Luigi Martino
Luigi Martino
Wellcome Trust
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LUBAC-recruited CYLD and A20 regulate gene activation and cell death by exerting opposing effects on linear ubiquitin in signaling complexes
P Draber, S Kupka, M Reichert, H Draberova, E Lafont, D de Miguel, ...
Cell reports 13 (10), 2258-2272, 2015
Structural and thermodynamic studies of the interaction of distamycin A with the parallel quadruplex structure [d (TGGGGT)] 4
L Martino, A Virno, B Pagano, A Virgilio, S Di Micco, A Galeone, ...
Journal of the American Chemical Society 129 (51), 16048-16056, 2007
Stability and binding properties of a modified thrombin binding aptamer
B Pagano, L Martino, A Randazzo, C Giancola
Biophysical journal 94 (2), 562-569, 2008
Shedding light on the interaction between TMPyP4 and human telomeric quadruplexes
L Martino, B Pagano, I Fotticchia, S Neidle, C Giancola
The Journal of Physical Chemistry B 113 (44), 14779-14786, 2009
La-related protein 4 binds poly (A), interacts with the poly (A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability
R Yang, SA Gaidamakov, J Xie, J Lee, L Martino, G Kozlov, AK Crawford, ...
Molecular and cellular biology 31 (3), 542-556, 2011
SPATA2-mediated binding of CYLD to HOIP enables CYLD recruitment to signaling complexes
S Kupka, D De Miguel, P Draber, L Martino, S Surinova, K Rittinger, ...
Cell reports 16 (9), 2271-2280, 2016
A new modified thrombin binding aptamer containing a 5′–5′ inversion of polarity site
L Martino, A Virno, A Randazzo, A Virgilio, V Esposito, C Giancola, ...
Nucleic acids research 34 (22), 6653-6662, 2006
Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1
GF De Nicola, ED Martin, A Chaikuad, R Bassi, J Clark, L Martino, ...
Nature structural & molecular biology 20 (10), 1182-1190, 2013
Fragment-based covalent ligand screening enables rapid discovery of inhibitors for the RBR E3 ubiquitin ligase HOIP
H Johansson, YC Isabella Tsai, K Fantom, CW Chung, S Kümper, ...
Journal of the American Chemical Society 141 (6), 2703-2712, 2019
Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein
L Martino, S Pennell, G Kelly, TTT Bui, O Kotik-Kogan, SJ Smerdon, ...
Nucleic acids research 40 (3), 1381-1394, 2012
Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module
L Martino, S Pennell, G Kelly, B Busi, P Brown, RA Atkinson, ...
Nucleic acids research 43 (1), 645-660, 2015
Synthesis, biophysical characterization, and anti-HIV activity of glyco-conjugated G-quadruplex-forming oligonucleotides
J D’Onofrio, L Petraccone, L Martino, GD Fabio, A Iadonisi, J Balzarini, ...
Bioconjugate chemistry 19 (3), 607-616, 2008
The association of a La module with the PABP-interacting motif PAM2 is a recurrent evolutionary process that led to the neofunctionalization of La-related proteins
R Merret, L Martino, C Bousquet-Antonelli, S Fneich, J Descombin, ...
Rna 19 (1), 36-50, 2013
The interaction of the Escherichia coli protein SlyD with nickel ions illuminates the mechanism of regulation of its peptidyl‐prolyl isomerase activity
L Martino, Y He, KLD Hands‐Taylor, ER Valentine, G Kelly, C Giancola, ...
The FEBS journal 276 (16), 4529-4544, 2009
5'-Modified G-quadruplex forming oligonucleotides endowed with anti-HIV activity: Synthesis and biophysical properties
J D'Onofrio, L Petraccone, E Erra, L Martino, G Di Fabio, L De Napoli, ...
Bioconjugate chemistry 18 (4), 1194-1204, 2007
Structural basis for the glycosyltransferase activity of the Salmonella effector SseK3
D Esposito, RA Günster, L Martino, K El Omari, A Wagner, TLM Thurston, ...
Journal of Biological Chemistry 293 (14), 5064-5078, 2018
Structural studies of HHARI/UbcH7∼ Ub reveal unique E2∼ Ub conformational restriction by RBR RING1
KK Dove, JL Olszewski, L Martino, DM Duda, XS Wu, DJ Miller, KH Reiter, ...
Structure 25 (6), 890-900. e5, 2017
Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA
KLD Hands-Taylor, L Martino, R Tata, JJ Babon, TT Bui, AF Drake, ...
Nucleic acids research 38 (12), 4052-4066, 2010
Effects of abasic sites on structural, thermodynamic and kinetic properties of quadruplex structures
V Esposito, L Martino, G Citarella, A Virgilio, L Mayol, C Giancola, ...
Nucleic acids research 38 (6), 2069-2080, 2010
A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies
R Trotta, S De Tito, I Lauri, V La Pietra, L Marinelli, S Cosconati, L Martino, ...
Biochimie 93 (8), 1280-1287, 2011
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