Peter Madrid
Peter Madrid
VP, SRI Biosciences
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A systematic screen of FDA-approved drugs for inhibitors of biological threat agents
PB Madrid, S Chopra, ID Manger, L Gilfillan, TR Keepers, AC Shurtleff, ...
PloS one 8 (4), e60579, 2013
Evaluation of Ebola virus inhibitors for drug repurposing
PB Madrid, RG Panchal, TK Warren, AC Shurtleff, AN Endsley, CE Green, ...
ACS infectious diseases 1 (7), 317-326, 2015
Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities
PB Madrid, J Sherrill, AP Liou, JL Weisman, JL DeRisi, RK Guy
Bioorganic & medicinal chemistry letters 15 (4), 1015-1018, 2005
Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum: Role of β-haematin …
DC Warhurst, JC Craig, IS Adagu, RK Guy, PB Madrid, QL Fivelman
Biochemical pharmacology 73 (12), 1910-1926, 2007
Incorporation of an Intramolecular Hydrogen-Bonding Motif in the Side Chain of 4-Aminoquinolines Enhances Activity against Drug-Resistant P. falciparum
PB Madrid, AP Liou, JL DeRisi, RK Guy
Journal of medicinal chemistry 49 (15), 4535-4543, 2006
Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum
MO Anderson, J Sherrill, PB Madrid, AP Liou, JL Weisman, JL DeRisi, ...
Bioorganic & medicinal chemistry 14 (2), 334-343, 2006
Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis
S Chopra, K Matsuyama, T Tran, JP Malerich, B Wan, SG Franzblau, ...
Journal of antimicrobial chemotherapy 67 (2), 415-421, 2012
Synthesis and antitubercular activity of phenothiazines with reduced binding to dopamine and serotonin receptors
PB Madrid, WE Polgar, L Toll, MJ Tanga
Bioorganic & medicinal chemistry letters 17 (11), 3014-3017, 2007
Parallel synthesis and antimalarial screening of a 4-aminoquinoline library
PB Madrid, NT Wilson, JL DeRisi, RK Guy
Journal of combinatorial chemistry 6 (3), 437-442, 2004
Synthesis and testing of a focused phenothiazine library for binding to HIV-1 TAR RNA
M Mayer, PT Lang, S Gerber, PB Madrid, IG Pinto, RK Guy, TL James
Chemistry & biology 13 (9), 993-1000, 2006
Machine learning models identify molecules active against the Ebola virus in vitro
S Ekins, JS Freundlich, AM Clark, M Anantpadma, RA Davey, P Madrid
F1000Research 4, 2015
Identification of antimicrobial activity among FDA-approved drugs for combating Mycobacterium abscessus and Mycobacterium chelonae
S Chopra, K Matsuyama, C Hutson, P Madrid
Journal of Antimicrobial Chemotherapy 66 (7), 1533-1536, 2011
Acylideneoxoindoles: a new class of reversible inhibitors of human transglutaminase 2
C Klöck, X Jin, K Choi, C Khosla, PB Madrid, A Spencer, BC Raimundo, ...
Bioorganic & medicinal chemistry letters 21 (9), 2692-2696, 2011
Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models
S Ray, PB Madrid, P Catz, SE LeValley, MJ Furniss, LL Rausch, RK Guy, ...
Journal of medicinal chemistry 53 (9), 3685-3695, 2010
The natural product eugenol is an inhibitor of the ebola virus in vitro
T Lane, M Anantpadma, JS Freundlich, RA Davey, PB Madrid, S Ekins
Pharmaceutical research 36 (7), 1-6, 2019
Repurposing FDA-approved drugs to combat drug-resistant Acinetobacter baumannii
S Chopra, M Torres-Ortiz, L Hokama, P Madrid, M Tanga, K Mortelmans, ...
Journal of antimicrobial chemotherapy 65 (12), 2598-2601, 2010
Efficacy of tilorone dihydrochloride against Ebola virus infection
S Ekins, MA Lingerfelt, JE Comer, AN Freiberg, JC Mirsalis, K O'Loughlin, ...
Antimicrobial agents and chemotherapy 62 (2), e01711-17, 2018
SU11248 (sunitinib) directly inhibits the activity of mammalian 5'-AMP-activated protein kinase (AMPK)
K Laderoute, JM Calaoagan, PB Madrid, AE Klon, PJ Ehrlich
Cancer biology & therapy 10 (1), 68-76, 2010
Tilorone: a broad-spectrum antiviral invented in the USA and commercialized in Russia and beyond
S Ekins, TR Lane, PB Madrid
Pharmaceutical research 37 (4), 1-8, 2020
Structure–activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells
BCH May, J Witkop, J Sherrill, MO Anderson, PB Madrid, JA Zorn, ...
Bioorganic & medicinal chemistry letters 16 (18), 4913-4916, 2006
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