| Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat/fructose diet and sedentary lifestyle JK Dowman, LJ Hopkins, GM Reynolds, N Nikolaou, MJ Armstrong, ... The American journal of pathology 184 (5), 1550-1561, 2014 | 132 | 2014 |
| Loss of 5α-reductase type 1 accelerates the development of hepatic steatosis but protects against hepatocellular carcinoma in male mice JK Dowman, LJ Hopkins, GM Reynolds, MJ Armstrong, M Nasiri, ... Endocrinology 154 (12), 4536-4547, 2013 | 91 | 2013 |
| Dual-5α-reductase inhibition promotes hepatic lipid accumulation in man JM Hazlehurst, AI Oprescu, N Nikolaou, R Di Guida, AEK Grinbergs, ... The Journal of Clinical Endocrinology & Metabolism 101 (1), 103-113, 2016 | 73 | 2016 |
| Modified-release and conventional glucocorticoids and diurnal androgen excretion in congenital adrenal hyperplasia CM Jones, A Mallappa, N Reisch, N Nikolaou, N Krone, BA Hughes, ... The Journal of Clinical Endocrinology & Metabolism 102 (6), 1797-1806, 2017 | 66 | 2017 |
| AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease N Nikolaou, LL Gathercole, L Marchand, S Althari, NJ Dempster, ... Metabolism 99, 67-80, 2019 | 60 | 2019 |
| 5α-Reductase type 2 regulates glucocorticoid action and metabolic phenotype in human hepatocytes M Nasiri, N Nikolaou, S Parajes, NP Krone, G Valsamakis, G Mastorakos, ... Endocrinology 156 (8), 2863-2871, 2015 | 48 | 2015 |
| Optimizing human hepatocyte models for metabolic phenotype and function: effects of treatment with dimethyl sulfoxide (DMSO) N Nikolaou, CJ Green, PJ Gunn, L Hodson, JW Tomlinson Physiological reports 4 (21), e12944, 2016 | 42 | 2016 |
| The A-ring reduction of 11-ketotestosterone is efficiently catalysed by AKR1D1 and SRD5A2 but not SRD5A1 L Barnard, N Nikolaou, C Louw, L Schiffer, H Gibson, LC Gilligan, ... The Journal of steroid biochemistry and molecular biology 202, 105724, 2020 | 19 | 2020 |
| AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells N Nikolaou, LL Gathercole, L Kirkwood, JE Dunford, BA Hughes, ... The Journal of steroid biochemistry and molecular biology 189, 218-227, 2019 | 18 | 2019 |
| 11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial N Othonos, R Pofi, A Arvaniti, S White, I Bonaventura, N Nikolaou, ... Nature Communications 14 (1), 1025, 2023 | 11 | 2023 |
| The role of 5-reduction in physiology and metabolic disease: evidence from cellular, pre-clinical and human studies N Nikolaou, L Hodson, JW Tomlinson The Journal of Steroid Biochemistry and Molecular Biology 207, 105808, 2021 | 11 | 2021 |
| Acute intermittent hypoxia drives hepatic de novo lipogenesis in humans and rodents JM Hazlehurst, TR Lim, C Charlton, JJ Miller, LL Gathercole, T Cornfield, ... Metabolism open 14, 100177, 2022 | 9 | 2022 |
| Co-administration of 5α-reductase inhibitors worsens the adverse metabolic effects of prescribed glucocorticoids N Othonos, T Marjot, C Woods, JM Hazlehurst, N Nikolaou, R Pofi, ... The Journal of Clinical Endocrinology & Metabolism 105 (9), e3316-e3328, 2020 | 9 | 2020 |
| Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo N Nikolaou, A Arvaniti, N Appanna, A Sharp, BA Hughes, D Digweed, ... Journal of Endocrinology 245 (2), 207-218, 2020 | 8 | 2020 |
| AKR1D1 knockout mice develop a sex-dependent metabolic phenotype LL Gathercole, N Nikolaou, SE Harris, A Arvaniti, TM Poolman, ... Journal of Endocrinology 253 (3), 97-113, 2022 | 7 | 2022 |
| Differential activity and expression of human 5β-reductase (AKR1D1) splice variants N Appanna, H Gibson, E Gangitano, NJ Dempster, K Morris, S George, ... Journal of molecular endocrinology 66 (3), 181-194, 2021 | 4 | 2021 |
| Gender specific metabolic phenotype in the 5 [beta]-reductase knockout mouse L Gathercole, P Klusonova, N Nikolaou, J Hazlehurst, A Moolla, ... Endocrine Abstracts 49, 2017 | 3 | 2017 |
| AKR1D1 knockdown identifies 7 [alpha]-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA) as a driver of metabolic dysfunction and hepatocellular cancer risk in patients with non … N Nikolaou, A Arvaniti, F Sanna, N Dempster, L Gathercole, J Tomlinson Endocrine abstracts 81, 2022 | 1 | 2022 |
| The american lifestyle induced obesity syndrome (ALIOS) diet induces an increase in intestinal permeability and exacerbates inflammation in female and male mice via the TLR4 … A Anastasia, N Nikolaou, S Harris, R Cox, D Corridoni, W Xin, ... Endocrine Abstracts 73, 2021 | 1 | 2021 |
| Akr1d1-/- mice have a sexually dimorphic metabolic phenotype with reduced fat mass, increased insulin sensitivity and hypertriglyceridemia in males LL Gathercole, N Nikolaou, A Arvaniti, SE Harris, TM Poolman, ... bioRxiv, 2021.02. 02.429227, 2021 | 1 | 2021 |
Jeremy TomlinsonUniversity of OxfordVerified email at ocdem.ox.ac.uk
