| Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors EMJ Jia Y, Yun CH, Park E, Ercan D, Manuia M, Juarez J, Xu C, Rhee K, Chen T ... Nature 534 (7605), 129-132, 2016 | 784 | 2016 |
| Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer CDB Yasuda H, Park E, Yun CH, Sng NJ, Lucena-Araujo AR Science Translational Medisine 5 (216), 216ra177, 2013 | 546* | 2013 |
| Single and dual targeting of mutant EGFR with an allosteric inhibitor C To, J Jang, T Chen, E Park, M Mushajiang, DJH De Clercq, M Xu, ... Cancer discovery 9 (7), 926-943, 2019 | 245 | 2019 |
| Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism BG Lee, EY Park, KE Lee, H Jeon, KH Sung, H Paulsen, ... Nature structural & molecular biology 17 (4), 471-478, 2010 | 243 | 2010 |
| Architecture of autoinhibited and active BRAF–MEK1–14-3-3 complexes E Park, S Rawson, K Li, BW Kim, SB Ficarro, GGD Pino, H Sharif, ... Nature 575 (7783), 545-550, 2019 | 217 | 2019 |
| PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination–mediated DNA repair Y Hu, SA Petit, SB Ficarro, KJ Toomire, A Xie, E Lim, SA Cao, E Park, ... Cancer discovery 4 (12), 1430-1447, 2014 | 165 | 2014 |
| Mutant‐selective allosteric EGFR degraders are effective against a broad range of drug‐resistant mutations J Jang, C To, DJH De Clercq, E Park, CM Ponthier, BH Shin, ... Angewandte Chemie 132 (34), 14589-14597, 2020 | 92 | 2020 |
| Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6 E Park, N Kim, SB Ficarro, Y Zhang, BI Lee, A Cho, K Kim, AKJ Park, ... Nature structural & molecular biology 22 (9), 703-711, 2015 | 76 | 2015 |
| Structural basis of SspB-tail recognition by the zinc binding domain of ClpX EY Park, BG Lee, SB Hong, HW Kim, H Jeon, HK Song Journal of molecular biology 367 (2), 514-526, 2007 | 62 | 2007 |
| Tight-binding inhibition by α-naphthoflavone of human cytochrome P450 1A2 US Cho, EY Park, MS Dong, BS Park, K Kim, KH Kim Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1648 (1-2), 195-202, 2003 | 62 | 2003 |
| Discovery and optimization of dibenzodiazepinones as allosteric mutant-selective EGFR inhibitors DJH De Clercq, DE Heppner, C To, J Jang, E Park, CH Yun, ... ACS medicinal chemistry letters 10 (11), 1549-1553, 2019 | 59 | 2019 |
| Crystal structure of PRY-SPRY domain of human TRIM72 EY Park, OB Kwon, BC Jeong, JS Yi, CS Lee, YG Ko, HK Song Proteins-Structure Function and Bioinformatics 78 (3), 790, 2010 | 52 | 2010 |
| SPLINTS: small-molecule protein ligand interface stabilizers ES Fischer, E Park, MJ Eck, NH Thomä Current opinion in structural biology 37, 115-122, 2016 | 43 | 2016 |
| Leveraging gas-phase fragmentation pathways for improved identification and selective detection of targets modified by covalent probes SB Ficarro, CM Browne, JD Card, WM Alexander, T Zhang, E Park, ... Analytical chemistry 88 (24), 12248-12254, 2016 | 37 | 2016 |
| Structure of the formin-interaction domain of the actin nucleation-promoting factor Bud6 D Tu, BR Graziano, E Park, W Zheng, Y Li, BL Goode, MJ Eck Proceedings of the National Academy of Sciences 109 (50), E3424-E3433, 2012 | 37 | 2012 |
| Crystal structure of the Bowman–Birk inhibitor from barley seeds in ternary complex with porcine trypsin EY Park, JA Kim, HW Kim, YS Kim, HK Song Journal of molecular biology 343 (1), 173-186, 2004 | 37 | 2004 |
| Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation GL Gonzalez-Del Pino, K Li, E Park, AM Schmoker, BH Ha, MJ Eck Proceedings of the National Academy of Sciences 118 (36), e2107207118, 2021 | 35 | 2021 |
| Single and dual targeting of mutant EGFR with an allosteric inhibitor. Cancer Discov. 2019; 9: 926–943. doi: 10.1158/2159-8290 C To, J Jang, T Chen, E Park, M Mushajiang, DJH De Clercq, M Xu, ... CD-18-0903, 0 | 31 | |
| Discovery of a highly potent and broadly effective epidermal growth factor receptor and HER2 exon 20 insertion mutant inhibitor J Jang, J Son, E Park, T Kosaka, JA Saxon, DJH De Clercq, HG Choi, ... Angewandte Chemie 130 (36), 11803-11807, 2018 | 29 | 2018 |
| Probing the functional importance of the hexameric ring structure of RNase PH JM Choi, EY Park, JH Kim, SK Chang, Y Cho Journal of Biological Chemistry 279 (1), 755-764, 2004 | 27 | 2004 |
Susumu S. KobayashiBeth Israel Deaconess Medical CenterVerified email at bidmc.harvard.edu
