, K Shimada, D Delva, M Patel, E Ode, R Skouta, BR Stockwell
ACS medicinal chemistry letters 3 (1), 35-38, 2012
Unraveling the mechanism of cell death induced by chemical fibrils
O Julien, M Kampmann, MC Bassik, JA Zorn, VJ Venditto, K Shimbo, ...
Nature chemical biology 10 (11), 969-976, 2014
Design and synthesis of pictet–spengler condensation products that exhibit oncogenic-ras synthetic lethality and induce non-apoptotic cell death
R Skouta, M Hayano, K Shimada, BR Stockwell
Bioorganic & medicinal chemistry letters 22 (17), 5707-5713, 2012
Copper-binding small molecule induces oxidative stress and cell-cycle arrest in glioblastoma-patient-derived cells
K Shimada, E Reznik, ME Stokes, L Krishnamoorthy, PH Bos, Y Song, ...
Cell chemical biology 25 (5), 585-594. e7, 2018
Transdermal delivery of a readthrough-inducing drug: a new approach of gentamicin administration for the treatment of nonsense mutation-mediated disorders
M Shiozuka, A Wagatsuma, T Kawamoto, H Sasaki, K Shimada, ...
The journal of biochemistry 147 (4), 463-470, 2010
Human pluripotency is initiated and preserved by a unique subset of founder cells
M Nakanishi, RR Mitchell, YD Benoit, L Orlando, JC Reid, K Shimada, ...
Cell 177 (4), 910-924. e22, 2019
tRNA synthase suppression activates de novo cysteine synthesis to compensate for cystine and glutathione deprivation during ferroptosis
K Shimada, BR Stockwell
Molecular & cellular oncology 3 (2), e1091059, 2016
Unsupervised identification of disease states from high‐dimensional physiological and histopathological profiles
K Shimada, TJ Mitchison
Molecular systems biology 15 (2), e8636, 2019
Screen for RAS-selective lethal compounds and VDAC ligands
JA Bittker, M Weiwer, K Shimada, WS Yang, L MacPherson, S Dandapani, ...
probe 1, 2010
Screen for RAS-selective lethal compounds and VDAC ligands-probe 2
JA Bittker, M Weiwer, T Lewis, K Shimada, WS Yang, L MacPherson, ...
Probe Reports from the NIH Molecular Libraries Program [Internet], 2011
A tool for browsing the Cancer Dependency Map reveals functional connections between genes and helps predict the efficacy and selectivity of candidate cancer drugs
K Shimada, JL Muhlich, TJ Mitchison
bioRxiv, 2019
Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation
JH Weng, PD Koch, HH Luan, HC Tu, K Shimada, I Ngan, R Ventura, ...
Nature metabolism 3 (4), 513-522, 2021
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