Biosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX) HE Bullen, SC Charnaud, M Kalanon, DT Riglar, C Dekiwadia, ... Journal of Biological Chemistry 287 (11), 7871-7884, 2012 | 173 | 2012 |
Phosphatidic acid-mediated signaling regulates microneme secretion in Toxoplasma HE Bullen, Y Jia, Y Yamaryo-Botté, H Bisio, O Zhang, NK Jemelin, ... Cell host & microbe 19 (3), 349-360, 2016 | 170 | 2016 |
A novel family of Apicomplexan glideosome-associated proteins with an inner membrane-anchoring role HE Bullen, CJ Tonkin, RA O'Donnell, WH Tham, AT Papenfuss, S Gould, ... Journal of Biological Chemistry 284 (37), 25353-25363, 2009 | 150 | 2009 |
Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate NA Counihan, SA Chisholm, HE Bullen, A Srivastava, PR Sanders, ... Elife 6, e23217, 2017 | 111 | 2017 |
Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes DT Riglar, KL Rogers, E Hanssen, L Turnbull, HE Bullen, SC Charnaud, ... Nature communications 4 (1), 1415, 2013 | 100 | 2013 |
Proteomic analysis reveals novel proteins associated with the Plasmodium protein exporter PTEX and a loss of complex stability upon truncation of the core PTEX … B Elsworth, PR Sanders, T Nebl, S Batinovic, M Kalanon, CQ Nie, ... Cellular microbiology 18 (11), 1551-1569, 2016 | 81 | 2016 |
Optimization of 2-anilino 4-amino substituted quinazolines into potent antimalarial agents with oral in vivo activity PR Gilson, C Tan, KE Jarman, KN Lowes, JM Curtis, W Nguyen, ... Journal of medicinal chemistry 60 (3), 1171-1188, 2017 | 51 | 2017 |
Protein kinase A is essential for invasion of Plasmodium falciparum into human erythrocytes ML Wilde, T Triglia, D Marapana, JK Thompson, AA Kouzmitchev, ... MBio 10 (5), 10.1128/mbio. 01972-19, 2019 | 43 | 2019 |
The triumvirate of signaling molecules controlling Toxoplasma microneme exocytosis: Cyclic GMP, calcium, and phosphatidic acid HE Bullen, H Bisio, D Soldati-Favre PLoS pathogens 15 (5), e1007670, 2019 | 40 | 2019 |
Knockdown of the translocon protein EXP2 in Plasmodium falciparum reduces growth and protein export SC Charnaud, R Kumarasingha, HE Bullen, BS Crabb, PR Gilson PLoS One 13 (11), e0204785, 2018 | 38 | 2018 |
Spatial organization of protein export in malaria parasite blood stages SC Charnaud, TK Jonsdottir, PR Sanders, HE Bullen, BK Dickerman, ... Traffic 19 (8), 605-623, 2018 | 37 | 2018 |
A central role for phosphatidic acid as a lipid mediator of regulated exocytosis in apicomplexa HE Bullen, D Soldati‐Favre FEBS letters 590 (15), 2469-2481, 2016 | 33 | 2016 |
Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in Toxoplasma gondii LE Kemp, M Rusch, A Adibekian, HE Bullen, A Graindorge, C Freymond, ... Journal of Biological Chemistry 288 (38), 27002-27018, 2013 | 26 | 2013 |
A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4 PR Gilson, R Kumarasingha, J Thompson, X Zhang, JS Penington, ... Scientific Reports 9 (1), 10292, 2019 | 24 | 2019 |
Characterisation of complexes formed by parasite proteins exported into the host cell compartment of Plasmodium falciparum infected red blood cells TK Jonsdottir, NA Counihan, JK Modak, B Kouskousis, PR Sanders, ... Cellular Microbiology 23 (8), e13332, 2021 | 21 | 2021 |
A revised mechanism for how Plasmodium falciparum recruits and exports proteins into its erythrocytic host cell M Gabriela, KM Matthews, C Boshoven, B Kouskousis, TK Jonsdottir, ... PLoS Pathogens 18 (2), e1009977, 2022 | 20 | 2022 |
Disrupting the allosteric interaction between the Plasmodium falciparum cAMP-dependent kinase and its regulatory subunit DR Littler, HE Bullen, KL Harvey, T Beddoe, BS Crabb, J Rossjohn, ... Journal of Biological Chemistry 291 (49), 25375-25386, 2016 | 18 | 2016 |
Recent insights into the export of PEXEL/HTS-motif containing proteins in Plasmodium parasites HE Bullen, BS Crabb, PR Gilson Current opinion in microbiology 15 (6), 699-704, 2012 | 16 | 2012 |
Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activity TD Ashton, A Ngo, P Favuzza, HE Bullen, MR Gancheva, O Romeo, ... Bioorganic Chemistry 117, 105359, 2021 | 11 | 2021 |
The Plasmodium falciparum parasitophorous vacuole protein P113 interacts with the parasite protein export machinery and maintains normal vacuole architecture HE Bullen, PR Sanders, MG Dans, TK Jonsdottir, DT Riglar, O Looker, ... Molecular Microbiology 117 (5), 1245-1262, 2022 | 10 | 2022 |