The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS K Mori, SM Weng, T Arzberger, S May, K Rentzsch, E Kremmer, B Schmid, ... Science 339 (6125), 1335-1338, 2013 | 1375 | 2013 |
Reconstitution of γ-secretase activity D Edbauer, E Winkler, JT Regula, B Pesold, H Steiner, C Haass Nature cell biology 5 (5), 486-488, 2003 | 1232 | 2003 |
ALS‐associated fused in sarcoma (FUS) mutations disrupt Transportin‐mediated nuclear import D Dormann, R Rodde, D Edbauer, E Bentmann, I Fischer, A Hruscha, ... The EMBO journal 29 (16), 2841-2857, 2010 | 914 | 2010 |
Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132 D Edbauer, JR Neilson, KA Foster, CF Wang, DP Seeburg, MN Batterton, ... Neuron 65 (3), 373-384, 2010 | 875 | 2010 |
Gain of toxicity from ALS/FTD-linked repeat expansions in C9ORF72 is alleviated by antisense oligonucleotides targeting GGGGCC-containing RNAs J Jiang, Q Zhu, TF Gendron, S Saberi, M McAlonis-Downes, A Seelman, ... Neuron 90 (3), 535-550, 2016 | 558 | 2016 |
Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins K Mori, T Arzberger, FA Grässer, I Gijselinck, S May, K Rentzsch, ... Acta neuropathologica 126, 881-893, 2013 | 538 | 2013 |
C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits J Chew, TF Gendron, M Prudencio, H Sasaguri, YJ Zhang, ... Science 348 (6239), 1151-1154, 2015 | 454 | 2015 |
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE S Parhizkar, T Arzberger, M Brendel, G Kleinberger, M Deussing, C Focke, ... Nature neuroscience 22 (2), 191-204, 2019 | 442 | 2019 |
PEN-2 is an integral component of the γ-secretase complex required for coordinated expression of presenilin and nicastrin H Steiner, E Winkler, D Edbauer, S Prokop, G Basset, A Yamasaki, ... Journal of Biological Chemistry 277 (42), 39062-39065, 2002 | 423 | 2002 |
hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations K Mori, S Lammich, IRA Mackenzie, I Forné, S Zilow, H Kretzschmar, ... Acta neuropathologica 125, 413-423, 2013 | 401 | 2013 |
Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Aβ-like peptide S Lammich, M Okochi, M Takeda, C Kaether, A Capell, AK Zimmer, ... Journal of Biological Chemistry 277 (47), 44754-44759, 2002 | 390 | 2002 |
Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations IR Mackenzie, T Arzberger, E Kremmer, D Troost, S Lorenzl, K Mori, ... Acta neuropathologica 126, 859-879, 2013 | 388 | 2013 |
microRNA‐34c is a novel target to treat dementias A Zovoilis, HY Agbemenyah, RC Agis‐Balboa, RM Stilling, D Edbauer, ... The EMBO journal 30 (20), 4299-4308, 2011 | 378 | 2011 |
In situ structure of neuronal C9orf72 poly-GA aggregates reveals proteasome recruitment Q Guo, C Lehmer, A Martínez-Sánchez, T Rudack, F Beck, H Hartmann, ... Cell 172 (4), 696-705. e12, 2018 | 375 | 2018 |
C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration S May, D Hornburg, MH Schludi, T Arzberger, K Rentzsch, BM Schwenk, ... Acta neuropathologica 128, 485-503, 2014 | 372 | 2014 |
MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function BH Miller, Z Zeier, L Xi, TA Lanz, S Deng, J Strathmann, D Willoughby, ... Proceedings of the National Academy of Sciences 109 (8), 3125-3130, 2012 | 356 | 2012 |
Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions J Cooper-Knock, MJ Walsh, A Higginbottom, J Robin Highley, ... Brain 137 (7), 2040-2051, 2014 | 348 | 2014 |
Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation D Edbauer, E Winkler, C Haass, H Steiner Proceedings of the National Academy of Sciences 99 (13), 8666-8671, 2002 | 341 | 2002 |
Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ42 production T Moehlmann, E Winkler, X Xia, D Edbauer, J Murrell, A Capell, C Kaether, ... Proceedings of the National Academy of Sciences 99 (12), 8025-8030, 2002 | 330 | 2002 |
Micro RNA‐125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease J Banzhaf‐Strathmann, E Benito, S May, T Arzberger, S Tahirovic, ... The EMBO journal 33 (15), 1667-1680, 2014 | 325 | 2014 |