Stephen M. Sykes
Stephen M. Sykes
Fox Chase Cancer Center
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Acetylation of the p53 DNA-binding domain regulates apoptosis induction
SM Sykes, HS Mellert, MA Holbert, K Li, R Marmorstein, WS Lane, ...
Molecular cell 24 (6), 841-851, 2006
The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression
XY Zhang, M Varthi, SM Sykes, C Phillips, C Warzecha, W Zhu, A Wyce, ...
Molecular cell 29 (1), 102-111, 2008
The p53 family and programmed cell death
EC Pietsch, SM Sykes, SB McMahon, ME Murphy
Oncogene 27 (50), 6507-6521, 2008
Diabetes impairs hematopoietic stem cell mobilization by altering niche function
F Ferraro, S Lymperi, S Méndez-Ferrer, B Saez, JA Spencer, BY Yeap, ...
Science translational medicine 3 (104), 104ra101-104ra101, 2011
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias
SM Sykes, SW Lane, L Bullinger, D Kalaitzidis, R Yusuf, B Saez, F Ferraro, ...
Cell 146 (5), 697-708, 2011
Requirement for CDK6 in MLL-rearranged acute myeloid leukemia
T Placke, K Faber, A Nonami, SL Putwain, HR Salih, FH Heidel, A Krämer, ...
Blood, The Journal of the American Society of Hematology 124 (1), 13-23, 2014
Menin associates with FANCD2, a protein involved in repair of DNA damage
S Jin, H Mao, RW Schnepp, SM Sykes, AC Silva, AD D’Andrea, X Hua
Cancer research 63 (14), 4204-4210, 2003
mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis
D Kalaitzidis, SM Sykes, Z Wang, N Punt, Y Tang, C Ragu, AU Sinha, ...
Cell stem cell 11 (3), 429-439, 2012
Differential niche and Wnt requirements during acute myeloid leukemia progression
SW Lane, YJ Wang, C Lo Celso, C Ragu, L Bullinger, SM Sykes, ...
Blood, The Journal of the American Society of Hematology 118 (10), 2849-2856, 2011
Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1
K Parmar, J Kim, SM Sykes, A Shimamura, P Stuckert, K Zhu, A Hamilton, ...
Stem cells 28 (7), 1186-1195, 2010
The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS
SW Lane, SM Sykes, F Al-Shahrour, S Shterental, M Paktinat, C Lo Celso, ...
Blood, The Journal of the American Society of Hematology 115 (17), 3489-3497, 2010
Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53
SM Sykes, TJ Stanek, A Frank, ME Murphy, SB McMahon
Journal of Biological Chemistry 284 (30), 20197-20205, 2009
Menin induces apoptosis in murine embryonic fibroblasts
RW Schnepp, H Mao, SM Sykes, WX Zong, A Silva, P La, X Hua
Journal of Biological Chemistry 279 (11), 10685-10691, 2004
BRCA1 mutation-specific responses to 53BP1 loss-induced homologous recombination and PARP inhibitor resistance
J Nacson, JJ Krais, AJ Bernhardy, E Clausen, W Feng, Y Wang, E Nicolas, ...
Cell reports 24 (13), 3513-3527. e7, 2018
Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification
MG Cornejo, V Mabialah, SM Sykes, T Khandan, C Lo Celso, CK Lopez, ...
Blood, The Journal of the American Society of Hematology 118 (5), 1264-1273, 2011
mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition
JJ Limon, L So, S Jellbauer, H Chiu, J Corado, SM Sykes, M Raffatellu, ...
Proceedings of the National Academy of Sciences 111 (47), E5076-E5085, 2014
Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells
M Nieborowska-Skorska, K Sullivan, Y Dasgupta, ...
The Journal of clinical investigation 127 (6), 2392-2406, 2017
Tyrosine kinase inhibitor–induced defects in DNA repair sensitize FLT3 (ITD)-positive leukemia cells to PARP1 inhibitors
S Maifrede, M Nieborowska-Skorska, K Sullivan-Reed, Y Dasgupta, ...
Blood, The Journal of the American Society of Hematology 132 (1), 67-77, 2018
RET-mediated autophagy suppression as targetable co-dependence in acute myeloid leukemia
S Rudat, A Pfaus, YY Cheng, J Holtmann, JM Ellegast, C Buehler, ...
Leukemia 32 (10), 2189-2202, 2018
JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia
C Zhou, E Martinez, D Di Marcantonio, N Solanki-Patel, T Aghayev, S Peri, ...
Leukemia 31 (5), 1196-1205, 2017
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