Caspases and their substrates O Julien, JA Wells Cell Death & Differentiation 24 (8), 1380-1389, 2017 | 894 | 2017 |
The DegraBase: A Database of Proteolysis in Healthy and Apoptotic Human Cells ED Crawford, JE Seaman, N Agard, GW Hsu, O Julien, S Mahrus, ... Molecular & Cellular Proteomics 12 (3), 813-824, 2013 | 168 | 2013 |
Mapping interactions with the chaperone network reveals factors that protect against tau aggregation SA Mok, C Condello, R Freilich, A Gillies, T Arhar, J Oroz, H Kadavath, ... Nature structural & molecular biology 25 (5), 384-393, 2018 | 156 | 2018 |
Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles O Julien, M Zhuang, AP Wiita, AJ O’Donoghue, GM Knudsen, CS Craik, ... Proceedings of the National Academy of Sciences 113 (14), E2001-E2010, 2016 | 124 | 2016 |
Deorphanizing caspase-3 and caspase-9 substrates in and out of apoptosis with deep substrate profiling LE Araya, IV Soni, JA Hardy, O Julien ACS Chemical Biology 16 (11), 2280-2296, 2021 | 115 | 2021 |
Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau R Freilich, M Betegon, E Tse, SA Mok, O Julien, DA Agard, ... Nature Communications 9 (1), 4563, 2018 | 99 | 2018 |
Comparative analysis of mitochondrial N-termini from mouse, human, and yeast SE Calvo, O Julien, KR Clauser, H Shen, KJ Kamer, JA Wells, VK Mootha Molecular & Cellular Proteomics 16 (4), 512-523, 2017 | 95 | 2017 |
Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins AJ Martinko, C Truillet, O Julien, JE Diaz, MA Horlbeck, G Whiteley, ... eLife 7, e31098, 2018 | 94 | 2018 |
Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues JE Seaman, O Julien, PS Lee, TJ Rettenmaier, ND Thomsen, JA Wells Cell Death & Differentiation 23 (10), 1717-1726, 2016 | 92 | 2016 |
Global cellular response to chemotherapy-induced apoptosis AP Wiita, E Ziv, PJ Wiita, A Urisman, O Julien, AL Burlingame, ... Elife 2, e01236, 2013 | 82 | 2013 |
The Unique Cofactor Region of Zika Virus NS2B–NS3 Protease Facilitates Cleavage of Key Host Proteins ME Hill, A Kumar, JA Wells, TC Hobman, O Julien, JA Hardy ACS chemical biology 13 (9), 2398-2405, 2018 | 70 | 2018 |
Unraveling the mechanism of cell death induced by chemical fibrils O Julien, M Kampmann, MC Bassik, JA Zorn, VJ Venditto, K Shimbo, ... Nature chemical biology 10 (11), 969-976, 2014 | 56 | 2014 |
Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies SB Pollock, A Hu, Y Mou, AJ Martinko, O Julien, M Hornsby, L Ploder, ... Proceedings of the National Academy of Sciences 115 (11), 2836-2841, 2018 | 54 | 2018 |
Structure–activity relationship and molecular mechanics reveal the importance of ring entropy in the biosynthesis and activity of a natural product HL Tran, KW Lexa, O Julien, TS Young, CT Walsh, MP Jacobson, ... Journal of the American Chemical Society 139 (7), 2541-2544, 2017 | 54 | 2017 |
Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades SR Srinivasan, LC Cesa, X Li, O Julien, M Zhuang, H Shao, J Chung, ... Molecular Cancer Research 16 (1), 58-68, 2018 | 53 | 2018 |
Reprogramming Caspase-7 specificity by regio-specific mutations and selection provides alternate solutions for substrate recognition ME Hill, DJ MacPherson, P Wu, O Julien, JA Wells, JA Hardy ACS chemical biology 11 (6), 1603-1612, 2016 | 45 | 2016 |
Turning on caspases with genetics and small molecules CW Morgan, O Julien, EK Unger, NM Shah, JA Wells Methods in enzymology 544, 179-213, 2014 | 44 | 2014 |
SARS-CoV-2 Mpro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals SA Chen, E Arutyunova, J Lu, MB Khan, W Rut, M Zmudzinski, S Shahbaz, ... ACS Central Science 9 (4), 696-708, 2023 | 42 | 2023 |
Differential stability of the bovine prion protein upon urea unfolding O Julien, S Chatterjee, A Thiessen, SP Graether, BD Sykes Protein Science 18 (10), 2172-2182, 2009 | 42 | 2009 |
Protease substrate identification using N-terminomics SY Luo, LE Araya, O Julien ACS Chemical Biology 14 (11), 2361-2371, 2019 | 39 | 2019 |