Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts Y Kojima, A Acar, EN Eaton, KT Mellody, C Scheel, I Ben-Porath, ... Proceedings of the National Academy of Sciences 107 (46), 20009-20014, 2010 | 899 | 2010 |
Anti-estrogen resistance in human breast tumors is driven by JAG1-NOTCH4-dependent cancer stem cell activity BM Simoes, CS O’Brien, R Eyre, A Silva, L Yu, A Sarmiento-Castro, ... Cell reports 12 (12), 1968-1977, 2015 | 189 | 2015 |
TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer S Busch, A Acar, Y Magnusson, P Gregersson, L Rydén, G Landberg Oncogene 34 (1), 27-38, 2013 | 117 | 2013 |
Subclonal reconstruction of tumors by using machine learning and population genetics G Caravagna, T Heide, MJ Williams, L Zapata, D Nichol, K Chkhaidze, ... Nature genetics 52 (9), 898-907, 2020 | 99 | 2020 |
Exploiting evolutionary steering to induce collateral drug sensitivity in cancer A Acar, D Nichol, J Fernandez-Mateos, GD Cresswell, I Barozzi, SP Hong, ... Nature communications 11 (1), 1923, 2020 | 99 | 2020 |
Dishevelled limits Notch signalling through inhibition of CSL GM Collu, A Hidalgo-Sastre, A Acar, L Bayston, C Gildea, MK Leverentz, ... Development 139 (23), 4405-4415, 2012 | 85 | 2012 |
A role for notch signalling in breast cancer and endocrine resistance A Acar, BM Simões, RB Clarke, K Brennan Stem cells international 2016, 2016 | 82 | 2016 |
Evolutionary dynamics of residual disease in human glioblastoma I Spiteri, G Caravagna, GD Cresswell, A Vatsiou, D Nichol, A Acar, ... Annals of Oncology 30 (3), 456-463, 2019 | 68 | 2019 |
The spatiotemporal evolution of lymph node spread in early breast cancer P Barry, A Vatsiou, I Spiteri, D Nichol, GD Cresswell, A Acar, N Trahearn, ... Clinical Cancer Research 24 (19), 4763-4770, 2018 | 38 | 2018 |
Inhibition of Wnt signalling by Notch via two distinct mechanisms A Acar, A Hidalgo-Sastrem, MK Leverentz, CG Mills, W Simon, B Martin, ... Scientific Reports, 9096, 2021 | 33 | 2021 |
Experimental generation of carcinoma-associated fibroblasts (CAFs) from human mammary fibroblasts UM Polanska, A Acar, A Orimo JoVE (Journal of Visualized Experiments), e3201, 2011 | 28 | 2011 |
Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors L Zapata, G Caravagna, MJ Williams, E Lakatos, K AbdulJabbar, ... Nature Genetics 55 (3), 451-460, 2023 | 20 | 2023 |
Systems biology and experimental model systems of cancer GD Yalcin, N Danisik, RC Baygin, A Acar Journal of Personalized Medicine 10 (4), 180, 2020 | 18 | 2020 |
Increased TRIM31 gene expression is positively correlated with SARS-CoV-2 associated genes TMPRSS2 and TMPRSS4 in gastrointestinal cancers MA Temena, A Acar Scientific Reports 12 (1), 11763, 2022 | 11 | 2022 |
Identification of collateral sensitivity and evolutionary landscape of chemotherapy-induced drug resistance using cellular barcoding technology N Danisik, KC Yilmaz, A Acar Frontiers in Pharmacology 14, 1178489, 2023 | 2 | 2023 |
Pan-Cancer Analysis of the COVID-19 Causal Gene SLC6A20 A Acar ACS omega 8 (14), 13153-13161, 2023 | 1 | 2023 |
Epigenetic heritability of cell plasticity drives cancer drug resistance through one-to-many genotype to phenotype mapping J Fernandez-Mateos, S Milite, E Oliveira, G Vlachogiannis, B Chen, ... bioRxiv, 2023.11. 15.567140, 2023 | 1 | 2023 |
Cancer evolution L Ermini, D Mallo, D Kleftogiannis, A Acar Frontiers in Genetics 14, 633, 2023 | 1 | 2023 |
Notch: evidence for combining therapies to treat breast cancer MK Leverentz, A Acar, K Brennan Breast Cancer Management 2 (6), 481-488, 2013 | 1 | 2013 |
Tumor-Microenvironment-on-Chip Platform for Assessing Drug Response in 3D Dynamic Culture HB Aydin, H Moon, B Han, A Ozcelikkale, A Acar 3D Cell Culture: Methods and Protocols, 265-278, 2024 | | 2024 |