| A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly SJ Stray, CR Bourne, S Punna, WG Lewis, MG Finn, A Zlotnick Proceedings of the National Academy of Sciences 102 (23), 8138-8143, 2005 | 304 | 2005 |
| Global structural changes in hepatitis B virus capsids induced by the assembly effector HAP1 CR Bourne, MG Finn, A Zlotnick Journal of virology 80 (22), 11055-11061, 2006 | 191 | 2006 |
| Small-molecule effectors of hepatitis B virus capsid assembly give insight into virus life cycle C Bourne, S Lee, B Venkataiah, A Lee, B Korba, MG Finn, A Zlotnick Journal of virology 82 (20), 10262-10270, 2008 | 154 | 2008 |
| Toxin-antitoxin modules are pliable switches activated by multiple protease pathways M Muthuramalingam, JC White, CR Bourne Toxins 8 (7), 214, 2016 | 105 | 2016 |
| Utility of the biosynthetic folate pathway for targets in antimicrobial discovery CR Bourne Antibiotics 3 (1), 1-28, 2014 | 100 | 2014 |
| A mutant hepatitis B virus core protein mimics inhibitors of icosahedral capsid self-assembly CR Bourne, SP Katen, MR Fulz, C Packianathan, A Zlotnick Biochemistry 48 (8), 1736-1742, 2009 | 95 | 2009 |
| In vitro screening for molecules that affect virus capsid assembly (and other protein association reactions) A Zlotnick, A Lee, CR Bourne, JM Johnson, PL Domanico, SJ Stray Nature protocols 2 (3), 490-498, 2007 | 69 | 2007 |
| Crystal structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody PA Ramsland, SS Terzyan, G Cloud, CR Bourne, W Farrugia, G Tribbick, ... Biochemical Journal 395 (3), 473-481, 2006 | 55 | 2006 |
| Inhibition of Antibiotic-Resistant Staphylococcus aureus by the Broad-Spectrum Dihydrofolate Reductase Inhibitor RAB1 CR Bourne, EW Barrow, RA Bunce, PC Bourne, KD Berlin, WW Barrow Antimicrobial agents and chemotherapy 54 (9), 3825-3833, 2010 | 50 | 2010 |
| The toxin from a ParDE toxin‐antitoxin system found in Pseudomonas aeruginosa offers protection to cells challenged with anti‐gyrase antibiotics M Muthuramalingam, JC White, T Murphy, JR Ames, CR Bourne Molecular microbiology 111 (2), 441-454, 2019 | 43 | 2019 |
| Crystal Structure of Bacillus anthracis Dihydrofolate Reductase with the Dihydrophthalazine-Based Trimethoprim Derivative RAB1 Provides a Structural … CR Bourne, RA Bunce, PC Bourne, KD Berlin, EW Barrow, WW Barrow Antimicrobial agents and chemotherapy 53 (7), 3065-3073, 2009 | 42 | 2009 |
| Identification of Novel Potential Antibiotics against Staphylococcus Using Structure-Based Drug Screening Targeting Dihydrofolate Reductase M Kobayashi, T Kinjo, Y Koseki, CR Bourne, WW Barrow, S Aoki Journal of chemical information and modeling 54 (4), 1242-1253, 2014 | 32 | 2014 |
| Synthesis and biological activity of substituted 2, 4-diaminopyrimidines that inhibit Bacillus anthracis B Nammalwar, RA Bunce, KD Berlin, CR Bourne, PC Bourne, EW Barrow, ... European journal of medicinal chemistry 54, 387-396, 2012 | 32 | 2012 |
| Inhibition of Bacterial Dihydrofolate Reductase by 6‐Alkyl‐2, 4‐diaminopyrimidines B Nammalwar, CR Bourne, RA Bunce, N Wakeham, PC Bourne, ... ChemMedChem 7 (11), 1974-1982, 2012 | 17 | 2012 |
| The Structure and Competitive Substrate Inhibition of Dihydrofolate Reductase from Enterococcus faecalis Reveal Restrictions to Cofactor Docking CR Bourne, N Wakeham, N Webb, B Nammalwar, RA Bunce, KD Berlin, ... Biochemistry 53 (7), 1228-1238, 2014 | 15 | 2014 |
| Comparison of the three‐dimensional structures of a human Bence‐Jones dimer crystallized on Earth and aboard US Space Shuttle Mission STS‐95 SS Terzyan, CR Bourne, PA Ramsland, PC Bourne, AB Edmundson Journal of Molecular Recognition 16 (2), 83-90, 2003 | 14 | 2003 |
| Structure–activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase CR Bourne, N Wakeham, B Nammalwar, V Tseitin, PC Bourne, ... Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1834 (1), 46-52, 2013 | 13 | 2013 |
| Expression of different ParE toxins results in conserved phenotypes with distinguishable classes of toxicity JR Ames, M Muthuramalingam, T Murphy, FZ Najar, CR Bourne Microbiologyopen 8 (10), e902, 2019 | 11 | 2019 |
| Modified 2, 4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracis B Nammalwar, CR Bourne, N Wakeham, PC Bourne, EW Barrow, ... Bioorganic & medicinal chemistry 23 (1), 203-211, 2015 | 11 | 2015 |
| Evaluating the potential for cross-interactions of antitoxins in type II TA systems CH Tu, M Holt, S Ruan, C Bourne Toxins 12 (6), 422, 2020 | 10 | 2020 |
