| Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway X Guo, G Aviles, Y Liu, R Tian, BA Unger, YHT Lin, AP Wiita, K Xu, ... Nature 579 (7799), 427-432, 2020 | 392 | 2020 |
| CRISPR interference-based platform for multimodal genetic screens in human iPSC-derived neurons R Tian, MA Gachechiladze, CH Ludwig, MT Laurie, JY Hong, D Nathaniel, ... Neuron 104 (2), 239-255. e12, 2019 | 332 | 2019 |
| Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity YJ Zhang, L Guo, PK Gonzales, TF Gendron, Y Wu, K Jansen-West, ... Science 363 (6428), eaav2606, 2019 | 206 | 2019 |
| Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis R Tian, A Abarientos, J Hong, SH Hashemi, R Yan, N Dräger, K Leng, ... Nature neuroscience 24 (7), 1020-1034, 2021 | 190 | 2021 |
| Dual gene activation and knockout screen reveals directional dependencies in genetic networks M Boettcher, R Tian, JA Blau, E Markegard, RT Wagner, D Wu, X Mo, ... Nature biotechnology 36 (2), 170-178, 2018 | 139 | 2018 |
| Early telomerase inactivation accelerates aging independently of telomere length Z Xie, KA Jay, DL Smith, Y Zhang, Z Liu, J Zheng, R Tian, H Li, ... Cell 160 (5), 928-939, 2015 | 125 | 2015 |
| Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation JJ Chen, DL Nathaniel, P Raghavan, M Nelson, R Tian, E Tse, JY Hong, ... Journal of Biological Chemistry 294 (50), 18952-18966, 2019 | 113 | 2019 |
| Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import C He, SK Tsuchiyama, QT Nguyen, EN Plyusnina, SR Terrill, S Sahibzada, ... PLoS genetics 10 (12), e1004860, 2014 | 113 | 2014 |
| BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2 AJ Samelson, QD Tran, R Robinot, L Carrau, VV Rezelj, AM Kain, M Chen, ... Nature cell biology 24 (1), 24-34, 2022 | 64* | 2022 |
| Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether SE Torres, CM Gallagher, L Plate, M Gupta, CR Liem, X Guo, R Tian, ... Elife 8, e46595, 2019 | 53 | 2019 |
| CCM-3 promotes C. elegans germline development by regulating vesicle trafficking cytokinesis and polarity S Pal, B Lant, B Yu, R Tian, J Tong, JR Krieger, MF Moran, AC Gingras, ... Current Biology 27 (6), 868-876, 2017 | 48 | 2017 |
| CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma P Ramkumar, AB Abarientos, R Tian, M Seyler, JT Leong, M Chen, ... Blood advances 4 (13), 2899-2911, 2020 | 40 | 2020 |
| A comprehensive phenotypic CRISPR-Cas9 screen of the ubiquitin pathway uncovers roles of ubiquitin ligases in mitosis FV Hundley, NS Delgado, HC Marin, KL Carr, R Tian, DP Toczyski Molecular cell 81 (6), 1319-1336. e9, 2021 | 25 | 2021 |
| Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance D Mavor, KA Barlow, D Asarnow, Y Birman, D Britain, W Chen, EM Green, ... Biology Open 7 (7), bio036103, 2018 | 20 | 2018 |
| A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling KM Semesta, R Tian, M Kampmann, M von Zastrow, NG Tsvetanova PLoS Genetics 16 (10), e1009103, 2020 | 16 | 2020 |
| Structures of ACE2–SIT1 recognized by Omicron variants of SARS-CoV-2 Y Shen, J Wang, Y Li, Y Zhang, R Tian, R Yan Cell Discovery 8 (1), 123, 2022 | 12 | 2022 |
| PIKfyve inhibition blocks endolysosomal escape of α-synuclein fibrils and spread of α-synuclein aggregation SK See, M Chen, S Bax, R Tian, A Woerman, E Tse, IE Johnson, ... bioRxiv, 2021.01. 21.427704, 2021 | 10 | 2021 |
| Mitochondrial dysfunction is signaled to the integrated stress response by OMA1, DELE1 and HRI X Guo, G Aviles, Y Liu, R Tian, BA Unger, YHT Lin, AP Wiita, K Xu, ... bioRxiv, 715896, 2019 | 9 | 2019 |
| CRISPR-based functional genomics screening in human-pluripotent-stem-cell-derived cell types K Li, M Ouyang, J Zhan, R Tian Cell Genomics 3 (5), 2023 | 7 | 2023 |
| Decoding directional genetic dependencies through orthogonal CRISPR/Cas screens M Boettcher, R Tian, J Blau, E Markegard, D Wu, A Biton, N Zaitlen, ... BioRxiv, 120170, 2017 | 7 | 2017 |
