| Applied concepts in PBPK modeling: how to build a PBPK/PD model L Kuepfer, C Niederalt, T Wendl, JF Schlender, S Willmann, J Lippert, ... CPT: pharmacometrics & systems pharmacology 5 (10), 516-531, 2016 | 356 | 2016 |
| Good practices in model‐informed drug discovery and development: practice, application, and documentation EFPIA MID3 Workgroup, SF Marshall, R Burghaus, V Cosson, ... CPT: pharmacometrics & systems pharmacology 5 (3), 93-122, 2016 | 285 | 2016 |
| A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks T Eissing, L Kuepfer, C Becker, M Block, K Coboeken, T Gaub, L Goerlitz, ... Frontiers in physiology 2, 4, 2011 | 274 | 2011 |
| Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs S Willmann, K Höhn, A Edginton, M Sevestre, J Solodenko, W Weiss, ... Journal of pharmacokinetics and pharmacodynamics 34, 401-431, 2007 | 263 | 2007 |
| A physiological model for the estimation of the fraction dose absorbed in humans S Willmann, W Schmitt, J Keldenich, J Lippert, JB Dressman Journal of medicinal chemistry 47 (16), 4022-4031, 2004 | 256 | 2004 |
| PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’model S Willmann, J Lippert, M Sevestre, J Solodenko, F Fois, W Schmitt Biosilico 1 (4), 121-124, 2003 | 227 | 2003 |
| Smart medical information technology for healthcare (SMITH) A Winter, S Stäubert, D Ammon, S Aiche, O Beyan, V Bischoff, P Daumke, ... Methods of information in medicine 57 (S 01), e92-e105, 2018 | 171 | 2018 |
| Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, part 1: oral solutions K Thelen, K Coboeken, S Willmann, R Burghaus, JB Dressman, J Lippert Journal of pharmaceutical sciences 100 (12), 5324-5345, 2011 | 157 | 2011 |
| Risk to the breast‐fed neonate from codeine treatment to the mother: a quantitative mechanistic modeling study S Willmann, AN Edginton, K Coboeken, G Ahr, J Lippert Clinical Pharmacology & Therapeutics 86 (6), 634-643, 2009 | 156 | 2009 |
| From physicochemistry to absorption and distribution: predictive mechanistic modelling and computational tools S Willmann, J Lippert, W Schmitt Expert opinion on drug metabolism & toxicology 1 (1), 159-168, 2005 | 143 | 2005 |
| Integrating cellular metabolism into a multiscale whole-body model M Krauss, S Schaller, S Borchers, R Findeisen, J Lippert, L Kuepfer PLoS computational biology 8 (10), e1002750, 2012 | 140 | 2012 |
| The virtual liver: a multidisciplinary, multilevel challenge for systems biology HG Holzhütter, D Drasdo, T Preusser, J Lippert, AM Henney Wiley Interdisciplinary Reviews: Systems Biology and Medicine 4 (3), 221-235, 2012 | 125 | 2012 |
| Using expression data for quantification of active processes in physiologically based pharmacokinetic modeling M Meyer, S Schneckener, B Ludewig, L Kuepfer, J Lippert Drug Metabolism and Disposition 40 (5), 892-901, 2012 | 104 | 2012 |
| Open systems pharmacology community—an open access, open source, open science approach to modeling and simulation in pharmaceutical sciences J Lippert, R Burghaus, A Edginton, S Frechen, M Karlsson, A Kovar, ... CPT: pharmacometrics & systems pharmacology 8 (12), 878, 2019 | 93 | 2019 |
| A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim C Niederalt, L Kuepfer, J Solodenko, T Eissing, HU Siegmund, M Block, ... Journal of pharmacokinetics and pharmacodynamics 45, 235-257, 2018 | 92 | 2018 |
| A generic integrated physiologically based whole‐body model of the glucose‐insulin‐glucagon regulatory system S Schaller, S Willmann, J Lippert, L Schaupp, TR Pieber, A Schuppert, ... CPT: pharmacometrics & systems pharmacology 2 (8), 1-10, 2013 | 89 | 2013 |
| Development of a paediatric population-based model of the pharmacokinetics of rivaroxaban S Willmann, C Becker, R Burghaus, K Coboeken, A Edginton, J Lippert, ... Clinical pharmacokinetics 53, 89-102, 2014 | 86 | 2014 |
| Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, part II: extension to describe performance of solid … K Thelen, K Coboeken, S Willmann, JB Dressman, J Lippert Journal of pharmaceutical sciences 101 (3), 1267-1280, 2012 | 86 | 2012 |
| Development of a physiologically-based pharmacokinetic model for preterm neonates: evaluation with in vivo data K Claassen, K Thelen, K Coboeken, T Gaub, J Lippert, K Allegaert, ... Current pharmaceutical design 21 (39), 5688-5698, 2015 | 73 | 2015 |
| Mechanism-based prediction of particle size-dependent dissolution and absorption: cilostazol pharmacokinetics in dogs S Willmann, K Thelen, C Becker, JB Dressman, J Lippert European journal of pharmaceutics and biopharmaceutics 76 (1), 83-94, 2010 | 70 | 2010 |
Thomas EissingBayer AGVerified email at bayer.com
