| Cancer stem cell definitions and terminology: the devil is in the details P Valent, D Bonnet, R De Maria, T Lapidot, M Copland, JV Melo, ... Nature Reviews Cancer 12 (11), 767-775, 2012 | 807 | 2012 |
| Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line: pathways that are shared with and distinct from IL-10 D Lejeune, L Dumoutier, S Constantinescu, W Kruijer, JJ Schuringa, ... Journal of Biological Chemistry 277 (37), 33676-33682, 2002 | 575 | 2002 |
| Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6 JJ Schuringa, ATJ Wierenga, W Kruijer, E Vellenga Blood, The Journal of the American Society of Hematology 95 (12), 3765-3770, 2000 | 238 | 2000 |
| Repression of BMI1 in normal and leukemic human CD34+ cells impairs self-renewal and induces apoptosis A Rizo, S Olthof, L Han, E Vellenga, G De Haan, JJ Schuringa Blood, The Journal of the American Society of Hematology 114 (8), 1498-1505, 2009 | 172 | 2009 |
| Signaling pathways in self-renewing hematopoietic and leukemic stem cells: do all stem cells need a niche? A Rizo, E Vellenga, G de Haan, JJ Schuringa Human molecular genetics 15 (suppl_2), R210-R219, 2006 | 169 | 2006 |
| Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation JJ Schuringa, KY Chung, G Morrone, MAS Moore The Journal of experimental medicine 200 (5), 623-635, 2004 | 159 | 2004 |
| Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma RWJ Groen, WA Noort, RA Raymakers, HJ Prins, L Aalders, FM Hofhuis, ... Blood, The Journal of the American Society of Hematology 120 (3), e9-e16, 2012 | 156 | 2012 |
| Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation JJ Schuringa, H Schepers, E Vellenga, W Kruijer FEBS letters 495 (1-2), 71-76, 2001 | 155 | 2001 |
| Long-term maintenance of human hematopoietic stem/progenitor cells by expression of BMI1 A Rizo, B Dontje, E Vellenga, G de Haan, JJ Schuringa Blood, The Journal of the American Society of Hematology 111 (5), 2621-2630, 2008 | 145 | 2008 |
| Non-canonical PRC1. 1 targets active genes independent of H3K27me3 and is essential for leukemogenesis V van den Boom, H Maat, M Geugien, AR López, AM Sotoca, J Jaques, ... Cell reports 14 (2), 332-346, 2016 | 144 | 2016 |
| Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components JJ SCHURINGA, LJC JONK, WHA DOKTER, E VELLENGA, W KRUIJER Biochemical Journal 347 (1), 89-96, 2000 | 142 | 2000 |
| Gene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML HJM de Jonge, CM Woolthuis, AZ Vos, A Mulder, E van den Berg, ... Leukemia 25 (12), 1825-1833, 2011 | 139 | 2011 |
| STAT5 is required for long-term maintenance of normal and leukemic human stem/progenitor cells H Schepers, D van Gosliga, ATJ Wierenga, BJL Eggen, JJ Schuringa, ... Blood, The Journal of the American Society of Hematology 110 (8), 2880-2888, 2007 | 130 | 2007 |
| Bone marrow dysfunction in chronic heart failure patients BD Westenbrink, AA Voors, RA de Boer, JJ Schuringa, T Klinkenberg, ... European Journal of Heart Failure 12 (7), 676-684, 2010 | 126 | 2010 |
| MEN2A-RET-induced cellular transformation by activation of STAT3 JJ Schuringa, K Wojtachnio, W Hagens, E Vellenga, CHCM Buys, ... Oncogene 20 (38), 5350-5358, 2001 | 123 | 2001 |
| Establishing long-term cultures with self-renewing acute myeloid leukemia stem/progenitor cells D van Gosliga, H Schepers, A Rizo, D van der Kolk, E Vellenga, ... Experimental hematology 35 (10), 1538-1549, 2007 | 116 | 2007 |
| Sequential activation of Rac-1, SEK-1/MKK-4, and protein kinase Cδ is required for interleukin-6-induced STAT3 Ser-727 phosphorylation and transactivation JJ Schuringa, LV Dekker, E Vellenga, W Kruijer Journal of Biological Chemistry 276 (29), 27709-27715, 2001 | 115 | 2001 |
| Maximal STAT5-induced proliferation and self-renewal at intermediate STAT5 activity levels ATJ Wierenga, E Vellenga, JJ Schuringa Molecular and cellular biology 28 (21), 6668-6680, 2008 | 109 | 2008 |
| MLL–AF9-mediated immortalization of human hematopoietic cells along different lineages changes during ontogeny SJ Horton, J Jaques, C Woolthuis, J Van Dijk, M Mesuraca, G Huls, ... Leukemia 27 (5), 1116-1126, 2013 | 103 | 2013 |
| A proteomics and transcriptomics approach to identify leukemic stem cell (LSC) markers F Bonardi, F Fusetti, P Deelen, D van Gosliga, E Vellenga, JJ Schuringa Molecular & Cellular Proteomics 12 (3), 626-637, 2013 | 103 | 2013 |
