Anthony Michael Giannetti
Anthony Michael Giannetti
Caltech, Roche, Genentech, Google[X]/Verily
Verified email at
Cited by
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Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
T Maurer, LS Garrenton, A Oh, K Pitts, DJ Anderson, NJ Skelton, ...
Proceedings of the National Academy of Sciences 109 (14), 5299-5304, 2012
The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression
PJ Schmidt, PT Toran, AM Giannetti, PJ Bjorkman, NC Andrews
Cell metabolism 7 (3), 205-214, 2008
Specific Btk inhibition suppresses B cell–and myeloid cell–mediated arthritis
JA Di Paolo, T Huang, M Balazs, J Barbosa, KH Barck, BJ Bravo, ...
Nature chemical biology 7 (1), 41-50, 2011
Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination
EC Dueber, AJ Schoeffler, A Lingel, JM Elliott, AV Fedorova, AM Giannetti, ...
Science 334 (6054), 376-380, 2011
Surface plasmon resonance based assay for the detection and characterization of promiscuous inhibitors
AM Giannetti, BD Koch, MF Browner
Journal of medicinal chemistry 51 (3), 574-580, 2008
Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling
JR Haling, J Sudhamsu, I Yen, S Sideris, W Sandoval, W Phung, BJ Bravo, ...
Cancer cell 26 (3), 402-413, 2014
Molecular mechanism of the Syk activation switch
E Tsang, AM Giannetti, D Shaw, M Dinh, KY Joyce, S Gandhi, H Ho, ...
Journal of Biological Chemistry 283 (47), 32650-32659, 2008
HFE and transferrin directly compete for transferrin receptor in solution and at the cell surface
AM Giannetti, PJ Björkman
Journal of Biological Chemistry 279 (24), 25866-25875, 2004
From experimental design to validated hits: a comprehensive walk-through of fragment lead identification using surface plasmon resonance
AM Giannetti
Methods in enzymology 493, 169-218, 2011
Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites
AP West Jr, AM Giannetti, AB Herr, MJ Bennett, JS Nangiana, JR Pierce, ...
Journal of molecular biology 313 (2), 385-397, 2001
Selection and characterization of replicon variants dually resistant to thumb-and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus
S Le Pogam, H Kang, SF Harris, V Leveque, AM Giannetti, S Ali, ...
Journal of virology 80 (12), 6146-6154, 2006
Mechanism for multiple ligand recognition by the human transferrin receptor
AM Giannetti, PM Snow, O Zak, PJ Björkman
PLoS biology 1 (3), e51, 2003
Comparative analysis of 10 small molecules binding to carbonic anhydrase II by different investigators using Biacore technology
GA Papalia, S Leavitt, MA Bynum, PS Katsamba, R Wilton, H Qiu, ...
Analytical biochemistry 359 (1), 94-105, 2006
Docking for fragment inhibitors of AmpC β-lactamase
DG Teotico, K Babaoglu, GJ Rocklin, RS Ferreira, AM Giannetti, ...
Proceedings of the National Academy of Sciences 106 (18), 7455-7460, 2009
A global benchmark study using affinity-based biosensors
RL Rich, GA Papalia, PJ Flynn, J Furneisen, J Quinn, JS Klein, ...
Analytical biochemistry 386 (2), 194-216, 2009
Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus
JQ Hang, Y Yang, SF Harris, V Leveque, HJ Whittington, S Rajyaguru, ...
Journal of biological chemistry 284 (23), 15517-15529, 2009
Identification of substituted 2-thio-6-oxo-1, 6-dihydropyrimidines as inhibitors of human lactate dehydrogenase
PS Dragovich, BP Fauber, LB Corson, CZ Ding, C Eigenbrot, HX Ge, ...
Bioorganic & medicinal chemistry letters 23 (11), 3186-3194, 2013
Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors
SS Antonysamy, B Aubol, J Blaney, MF Browner, AM Giannetti, SF Harris, ...
Bioorganic & medicinal chemistry letters 18 (9), 2990-2995, 2008
Fibers of tau fragments, but not full length tau, exhibit a cross β‐structure: Implications for the formation of paired helical filaments
AM Giannetti, G Lindwall, LA Kohlstaedt, MF Chau, MJ Radeke, ...
Protein Science 9 (12), 2427-2435, 2000
Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase
BP Fauber, PS Dragovich, J Chen, LB Corson, CZ Ding, C Eigenbrot, ...
Bioorganic & medicinal chemistry letters 23 (20), 5533-5539, 2013
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