Jörg Lippert
Jörg Lippert
Bayer AG
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Applied concepts in PBPK modeling: how to build a PBPK/PD model
L Kuepfer, C Niederalt, T Wendl, JF Schlender, S Willmann, J Lippert, ...
CPT: pharmacometrics & systems pharmacology 5 (10), 516-531, 2016
A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks
T Eissing, L Kuepfer, C Becker, M Block, K Coboeken, T Gaub, L Goerlitz, ...
Frontiers in physiology 2, 4, 2011
Good practices in model‐informed drug discovery and development: practice, application, and documentation
EFPIA MID3 Workgroup, SF Marshall, R Burghaus, V Cosson, ...
CPT: pharmacometrics & systems pharmacology 5 (3), 93-122, 2016
Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs
S Willmann, K Höhn, A Edginton, M Sevestre, J Solodenko, W Weiss, ...
Journal of pharmacokinetics and pharmacodynamics 34, 401-431, 2007
A physiological model for the estimation of the fraction dose absorbed in humans
S Willmann, W Schmitt, J Keldenich, J Lippert, JB Dressman
Journal of medicinal chemistry 47 (16), 4022-4031, 2004
PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’model
S Willmann, J Lippert, M Sevestre, J Solodenko, F Fois, W Schmitt
Biosilico 1 (4), 121-124, 2003
Risk to the breast‐fed neonate from codeine treatment to the mother: a quantitative mechanistic modeling study
S Willmann, AN Edginton, K Coboeken, G Ahr, J Lippert
Clinical Pharmacology & Therapeutics 86 (6), 634-643, 2009
Smart medical information technology for healthcare (SMITH)
A Winter, S Stäubert, D Ammon, S Aiche, O Beyan, V Bischoff, P Daumke, ...
Methods of information in medicine 57 (S 01), e92-e105, 2018
Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, part 1: oral solutions
K Thelen, K Coboeken, S Willmann, R Burghaus, JB Dressman, J Lippert
Journal of pharmaceutical sciences 100 (12), 5324-5345, 2011
Integrating cellular metabolism into a multiscale whole-body model
M Krauss, S Schaller, S Borchers, R Findeisen, J Lippert, L Kuepfer
PLoS computational biology 8 (10), e1002750, 2012
From physicochemistry to absorption and distribution: predictive mechanistic modelling and computational tools
S Willmann, J Lippert, W Schmitt
Expert opinion on drug metabolism & toxicology 1 (1), 159-168, 2005
The virtual liver: a multidisciplinary, multilevel challenge for systems biology
HG Holzhütter, D Drasdo, T Preusser, J Lippert, AM Henney
Wiley Interdisciplinary Reviews: Systems Biology and Medicine 4 (3), 221-235, 2012
Using expression data for quantification of active processes in physiologically based pharmacokinetic modeling
M Meyer, S Schneckener, B Ludewig, L Kuepfer, J Lippert
Drug Metabolism and Disposition 40 (5), 892-901, 2012
A generic integrated physiologically based whole‐body model of the glucose‐insulin‐glucagon regulatory system
S Schaller, S Willmann, J Lippert, L Schaupp, TR Pieber, A Schuppert, ...
CPT: pharmacometrics & systems pharmacology 2 (8), 1-10, 2013
Development of a paediatric population-based model of the pharmacokinetics of rivaroxaban
S Willmann, C Becker, R Burghaus, K Coboeken, A Edginton, J Lippert, ...
Clinical pharmacokinetics 53, 89-102, 2014
Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, part II: extension to describe performance of solid …
K Thelen, K Coboeken, S Willmann, JB Dressman, J Lippert
Journal of pharmaceutical sciences 101 (3), 1267-1280, 2012
A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim
C Niederalt, L Kuepfer, J Solodenko, T Eissing, HU Siegmund, M Block, ...
Journal of pharmacokinetics and pharmacodynamics 45, 235-257, 2018
Open systems pharmacology community—an open access, open source, open science approach to modeling and simulation in pharmaceutical sciences
J Lippert, R Burghaus, A Edginton, S Frechen, M Karlsson, A Kovar, ...
CPT: pharmacometrics & systems pharmacology 8 (12), 878, 2019
Development of a physiologically-based pharmacokinetic model for preterm neonates: evaluation with in vivo data
K Claassen, K Thelen, K Coboeken, T Gaub, J Lippert, K Allegaert, ...
Current pharmaceutical design 21 (39), 5688-5698, 2015
Mechanism-based prediction of particle size-dependent dissolution and absorption: cilostazol pharmacokinetics in dogs
S Willmann, K Thelen, C Becker, JB Dressman, J Lippert
European journal of pharmaceutics and biopharmaceutics 76 (1), 83-94, 2010
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