Gene therapy for Leber hereditary optic neuropathy: initial results WJ Feuer, JC Schiffman, JL Davis, V Porciatti, P Gonzalez, RD Koilkonda, ... Ophthalmology 123 (3), 558-570, 2016 | 238 | 2016 |
Gene therapy for Leber hereditary optic neuropathy: low-and medium-dose visual results J Guy, WJ Feuer, JL Davis, V Porciatti, PJ Gonzalez, RD Koilkonda, ... Ophthalmology 124 (11), 1621-1634, 2017 | 201 | 2017 |
Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber’s hereditary optic neuropathy in a mouse model H Yu, RD Koilkonda, TH Chou, V Porciatti, SS Ozdemir, V Chiodo, ... Proceedings of the National Academy of Sciences 109 (20), E1238-E1247, 2012 | 181 | 2012 |
Safety and effects of the vector for the Leber hereditary optic neuropathy gene therapy clinical trial RD Koilkonda, H Yu, TH Chou, WJ Feuer, M Ruggeri, V Porciatti, D Tse, ... JAMA ophthalmology 132 (4), 409-420, 2014 | 113 | 2014 |
Efficiency and safety of AAV-mediated gene delivery of the human ND4 complex I subunit in the mouse visual system J Guy, X Qi, RD Koilkonda, T Arguello, TH Chou, M Ruggeri, V Porciatti, ... Investigative ophthalmology & visual science 50 (9), 4205-4214, 2009 | 103 | 2009 |
Leber's hereditary optic neuropathy-gene therapy: from benchtop to bedside RD Koilkonda, J Guy Journal of ophthalmology 2011, 2011 | 82 | 2011 |
Glaucoma-associated CYP1B1 mutations share similar haplotype backgrounds in POAG and PACG phenotypes S Chakrabarti, KR Devi, S Komatireddy, K Kaur, RS Parikh, AK Mandal, ... Investigative ophthalmology & visual science 48 (12), 5439-5444, 2007 | 74 | 2007 |
Gln48His is the prevalent myocilin mutation in primary open angle and primary congenital glaucoma phenotypes in India S Chakrabarti, K Kaur, S Komatireddy, M Acharya, KR Devi, ... Molecular vision 11, 111-113, 2005 | 69 | 2005 |
LHON gene therapy vector prevents visual loss and optic neuropathy induced by G11778A mutant mitochondrial DNA: biodistribution and toxicology profile R Koilkonda, H Yu, V Talla, V Porciatti, WJ Feuer, WW Hauswirth, ... Investigative ophthalmology & visual science 55 (12), 7739-7753, 2014 | 59 | 2014 |
Induction of rapid and highly efficient expression of the human ND4 complex I subunit in the mouse visual system by self-complementary adeno-associated virus RD Koilkonda, TH Chou, V Porciatti, WW Hauswirth, J Guy Archives of ophthalmology 128 (7), 876-883, 2010 | 53 | 2010 |
Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in mice H Yu, SS Ozdemir, RD Koilkonda, TH Chou, V Porciatti, V Chiodo, ... Molecular Vision 18, 1668, 2012 | 49 | 2012 |
Efficient expression of self-complementary AAV in ganglion cells of the ex vivo primate retina RD Koilkonda, WW Hauswirth, J Guy Molecular vision 15, 2796, 2009 | 35 | 2009 |
Consequences of zygote injection and germline transfer of mutant human mitochondrial DNA in mice H Yu, RD Koilkonda, TH Chou, V Porciatti, A Mehta, ID Hentall, ... Proceedings of the National Academy of Sciences 112 (42), E5689-E5698, 2015 | 31 | 2015 |
Complex I subunit gene therapy with NDUFA6 ameliorates neurodegeneration in EAE V Talla, R Koilkonda, V Porciatti, V Chiodo, SL Boye, WW Hauswirth, ... Investigative ophthalmology & visual science 56 (2), 1129-1140, 2015 | 24 | 2015 |
Noninvasive assessments of optic nerve neurodegeneration in transgenic mice with isolated optic neuritis V Talla, C Yang, G Shaw, V Porciatti, RD Koilkonda, J Guy Investigative ophthalmology & visual science 54 (7), 4440-4450, 2013 | 23 | 2013 |
Gene therapy with single-subunit yeast NADH-ubiquinone oxidoreductase (NDI1) improves the visual function in experimental autoimmune encephalomyelitis (EAE) mice model of … V Talla, R Koilkonda, J Guy Molecular neurobiology 57 (4), 1952-1965, 2020 | 13 | 2020 |
Gene therapy for LHON suppresses neurodegeneration J Guy, RD Koilkonda, WJ Feuer, JL Davis, V Porciatti, P Gonzalez, ... Investigative Ophthalmology & Visual Science 58 (8), 4492-4492, 2017 | 2 | 2017 |
Gene therapy for LHON: low and medium dose results (S26. 004) J Guy, W Feuer, J Davis, V Porciatti, P Gonzalez, R Koilkonda, H Yuan, ... Neurology 88 (16_supplement), S26. 004, 2017 | 1 | 2017 |
Early functional and long-term rescue of the LHON mouse with wild-type human ND4 gene delivery RD Koilkonda, TH Chou, M Ruggeri, V Porciatti, WW Hauswirth, V Chiodo, ... Investigative Ophthalmology & Visual Science 52 (14), 1416-1416, 2011 | 1 | 2011 |
Self-Complementary AAV Induces Rapid and Highly Efficient Allotopic Expression of the Human ND4 Complex I Subunit in the Mouse Visual System RD Koilkonda, TH Chou, V Porciatti, WW Hauswirth, J Guy Investigative Ophthalmology & Visual Science 51 (13), 4494-4494, 2010 | 1 | 2010 |