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Isaac Canals
Isaac Canals
Verified email at med.lu.se
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Rapid and efficient induction of functional astrocytes from human pluripotent stem cells
I Canals, A Ginisty, E Quist, R Timmerman, J Fritze, G Miskinyte, E Monni, ...
Nature methods 15 (9), 693-696, 2018
1782018
Therapeutic strategies based on modified U1 snRNAs and chaperones for Sanfilippo C splicing mutations
L Matos, I Canals, L Dridi, Y Choi, MJ Prata, P Jordan, LR Desviat, ...
Orphanet journal of rare diseases 9, 1-12, 2014
492014
Activity and high-order effective connectivity alterations in Sanfilippo C patient-specific neuronal networks
I Canals, J Soriano, JG Orlandi, R Torrent, Y Richaud-Patin, ...
Stem cell reports 5 (4), 546-557, 2015
412015
EXTL2 and EXTL3 inhibition with siRNAs as a promising substrate reduction therapy for Sanfilippo C syndrome
I Canals, N Benetó, M Cozar, L Vilageliu, D Grinberg
Scientific reports 5 (1), 13654, 2015
352015
Molecular analysis of Sanfilippo syndrome type C in Spain: seven novel HGSNAT mutations and characterization of the mutant alleles
I Canals, SC Elalaoui, M Pineda, V Delgadillo, M Szlago, IC Jaouad, ...
Clinical Genetics 80 (4), 367-374, 2011
342011
Sanfilippo syndrome: molecular basis, disease models and therapeutic approaches
N Benetó, L Vilageliu, D Grinberg, I Canals
International Journal of Molecular Sciences 21 (21), 7819, 2020
282020
Mitochondrial dysfunction and calcium dysregulation in leigh syndrome induced pluripotent stem cell derived neurons
T Galera-Monge, F Zurita-Díaz, I Canals, M Grønning Hansen, ...
International Journal of Molecular Sciences 21 (9), 3191, 2020
202020
Neuronal and astrocytic differentiation from Sanfilippo C syndrome iPSCs for disease modeling and drug development
N Benetó, M Cozar, L Castilla-Vallmanya, OG Zetterdahl, M Sacultanu, ...
Journal of Clinical Medicine 9 (3), 644, 2020
132020
Transcription factor-based direct conversion of human fibroblasts to functional astrocytes
E Quist, F Trovato, N Avaliani, OG Zetterdahl, A Gonzalez-Ramos, ...
Stem Cell Reports 17 (7), 1620-1635, 2022
112022
NGN2 mmRNA-Based Transcriptional Programming in Microfluidic Guides hiPSCs Toward Neural Fate With Multiple Identities
AM Tolomeo, C Laterza, E Grespan, F Michielin, I Canals, Z Kokaia, ...
Frontiers in Cellular Neuroscience 15, 602888, 2021
112021
Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence
L Oburoglu, E Mansell, I Canals, V Sigurdsson, C Guibentif, S Soneji, ...
EMBO reports 23 (2), e54384, 2022
102022
Generation of two compound heterozygous HGSNAT-mutated lines from healthy induced pluripotent stem cells using CRISPR/Cas9 to model Sanfilippo C syndrome
N Benetó, M Cozar, M García-Morant, E Creus-Bachiller, ...
Stem Cell Research, 2019, vol. 41, num. 101616, p. 1-5, 2019
102019
In vitro functional characterization of human neurons and astrocytes using calcium imaging and electrophysiology
MG Hansen, D Tornero, I Canals, H Ahlenius, Z Kokaia
Neural stem cells: methods and protocols, 73-88, 2019
102019
Transcription factor-based strategies to generate neural cell types from human pluripotent stem cells
I Canals, E Quist, H Ahlenius
Cellular Reprogramming 23 (4), 206-220, 2021
92021
Serial magnetic resonance imaging and neurophysiological studies in multiple sulphatase deficiency
DI Zafeiriou, E Vargiami, K Papadopoulou, E Dimitriou, I Mavridou, ...
European Journal of Paediatric Neurology 12 (3), 190-194, 2008
82008
Transcription factor programming of human pluripotent stem cells to functionally mature astrocytes for monocultures and cocultures with neurons
E Quist, H Ahlenius, I Canals
Neural Reprogramming: Methods and Protocols, 133-148, 2021
72021
Generation of two NAGLU-mutated homozygous cell lines from healthy induced pluripotent stem cells using CRISPR/Cas9 to model Sanfilippo B syndrome
N Benetó, M Cozar, L Gort i Mas, L Pacheco, L Vilageliu i Arqués, ...
Stem Cell Research, 2020, vol. 42, p. 101668, 2020
72020
Innovative treatments for mucopolysaccharidoses
FB Lagler
Journal of Child Science 8 (01), e163-e171, 2018
52018
FOXO1 regulates pentose phosphate pathway-mediated induction of developmental erythropoiesis
A Monsalve, I Canals, L Oburoglu
Frontiers in cell and developmental biology 10, 1039636, 2022
32022
CRISPR/Cas9 genome engineering in human pluripotent stem cells for modeling of neurological disorders
I Canals, H Ahlenius
Neural Reprogramming: Methods and Protocols, 237-251, 2021
32021
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