Randall W. King

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Marc KirschnerProfessor of Systems Biology, Harvard Medical SchoolVerified email at hms.harvard.edu
Jan-Michael PetersResearch Institute of Molecular Pathology (IMP)Verified email at imp.ac.at
Nathaniel A. HathawayAssociate Professor, the UNC Eshelman School of Pharmacy, Chemical Biology and Medicinal ChemistryVerified email at unc.edu
Frederic SigoillotNovartis - NIBR - Chemical Biology and Therapeutics - Data ScienceVerified email at novartis.com
Suzanne Elsasser, PhDResearch Associate, Harvard Medical SchoolVerified email at hms.harvard.edu
Stephen J. Haggarty, PhDHarvard Medical School, MGHVerified email at mgh.harvard.edu
Raymond DeshaiesSenior Vice President of Global Research, AmgenVerified email at caltech.edu
Min Jae LeeSeoul National University College of MedicineVerified email at snu.ac.kr
Don KirkpatrickSVP, Xaira TherapeuticsVerified email at xaira.com
Guillaume NormandNovartisVerified email at novartis.com
Thomas U. MayerUniversity of KonstanzVerified email at uni-konstanz.de
Jeremy F. HuckinsVP of R&D at Biocogniv Inc.Verified email at biocogniv.com
Xiaobo ZhouProfessor, Fellow of AIMBE and ACMI, University of Texas Health Science Center HoustonVerified email at uth.tmc.edu
Stephen T WongJohn Dunn Presidential Distinguished Chair Professor, Houston Methodist and Cornell UniversityVerified email at houstonmethodist.org
Philip HieterProfessorVerified email at msl.ubc.ca
Hongtao YuChair Professor of Cell Biology, School of Life Sciences, Westlake UniversityVerified email at westlake.edu.cn
P Todd StukenbergUniversity of VirginiaVerified email at virginia.edu
Kevin LustigScientist.comVerified email at scientist.com
Michael GlotzerProfessor of Molecular Genetics and Cell Biology, University of ChicagoVerified email at uchicago.edu
JOAN BRUGGEHarvard Medical SchoolVerified email at hms.harvard.edu

Randall W. King

Professor of Cell Biology, Harvard Medical School

Verified email at hms.harvard.edu

Cell Division Chemical Biology Ubiquitin-Dependent Proteolysis


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Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen TU Mayer, TM Kapoor, SJ Haggarty, RW King, SL Schreiber, TJ Mitchison Science 286 (5441), 971-974, 1999	2316	1999
How proteolysis drives the cell cycle RW King, RJ Deshaies, JM Peters, MW Kirschner Science 274 (5293), 1652-1659, 1996	1755	1996
A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B RW King, JM Peters, S Tugendreich, M Rolfe, P Hieter, MW Kirschner Cell 81 (2), 279-288, 1995	1217	1995
Enhancement of proteasome activity by a small-molecule inhibitor of USP14 BH Lee, MJ Lee, S Park, DC Oh, S Elsasser, PC Chen, C Gartner, ... Nature 467 (7312), 179-184, 2010	1059	2010
Mitosis in transition RW King, PK Jackson, MW Kirschner Cell 79 (4), 563-571, 1994	1047	1994
A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion M Overholtzer, AA Mailleux, G Mouneimne, G Normand, SJ Schnitt, ... Cell 131 (5), 966-979, 2007	834	2007
Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor SL Holloway, M Glotzer, RW King, AW Murray Cell 73 (7), 1393-1402, 1993	724	1993
Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology DS Kirkpatrick, NA Hathaway, J Hanna, S Elsasser, J Rush, D Finley, ... Nature cell biology 8 (7), 700-710, 2006	529	2006
A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response B Adamson, A Smogorzewska, FD Sigoillot, RW King, SJ Elledge Nature cell biology 14 (3), 318-328, 2012	493	2012
Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines Q Shi, RW King Nature 437 (7061), 1038-1042, 2005	475	2005
Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation J Hanna, NA Hathaway, Y Tone, B Crosas, S Elsasser, DS Kirkpatrick, ... Cell 127 (1), 99-111, 2006	444	2006
Small molecule regulators of protein arginine methyltransferases D Cheng, N Yadav, RW King, MS Swanson, EJ Weinstein, MT Bedford Journal of Biological Chemistry 279 (23), 23892-23899, 2004	417	2004
Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates. RW King, M Glotzer, MW Kirschner Molecular biology of the cell 7 (9), 1343-1357, 1996	392	1996
Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis SJ Haggarty, TU Mayer, DT Miyamoto, R Fathi, RW King, TJ Mitchison, ... Chemistry & biology 7 (4), 275-286, 2000	380	2000
Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities B Crosas, J Hanna, DS Kirkpatrick, DP Zhang, Y Tone, NA Hathaway, ... Cell 127 (7), 1401-1413, 2006	375	2006
Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage X Zeng, F Sigoillot, S Gaur, S Choi, KL Pfaff, DC Oh, N Hathaway, ... Cancer cell 18 (4), 382-395, 2010	352	2010
Identification of a cullin homology region in a subunit of the anaphase-promoting complex H Yu, JM Peters, RW King, AM Page, P Hieter, MW Kirschner Science 279 (5354), 1219-1222, 1998	341	1998
Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes MJ Lee, BH Lee, J Hanna, RW King, D Finley Molecular & Cellular Proteomics 10 (5), 2011	301	2011
Systematic identification of mitotic phosphoproteins PT Stukenberg, KD Lustig, TJ McGarry, RW King, J Kuang, MW Kirschner Current Biology 7 (5), 338-348, 1997	286	1997
Identification of BIME as a subunit of the anaphase-promoting complex JM Peters, RW King, C Höög, MW Kirschner Science 274 (5290), 1199-1201, 1996	264	1996

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