Synthesis and Structure−Activity Relationships of Truncated Bisubstrate Inhibitors of Aminoglycoside 6‘-N-Acetyltransferases F Gao, X Yan, T Shakya, OM Baettig, S Ait-Mohand-Brunet, AM Berghuis, ... Journal of medicinal chemistry 49 (17), 5273-5281, 2006 | 115 | 2006 |
A small molecule discrimination map of the antibiotic resistance kinome T Shakya, PJ Stogios, N Waglechner, E Evdokimova, L Ejim, ... Chemistry & Biology 18 (12), 1591-1601, 2011 | 89 | 2011 |
Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance PJ Stogios, P Spanogiannopoulos, E Evdokimova, O Egorova, T Shakya, ... Biochemical Journal 454 (2), 191-200, 2013 | 58 | 2013 |
Inhibition of the ANT (2 ″)-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones DR Hirsch, G Cox, MP D’Erasmo, T Shakya, C Meck, N Mohd, GD Wright, ... Bioorganic & medicinal chemistry letters 24 (21), 4943-4947, 2014 | 52 | 2014 |
Nucleotide selectivity of antibiotic kinases T Shakya, GD Wright Antimicrobial agents and chemotherapy 54 (5), 1909-1913, 2010 | 43 | 2010 |
Structure and Function of APH (4)-Ia, a Hygromycin B Resistance Enzyme*♦ PJ Stogios, T Shakya, E Evdokimova, A Savchenko, GD Wright Journal of biological chemistry 286 (3), 1966-1975, 2011 | 40 | 2011 |
Microwave-assisted synthesis of N1-and C3-substituted pyrazolo [3, 4-d] pyrimidine libraries N Todorovic, E Awuah, T Shakya, GD Wright, A Capretta Tetrahedron letters 52 (44), 5761-5763, 2011 | 36 | 2011 |
Mechanisms of aminoglycoside antibiotic resistance T Shakya, GD Wright Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery, 119-140, 2007 | 21 | 2007 |
Identification and characterization of new inhibitors of fungal homoserine kinase G De Pascale, EJ Griffiths, T Shakya, I Nazi, GD Wright ChemBioChem 12 (8), 1179-1182, 2011 | 8 | 2011 |
GD Wright in Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery T Shakya John Wiley & Sons, Hoboken, 2007 | 7 | 2007 |
A chemical biology approach to probing aminoglycoside phosphotransferase structure and function T Shakya, GD Wright BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 86 (2), 193-193, 2008 | | 2008 |